scholarly journals Indocyanine green enhanced near-infrared laser treatment of murine mammary carcinoma

2011 ◽  
Vol 130 (5) ◽  
pp. 1208-1215 ◽  
Author(s):  
Gal Shafirstein ◽  
Wolfgang Bäumler ◽  
Leah J. Hennings ◽  
Eric R. Siegel ◽  
Ran Friedman ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Laser Treatment ◽  
Mammary Carcinoma ◽  
Near Infrared ◽  
Infrared Laser ◽  
Murine Mammary Carcinoma

Indocyanine green enhanced near infrared laser treatment of SCK tumors in a mouse model pilot study

2011 ◽  
Author(s):  
Gal Shafirstein ◽  
Wolfgang Bäumler ◽  
Ran Friedman ◽  
Leah Hennings ◽  
Jessica Webber ◽  
...  
Keyword(s):  
Pilot Study ◽  
Mouse Model ◽  
Indocyanine Green ◽  
Laser Treatment ◽  
Near Infrared ◽  
Infrared Laser

Use of Indocyanine Green Near-Infrared Laser Confocal Endomicroscopy In Vivo: Potential to Intraoperatively Detect the Boundary of Infiltrative Tumor

Neurosurgery ◽  
2010 ◽  
Vol 67 (2) ◽  
pp. 562-562 ◽  
Author(s):  
Nikolay L. Martirosyan ◽  
Daniel Dutra Cavalcanti ◽  
Jennifer M. Eschbacher ◽  
Peter Delaney ◽  
Mohammed G. Abdelwahab ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Laser ◽  
Confocal Endomicroscopy ◽  
Infiltrative Tumor

Effects of a single near-infrared laser treatment on cutaneous wound healing: Biometrical and histological study in rats

2007 ◽  
Vol 87 (3) ◽  
pp. 145-153 ◽  
Author(s):  
Sandra B. Rezende ◽  
Martha S. Ribeiro ◽  
Silvia C. Núñez ◽  
Valdir G. Garcia ◽  
Edison P. Maldonado
Keyword(s):  
Wound Healing ◽  
Laser Treatment ◽  
Near Infrared ◽  
Histological Study ◽  
Infrared Laser ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Broad Spectrum Antibacterial Photodynamic and Photothermal Therapy Achieved with Indocyanine Green Loaded SPIONs under Near Infrared Irradiation

2020 ◽  
Author(s):  
Havva Yagci acar ◽  
Kubra Bilici ◽  
Nazlı Atac ◽  
Abdullah Muti ◽  
Isınsu Baylam ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Laser Treatment ◽  
Photothermal Therapy ◽  
Low Dose ◽  
Near Infrared ◽  
Planktonic Cells ◽  
Gram Negative ◽  
Log Reduction

Abstract Background: Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms. Combination of nanoparticles and organic photosensitizers offer a great opportunity to combine PDT and PTT for effective eradication of both planktonic bacteria and their biofilms. In this work, photo-induced antibacterial activity of indocyanine green (ICG), 3-aminopropylsilane coated superparamagnetic iron oxide nanoparticles (APTMS@SPION) and ICG loaded APTMS@SPION were evaluated on planktonic cells and biofilms of gram-negative ( E.coli , K.pneumoniae , P.aeruginosa) and gram-positive ( S.epidermis) bacteria . Results: A relatively low dose of ICG (25 mg/mL) and SPIONs (0.425 mg/mL nanoparticle) in combination with a single, short (10 min) laser irradiation at 808 nm with 1150 mW of power were used in this study. No dark toxicity of the agents or antibacterial effect of the laser irradiation were observed. The charge of the particles did not provide a significant difference in their penetration to gram-negative versus gram-positive bacterial strains or their biofilms. APTMS@SPION/laser treatment completely eliminated P.aeruginosa and provided 7-log reduction in the colony forming unit (CFU) of E.Coli, but was not effective on the other two bacteria . This is the first example for antibacterial phototoxicity of this nanoparticle. ICG/laser and ICG-APTMS@SPION/laser treatments provided complete killing of all planktonic cells . Successful eradication of all biofilms were achieved with ICG/laser (3.2-3.7 log reduction in CFU) or ICG-APTMS@SPION/laser treatment (3.3-4.4 log reduction in CFU). However, an exceptionally high, 6.5-log reduction as well as a dramatic difference between ICG versus ICG/APTMS@SPION treatment was observed in K.pneumoniae biofilms with ICG-APTMS@SPION/laser treatment. Investigation of the ROS production and increase in the local temperature of the biofilms that were subjected to phototherapy suggested a combination of aPTT and aPDT mechanisms for phototoxicity, exhibiting a synergistic effect when ICG-APTMS@SPION/laser was used. Conclusions: This approach opens an exciting and novel avenue in the fight against drug resistant infections by successfully utilizing the antimicrobial and antibiofilm activity of low dose FDA approved optically traceable ICG and a relatively low cost clinically acceptable iron oxide nanoparticle to enable effective aPDT/aPTT combination, induced via short-duration laser irradiation at a near-infrared wavelength.

Antibacterial photodynamic treatment of periodontopathogenic bacteria with indocyanine green and near-infrared laser light enhanced by TroloxTM

2015 ◽  
Vol 47 (4) ◽  
pp. 350-360 ◽  
Author(s):  
Stefan Kranz ◽  
Marie Huebsch ◽  
Andre Guellmar ◽  
Andrea Voelpel ◽  
Silke Tonndorf-Martini ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Laser Light ◽  
Infrared Laser ◽  
Photodynamic Treatment ◽  
Periodontopathogenic Bacteria

Photothermal Ablation of Human Lung Cancer by Low-power Near-Infrared Laser and Topical Injection of Indocyanine Green

2015 ◽  
Vol 22 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Kentaro Hirohashi ◽  
Takashi Anayama ◽  
Hironobu Wada ◽  
Takahiro Nakajima ◽  
Tatsuya Kato ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Indocyanine Green ◽  
Low Power ◽  
Near Infrared ◽  
Human Lung ◽  
Infrared Laser ◽  
Human Lung Cancer ◽  
Photothermal Ablation
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