scholarly journals High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis

2010 ◽  
Vol 127 (6) ◽  
pp. 1373-1383 ◽  
Author(s):  
Anguraj Sadanandam ◽  
Michelle L. Varney ◽  
Seema Singh ◽  
Abdelkader E. Ashour ◽  
Nicolas Moniaux ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Tumor Growth ◽  
Invasion And Metastasis ◽  
High Gene Expression ◽  
High Gene ◽  
Semaphorin 5A

scholarly journals Retained Heterodisomy Is Associated with High Gene Expression in Hyperhaploid Inflammatory Leiomyosarcoma

Neoplasia ◽  
2012 ◽  
Vol 14 (9) ◽  
pp. 807-IN5 ◽  
Author(s):  
Karolin H. Nord ◽  
Kajsa Paulsson ◽  
Srinivas Veerla ◽  
Johan Wejde ◽  
Otte Brosjö ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Gene Expression ◽  
High Gene

scholarly journals Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression

2014 ◽  
Vol 7 (1) ◽  
pp. 28 ◽  
Author(s):  
Rachel Edgar ◽  
Powell Patrick Tan ◽  
Elodie Portales-Casamar ◽  
Paul Pavlidis
Keyword(s):  
Gene Expression ◽  
Meta Analysis ◽  
Cpg Islands ◽  
High Gene Expression ◽  
High Gene

scholarly journals Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Clara S. M. Tang ◽  
Richard J. Epstein
Keyword(s):  
Gene Expression ◽  
Human Genome ◽  
Genetic Instability ◽  
Evolutionary Rate ◽  
Gc Content ◽  
Active Chromatin ◽  
Potential Explanation ◽  
High Gene Expression ◽  
High Gene ◽  
Variant Genes

We recently reported that the human genome is ‘‘splitting’’ into two gene subgroups characterised by polarised GC content (Tang et al, 2007), and that such evolutionary change may be accelerated by programmed genetic instability (Zhao et al, 2008). Here we extend this work by mapping the presence of two separate high-evolutionary-rate (Ka/Ks) hotspots in the human genome—one characterized by low GC content, high intron length, and low gene expression, and the other by high GC content, high exon number, and high gene expression. This finding suggests that at least two different mechanisms mediate adaptive genetic evolution in higher organisms: (1) intron lengthening and reduced repair in hypermethylated lowly-transcribed genes, and (2) duplication and/or insertion events affecting highly-transcribed genes, creating low-essentiality satellite daughter genes in nearby regions of active chromatin. Since the latter mechanism is expected to be far more efficient than the former in generating variant genes that increase fitnesss, these results also provide a potential explanation for the controversial value of sequence analysis in defining positively selected genes.

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