Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro

2011 ◽  
Vol 130 (7) ◽  
pp. 1577-1589 ◽  
Author(s):  
P. Correale ◽  
C. Botta ◽  
M.G. Cusi ◽  
M.T. Del Vecchio ◽  
M.M. De Santi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Dendritic Cell ◽  
Cancer Cells ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
Colon Cancer Cells ◽  
Cancer Antigen

Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A∗0201 restricted epitopes

2007 ◽  
Vol 256 (2) ◽  
pp. 178-185 ◽  
Author(s):  
Paul Ha-Sang Pang ◽  
Kin-Tak Chan ◽  
Luigi Ying-Wai Tse ◽  
Ray Chun-Fai Chan ◽  
Ying-Kit Cheung ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Cells ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell

scholarly journals Tumor-Released Survivin Induces a Type-2 T Cell Response and Decreases Cytotoxic T Cell Function, in Vitro

2012 ◽  
Vol 6 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Jessica M. S. Jutzy ◽  
Salma Khan ◽  
Malyn May Asuncion-Valenzuela ◽  
Terry-Ann M. Milford ◽  
Kimberly J. Payne ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Cell Function ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
T Cell Function

scholarly journals Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.

1990 ◽  
Vol 171 (5) ◽  
pp. 1815-1820 ◽  
Author(s):  
P Aichele ◽  
H Hengartner ◽  
R M Zinkernagel ◽  
M Schulz
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Lymphocytic Choriomeningitis ◽  
Effector T Cells ◽  
T Cell Response ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Effector T Cell

Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.

Whole-tumor-antigen-pulsed dendritic cells elicit cytotoxic T-cell response against pediatric nasopharyngeal carcinoma in vitro

2008 ◽  
Vol 26 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Dou Yufeng ◽  
Zhang Guocheng ◽  
Xu Dongliang ◽  
Fu Rong ◽  
Cao Yuhong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Nasopharyngeal Carcinoma ◽  
Tumor Antigen ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell

scholarly journals Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.

1978 ◽  
Vol 147 (4) ◽  
pp. 1236-1252 ◽  
Author(s):  
T J Braciale ◽  
K L Yap
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
T Cell ◽  
Cell Response ◽  
Infectious Virus ◽  
Cytotoxic T Cells ◽  
T Cell Response ◽  
Cytotoxic T Cell

This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T-cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus-specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.

Oligopeptide Induction of a Secondary Cytotoxic T-cell Response to Epstein-Barr Virus In Vitro

1991 ◽  
Vol 33 (4) ◽  
pp. 411-420 ◽  
Author(s):  
C. SCHMIDT ◽  
S. R. BURROWS ◽  
D. J. MOSS ◽  
T. B. SCULLEY ◽  
I. S. MISKO
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Epstein Barr Virus ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Gut mucosal immunization with reovirus serotype 1/L stimulates virus-specific cytotoxic T cell precursors as well as IgA memory cells in Peyer's patches.

1987 ◽  
Vol 165 (3) ◽  
pp. 830-847 ◽  
Author(s):  
S D London ◽  
D H Rubin ◽  
J J Cebra
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Peyer's Patches ◽  
Cytotoxic T Cell ◽  
Peyer’S Patches ◽  
Memory Cells ◽  
Mucosal Tissues

In this report we have shown that reovirus 1/L is an effective mucosal immunogen capable of generating a cytotoxic T cell (CTL) and associated helper T cell response to the nominal antigens associated with reovirus 1/L. The effectors that mediate reovirus-specific cytotoxicity are Thy-1+, Lyt-2+, and major histocompatibility complex (MHC)-restricted in their recognition of reovirus antigens, and can therefore be classified as CTLs. Frequency analysis of precursor CTLs occurring in Peyer's patches (PP) and peripheral lymph nodes (PLN) 6 d and 6 mo after intraduodenal stimulation have demonstrated that a persistent gradient of precursors is established, with higher frequencies present in PP. The generation of a CTL response in PP may be important in preferentially repopulating mucosal tissues with effector CTLs that could result in the local containment of infections in the gut. We also found that reovirus 1/L generates a virus-specific B cell response that is dominated by IgA memory cells after intraduodenal immunization. We hypothesize that the efficacy of reovirus 1/L at stimulating T and B cells in the gut mucosa is related to its ability to selectively enter PP via microfold (M) cells after enteric application. In this study we have also demonstrated that PP cells, upon in vitro culture and unrelated to prior reovirus priming, can generate natural killer-like (NK) cytotoxic activity. This may be an in vitro correlate of the in vivo generation of effectors that may populate mucosal tissues (i.e., the intestinal epithelium) with NK-like effector cells.

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