scholarly journals 5′-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat

2010 ◽  
Vol 128 (9) ◽  
pp. 2230-2239 ◽  
Author(s):  
Taichang Jang ◽  
Joy M. Calaoagan ◽  
Eunice Kwon ◽  
Steven Samuelsson ◽  
Lawrence Recht ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Protein Kinase ◽  
Kinase Activity ◽  
Tumor Development ◽  
Primary Brain Tumor ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase

14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats

Alcohol ◽  
2014 ◽  
Vol 48 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Samir Mandal ◽  
Sibabrata Mukhopadhyay ◽  
Sukdeb Bandhopadhyay ◽  
Gargi Sen ◽  
Tuli Biswas
Keyword(s):  
Protein Kinase ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase ◽  
Stimulation Of

scholarly journals Increased AMP:ATP Ratio and AMP-activated Protein Kinase Activity during Cellular Senescence Linked to Reduced HuR Function

2003 ◽  
Vol 278 (29) ◽  
pp. 27016-27023 ◽  
Author(s):  
Wengong Wang ◽  
Xiaoling Yang ◽  
Isabel López de Silanes ◽  
David Carling ◽  
Myriam Gorospe
Keyword(s):  
Protein Kinase ◽  
Cellular Senescence ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase

Measurement of AMP-Activated Protein Kinase Activity and Expression in Response to Ghrelin

2012 ◽  
pp. 271-287 ◽  
Author(s):  
Chung Thong Lim ◽  
Francesca Lolli ◽  
Julia D. Thomas ◽  
Blerina Kola ◽  
Márta Korbonits
Keyword(s):  
Protein Kinase ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase

scholarly journals Regulation of 5′-AMP-activated Protein Kinase Activity by the Noncatalytic β and γ Subunits

1996 ◽  
Vol 271 (30) ◽  
pp. 17798-17803 ◽  
Author(s):  
Jason R. B. Dyck ◽  
Guang Gao ◽  
Jane Widmer ◽  
David Stapleton ◽  
C. Shamala Fernandez ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase

scholarly journals Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

2005 ◽  
Vol 329 (2) ◽  
pp. 719-725 ◽  
Author(s):  
Ulrika Andersson ◽  
Jonas T. Treebak ◽  
Jakob N. Nielsen ◽  
Kirsty L. Smith ◽  
Caroline R. Abbott ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Amp Activated Protein Kinase

scholarly journals Pak1 Protein Kinase Regulates Activation and Nuclear Localization of Snf1-Gal83 Protein Kinase

2004 ◽  
Vol 24 (18) ◽  
pp. 8255-8263 ◽  
Author(s):  
Kristina Hedbacker ◽  
Seung-Pyo Hong ◽  
Marian Carlson
Keyword(s):  
Protein Kinase ◽  
Nuclear Localization ◽  
Kinase Activity ◽  
Fluorescent Protein ◽  
Protein Kinase Activity ◽  
Activation Loop ◽  
Glucose Limitation ◽  
Subunit Isoforms ◽  
Green Fluorescent ◽  
Amp Activated Protein Kinase

ABSTRACT Three kinases, Pak1, Tos3, and Elm1, activate Snf1 protein kinase in Saccharomyces cerevisiae. This cascade is conserved in mammals, where LKB1 activates AMP-activated protein kinase. We address the specificity of the activating kinases for the three forms of Snf1 protein kinase containing the β-subunit isoforms Gal83, Sip1, and Sip2. Pak1 is the most important kinase for activating Snf1-Gal83 in response to glucose limitation, but Elm1 also has a significant role; moreover, both Pak1 and Elm1 affect Snf1-Sip2. These findings exclude the possibility of a one-to-one correspondence between the activating kinases and the Snf1 complexes. We further identify a second, unexpected role for Pak1 in regulating Snf1-Gal83: the catalytic activity of Pak1 is required for the nuclear enrichment of Snf1-Gal83 in response to carbon stress. The nuclear enrichment of Snf1 fused to green fluorescent protein (GFP) depends on both Gal83 and Pak1 and is abolished by a mutation of the activation loop threonine; in contrast, the nuclear enrichment of Gal83-GFP occurs in a snf1Δ mutant and depends on Pak1 only when Snf1 is present. Snf1-Gal83 is the only form of the kinase that localizes to the nucleus. These findings, that Pak1 both activates Snf1-Gal83 and controls its nuclear localization, implicate Pak1 in regulating nuclear Snf1 protein kinase activity.

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