scholarly journals Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers

2011 ◽  
Vol 130 (9) ◽  
pp. 2176-2184 ◽  
Author(s):  
Vivek R. Yadav ◽  
Sahdeo Prasad ◽  
Bokyung Sung ◽  
Juri G. Gelovani ◽  
Sushovan Guha ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Boswellic Acid ◽  
Human Colorectal Cancer ◽  
Orthotopic Mouse Model ◽  
Angiogenic Biomarkers

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX‐2, MMP‐9, VEGF and CXCR4 expression in an orthotopic mouse model

2009 ◽  
Vol 125 (9) ◽  
pp. 2187-2197 ◽  
Author(s):  
Ajaikumar B. Kunnumakkara ◽  
Parmeswaran Diagaradjane ◽  
Preetha Anand ◽  
Harikumar B. Kuzhuvelil ◽  
Amit Deorukhkar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Cyclin D1 ◽  
Cxcr4 Expression ◽  
Human Colorectal Cancer ◽  
Orthotopic Mouse Model ◽  
Cox 2

scholarly journals Establishment of an Endoscopy-Guided Minimally Invasive Orthotopic Mouse Model of Colorectal Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3007
Author(s):  
Chen Chen ◽  
Jens Neumann ◽  
Florian Kühn ◽  
Serene M. L. Lee ◽  
Moritz Drefs ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Minimally Invasive ◽  
Tumor Growth ◽  
Hepatic Metastases ◽  
Specific Cell ◽  
Local Tumor ◽  
Orthotopic Mouse Model ◽  
Endoscopic Score ◽  
Local Tumor Growth

Open orthotopic mouse models of colorectal cancer have disadvantages such as the requirement for advanced surgical skills or the trauma caused by laparotomy. To overcome these drawbacks, this study aimed to evaluate the establishment of a minimally invasive model using murine colonoscopy. CT26 and MC38 CRC cells of different concentrations were injected into BALB/C and C57BL/6J mice, respectively. Follow-up endoscopies were performed to assign an endoscopic score to tumor growth. Gross autopsy, histologic and immuno-histochemical evaluation, and immune scoring were performed. To describe the learning curve of the procedures, a performance score was given. Local tumor growth with colorectal wall infiltration, luminal ulceration, the presence of tumor-infiltrating lymphocytes, lympho-vascular invasion, and early spontaneous lymph node, peritoneal, and hepatic metastases were observed. The tumors showed cytoplasmic immuno-staining for CK20. Compared to the MC38/C57BL/6J model, tumorigenicity and immunogenicity of the CT26/BALB/C model were higher. Tumor volume correlated with the endoscopic score. This endoscopy-guided orthotopic mouse model is easy to learn and quick to establish. It features early metastasis and enables the study of interactions with the immune system. When specific cell concentrations and cell lines are applied, controlled local tumor growth and metastasis can be achieved within short observation periods.

scholarly journals The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (43) ◽  
pp. 27104-27116 ◽  
Author(s):  
Jonathan P. Evans ◽  
Boleslaw K. Winiarski ◽  
Paul A. Sutton ◽  
Robert P. Jones ◽  
Lorenzo Ressel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Orthotopic Mouse Model ◽  
Antitumour Agent
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