scholarly journals Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: The possible role of nuclear factor kappaB signaling pathway

2012 ◽  
Vol 131 (7) ◽  
pp. 1517-1527 ◽  
Author(s):  
Hui Yang ◽  
Xudong Jia ◽  
Xiaoxin Chen ◽  
Chung S. Yang ◽  
Ning Li
Keyword(s):  
Vitamin E ◽  
Signaling Pathway ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Esophageal Carcinogenesis

Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

2021 ◽  
Vol 509 ◽  
pp. 63-80 ◽  
Author(s):  
Sepideh Mirzaei ◽  
Ali Zarrabi ◽  
Farid Hashemi ◽  
Amirhossein Zabolian ◽  
Hossein Saleki ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Non Coding Rnas

The Role of Nuclear Factor-kappaB and Melanogenesis in Tumor Necrosis Factor-Alpha-Induced Apoptosis of Normal Human Melanocytes

2002 ◽  
Vol 15 (5) ◽  
pp. 321-329 ◽  
Author(s):  
Jing Shang ◽  
Jürgen Eberle ◽  
Christoph C. Geilen ◽  
Amir M. Hossini ◽  
Lothar F. Fecker ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Necrosis Factor Alpha ◽  
Human Melanocytes ◽  
Normal Human ◽  
Factor Alpha ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

2020 ◽  
Vol 18 (10) ◽  
pp. 918-935 ◽  
Author(s):  
Shareen Singh ◽  
Thakur Gurjeet Singh
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathway ◽  
Nuclear Factor Kappa B ◽  
Autoimmune Disorder ◽  
Nuclear Factor ◽  
Human Beings ◽  
Inhibitor Molecule ◽  
Nuclear Factor Kappa ◽  
Iκb Kinase

A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as a therapeutic approach. Activation of IκB kinase/NF-κB signaling pathway leads to the development of various pathological conditions in human beings, such as neurodegenerative, inflammatory disorders, autoimmune diseases, and cancer. Therefore, the transcriptional activity of IκB kinase/NF- κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes, including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing various diseases. Regulation of NF- κB signaling pathway may be a safe and effective treatment strategy for various disorders.

Activation of nuclear factor-kappaB signaling pathway by interleukin-1 after hypoxia/ischemia in neonatal rat hippocampus and cortex

2005 ◽  
Vol 93 (1) ◽  
pp. 26-37 ◽  
Author(s):  
Xiaoming Hu ◽  
Olivera Nesic-Taylor ◽  
Jingxin Qiu ◽  
Harriett C. Rea ◽  
Roderick Fabian ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Interleukin 1 ◽  
Rat Hippocampus ◽  
Neonatal Rat ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Hypoxia Ischemia

scholarly journals Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis

Oncogene ◽  
2003 ◽  
Vol 23 (14) ◽  
pp. 2507-2522 ◽  
Author(s):  
Sanjay Gupta ◽  
Kedar Hastak ◽  
Farrukh Afaq ◽  
Nihal Ahmad ◽  
Hasan Mukhtar
Keyword(s):  
Essential Role ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Induction Of Apoptosis

The role of the growth arrest-specific homeobox gene gax in inhibiting angiogenesis and nuclear factor-kappab signaling

2006 ◽  
Vol 130 (2) ◽  
pp. 162-163
Author(s):  
S. Patel ◽  
Y. Chen ◽  
H. Sohail ◽  
A.D. Leal ◽  
D.H. Gorski
Keyword(s):  
Growth Arrest ◽  
Homeobox Gene ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor

scholarly journals The nuclear factor-kappaB (NF-kappaB): from a versatile transcription factor to a ubiquitous therapeutic target.

2006 ◽  
Vol 53 (4) ◽  
pp. 651-662 ◽  
Author(s):  
Laura L Yates ◽  
Dariusz C Górecki
Keyword(s):  
Nuclear Factor Kappab ◽  
Specific Response ◽  
Nuclear Factor ◽  
Therapeutic Approaches ◽  
Altered Regulation ◽  
Nf Kappab ◽  
Novel Therapeutic Strategies ◽  
And Function

The nuclear factor-kappaB (NF-kappaB) transcription factors regulate a plethora of cellular pathways and processes including the immune response, inflammation, proliferation, apoptosis and calcium homeostasis. In addition to the complexity of its physiological roles, the composition and function of this family of proteins is very complicated. While the basic understanding of NF-kappaB signalling is extensive, relatively little is know of the in vivo dynamics of this pathway or what controls the balance between various outcomes. Although we know a large number of NF-kappaB-responsive genes, the contribution of these genes to a specific response is not always clear. Finally, the involvement of NF-kappaB in pathological processes is only now beginning to be unravelled. In addition to cancer and immunodeficiency disorders, altered regulation of NF-kappaB has been associated with several inherited diseases. These findings indicate that modulation of the NF-kappaB pathways may be beneficial. However, our limited knowledge of NF-kappaB signalling hinders therapeutic approaches: in many situations it is not clear whether the enhancement or inhibition of NF-kappaB activity would be beneficial or which pathways to interfere with and what the required level of activation is. Further studies of the role of NF-kappaB are needed as these may result in novel therapeutic strategies for a wide variety of diseases.

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