scholarly journals Visinin-like protein-1 overexpression is an indicator of lymph node metastasis and poor prognosis in colorectal cancer patients

2011 ◽  
Vol 131 (6) ◽  
pp. 1307-1317 ◽  
Author(s):  
Tomonori Akagi ◽  
Naoki Hijiya ◽  
Masafumi Inomata ◽  
Norio Shiraishi ◽  
Masatsugu Moriyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Poor Prognosis ◽  
Node Metastasis ◽  
Colorectal Cancer Patients

A Novel Mirna Signature for the Detection of Lymph Node Metastasis in Submucosal Colorectal Cancer Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S1019-S1020
Author(s):  
Tsuyoshi Ozawa ◽  
Feng Gao ◽  
Hiroaki Nozawa ◽  
Keisuke Hata ◽  
Hiroshi Nagata ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Mirna Signature ◽  
Node Metastasis ◽  
Novel Mirna ◽  
Colorectal Cancer Patients ◽  
Submucosal Colorectal Cancer

scholarly journals Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Keng-Liang Wu ◽  
Hong-Hwa Chen ◽  
Chen-Tzi Pen ◽  
Wen-Ling Yeh ◽  
Eng-Yen Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Enzyme Linked Immunosorbent Assay ◽  
Node Metastasis ◽  
Tumor Stages ◽  
Galectin 3 ◽  
Colorectal Cancer Patients

Background. The simultaneous correlation of serum galectin-1, galectin-3, and 90K/Mac-2BP levels with clinical stages of patients with colorectal cancer has not yet been clarified. We plan to measure the serum levels of galectin-1, galectin-3, and 90K/Mac-2BP of patients at different stages of colorectal cancer and analyze the correlation of these galectins with stages of colorectal cancers.Methods. 198 colorectal cancer patients (62 ± 13 (range 31–85) years old, 43.6% female) were recruited for this study. Subjects’ blood samples were checked for serum galectin-1, galectin-3, 90K/Mac-2BP, and carcinoembryonic antigen by sandwich enzyme-linked immunosorbent assay. We determined the correlation between plasma concentrations with clinical tumor stages.Results. Colorectal cancer patients with larger cancer sizes (stages T3, T4 rather than T1, T2) have higher serum 90K/Mac-2BP (P= 0.014) and patients with lymph node metastasis have higher serum galectin-1 (P= 0.002) but there was not a significant correlation between galectin-3 and tumor staging of colon cancer. In colorectal cancer patients even with normal carcinoembryonic antigen, serum galectin-1 could predict more lymph node metastasis.Conclusions. We found 90K/Mac-2BP correlated with the size of colorectal cancer. Galectin-1 but not galectin-3 was associated with lymph node metastasis. Galectin-1 could predict more lymph node metastasis in colorectal cancer patients with normal serum carcinoembryonic antigen.

Genetic variations are associated with lymph node metastasis in colorectal cancer patients

2014 ◽  
Vol 110 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Yuan-Tzu Lan ◽  
Shung-Haur Yang ◽  
Jen-Kou Lin ◽  
Chun-Chi Lin ◽  
Huann-Sheng Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Genetic Variations ◽  
Node Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Plasma miR-183-5p in colorectal cancer patients as potential predictive lymph node metastasis marker

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Reza Nekouian ◽  
Fatemeh Sanjabi ◽  
Abolfazl Akbari ◽  
Rezvan Mirzaei ◽  
Azam Fattahi
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Colorectal Cancer Patients

scholarly journals Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

2015 ◽  
Vol 9 (5) ◽  
pp. 2003-2006
Author(s):  
WEIJIA FANG ◽  
CAIYUN FU ◽  
XIAOGANG CHEN ◽  
XIAOZHOU MOU ◽  
FANLONG LIU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Colorectal Cancer Patients ◽  
Receptor Polymorphism

scholarly journals Analysis of risk factors and prognosis of 253 lymph node metastasis in colorectal cancer patients

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shidong Hu ◽  
Songyan Li ◽  
Da Teng ◽  
Yang Yan ◽  
Haiguan Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Staining Intensity ◽  
Node Negative ◽  
Node Metastasis ◽  
Lymph Node Positive ◽  
Colorectal Cancer Patients

Abstract Background This study aimed to explore potential risk factors for 253 lymph node metastasis, and to identify the prognostic impact of 253 lymph node metastasis in colorectal cancer patients. Methods A retrospective study was conducted of 391 colorectal cancer patients who underwent surgical treatments that included 253 lymph node dissection. Clinicopathological features, molecular indexes and 1-year overall survival rates were analyzed. Results Univariate analyses revealed the following risk factors for 253 lymph node metastasis: high preoperative levels of CEA, large tumour max diameters, and numbers of harvested lymph nodes, presence of vessel carcinoma emboli, low level of MSH6 and MLH1 immunohistochemical staining intensity. Multivariate analysis showed that elevated MLH1 immunohistochemical staining intensity was an independent protective factor for 253 lymph node metastasis (OR: 0.969, 95% CI 0.945, 0.994, P = 0.015). A significant difference was found in 1-year overall survival rate between 253 lymph node-positive and lymph node-negative colorectal cancer patients (88.9% vs.75.0%, P < 0.001). Conclusions 253 lymph node-positive colorectal cancer patients had a worse prognosis than the 253 lymph node-negative patients. 253 lymph node dissection may improve the prognosis of colorectal cancer patients with high risk factors for 253 lymph node metastasis.

scholarly journals Prognosis analysis of patients with resectable T4 colorectal cancer

2020 ◽  
Author(s):  
Wei Chen ◽  
Jun-Wen Ye ◽  
Xiao-ping Tan ◽  
Yan Zhang ◽  
Jing-Lin Liang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Disease Free Survival ◽  
Independent Factor ◽  
Node Metastasis ◽  
Colorectal Cancer Patients

Abstract Objective: To observe the factors related to survival and prognosis of patients with resectable stage T4 colorectal cancer. Methods : 148 patients with resectable stage T4 colorectal cancer who underwent surgery in the first Affiliated Hospital of Sun Yat-sen University between August, 1994 and December, 2005 were retrospectively analyzed. Univariate and multivariate analyses of associations between clinicopathological variables and survival were analyzed using the Cox regression model. Results: At the end of December of 2010 or death, the 5-year and 10 years OS rates were 49.0% and 32.2% respectively, the median OS was 25 months. The disease free survival rates (DFS) at 5 and 10 years were 44.2% and 30.3% respectively. In univariate analysis, patients with postoperative pathology lymph node metastasis was associated with the prognosis of patients with OS (all P< 0.01), postoperative adjuvant therapy failed to improve OS and DFS (P>0.05). Postoperative pathology lymph node metastasis was associated with DFS too (all P< 0.01). In multivariate analysis, postoperative pathology lymph node metastasis was independent factor affected OS and DFS in colorectal cancer patients. Conclusion: Postoperative prognosis of T4 colorectal cancer patients is poor, postoperative pathology lymph node positive was an independent factor affect OS and DFS.

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