scholarly journals Rapamycin enhances the activity of oncolytic herpes simplex virus against tumor cells that are resistant to virus replication

2011 ◽  
Vol 129 (6) ◽  
pp. 1503-1510 ◽  
Author(s):  
Xinping Fu ◽  
Lihua Tao ◽  
Armando Rivera ◽  
Xiaoliu Zhang
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Tumor Cells ◽  
Virus Replication ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus

scholarly journals Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 118
Author(s):  
Bangxing Hong ◽  
Upasana Sahu ◽  
Matthew P. Mullarkey ◽  
Balveen Kaur
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Solid Tumors ◽  
Tumor Cells ◽  
Stromal Cells ◽  
Tumor Antigens ◽  
Oncolytic Herpes Simplex Virus ◽  
Promising Treatment ◽  
Simplex Virus ◽  
Insight Into

Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit efficacy. The process of infection, replication and transmission of oHSV in solid tumors is key to obtaining a good lytic destruction of infected cancer cells to kill tumor cells and release tumor antigens that can prime anti-tumor efficacy. Intracellular tumor cell signaling and tumor stromal cells present multiple barriers that resist oHSV activity. Here, we provide a review focused on oncolytic HSV and the essential viral genes that allow for virus replication and spread in order to gain insight into how manipulation of these pathways can be exploited to potentiate oHSV infection and replication among tumor cells.

Corrigendum to “Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts” [Anti. Res. 179 (2020) 104818]

2021 ◽  
Vol 188 ◽  
pp. 105022
Author(s):  
Diana M. Alvarez ◽  
Luisa F. Duarte ◽  
Nicolas Corrales ◽  
Patricio C. Smith ◽  
Pablo A. González
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Cetylpyridinium Chloride ◽  
Gingival Fibroblasts ◽  
Simplex Virus

scholarly journals Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway

2009 ◽  
Vol 83 (23) ◽  
pp. 12399-12406 ◽  
Author(s):  
Vineet D. Menachery ◽  
David A. Leib
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Early Recognition ◽  
Critical Role ◽  
Type I ◽  
Type I Ifn ◽  
Regulatory Factor ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACT The type I interferon (IFN) cascade is critical in controlling viral replication and pathogenesis. Recognition pathways triggered by viral infection rapidly induce the type I IFN cascade, often in an IFN regulatory factor 3 (IRF-3)-dependent fashion. This dependence predicts that loss of IRF-3 would render early recognition pathways inoperative and thereby impact virus replication, but this has not been observed previously with herpes simplex virus type 1 (HSV-1) in vitro. In this study, HSV-1-infected IRF-3−/− bone marrow-derived dendritic cells (BMDCs) and macrophages supported increased HSV replication compared to control cells. In addition, IRF-3-deficient BMDCs exhibited delayed type I IFN synthesis compared to control cells. However, while IFN pretreatment of IRF-3−/− BMDCs resulted in reduced virus titers, a far greater reduction was seen after IFN treatment of wild-type cells. This suggests that even in the presence of exogenously supplied IFN, IRF-3−/− BMDCs are inherently defective in the control of HSV-1 replication. Together, these results demonstrate a critical role for IRF-3-mediated pathways in controlling HSV-1 replication in cells of the murine immune system.

scholarly journals CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

2011 ◽  
Vol 85 (19) ◽  
pp. 9945-9955 ◽  
Author(s):  
S. J. Allen ◽  
K. R. Mott ◽  
A. A. Chentoufi ◽  
L. BenMohamed ◽  
S. L. Wechsler ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus
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