scholarly journals The Swedish Family-Cancer Database 2009: prospects for histology-specific and immigrant studies

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Kari Hemminki ◽  
Jianguang Ji ◽  
Andreas Brandt ◽  
Seyed Mohsen Mousavi ◽  
Jan Sundquist
2010 ◽  
Vol 17 (2) ◽  
pp. 329-334 ◽  
Author(s):  
Kari Hemminki ◽  
Seyed Mohsen Mousavi ◽  
Andreas Brandt ◽  
Jianguang Ji ◽  
Jan Sundquist

The changes of cancer incidence upon immigration have been used as an estimator of environmental influence on cancer risk. The previous immigrant studies have indicated that the origins of testicular cancer are at an early age in life, probably in the intrauterine period. We wanted to reexamine the critical periods on histology-specific testicular cancer in sons of immigrants to Sweden. We used the nationwide Swedish Family-Cancer Database to calculate standardized incidence ratios (SIRs) for testicular cancer in sons of parents immigrating to Sweden from low- and high-risk countries compared with the native Swedes. Among the large immigrant groups, the SIRs for sons of two Finnish and Asian parents were decreased if the sons were born outside Sweden. The sons of a Danish immigrant couple showed an increased risk of testicular cancer. The changes in SIR were most systematic for seminoma. The present patterns of testicular cancer risk among sons of immigrants point to the early environmental risk factors, which influence the risk probably after the intrauterine period. These factors appear to influence seminoma risk in a more enduring way than they influence non-seminoma.


2019 ◽  
Author(s):  
Johan Thermaenius ◽  
Anna Schandl ◽  
Kerstin Prignitz Sluys

1999 ◽  
Vol 20 (5) ◽  
pp. 698-717 ◽  
Author(s):  
ANN-ZOFIE E. DUVANDER

In Sweden, cohabitation is the norm before marriage and is in many ways equal to marriage. By investigating the transition from cohabitation to marriage, this study seeks to clarify how those who marry differ from those who do not. The study uses the Swedish Family Survey of 1992 together with register data of marriages and births for the following 2 years. Information on partner's attitudes and marriage plans is obtained from a self-administered questionnaire. The risk of marriage for women who were cohabiting at the time of interview is analyzed with event history analysis. The results show that life course stage, economic gains in marriage, and family socialization predict whether cohabiting women will turn their unions into marriages. In addition, attitudes toward leisure and parenthood influence marriage propensities. Marriage plans explain some, but not all, of those effects.


Mutagenesis ◽  
2019 ◽  
Vol 35 (3) ◽  
pp. 207-219
Author(s):  
Hongyao Yu ◽  
Kari Hemminki

Abstract We review here data on familial risk in colorectal cancer (CRC) generated from the Swedish Family-Cancer Database, the largest resource of its kind in the world. Although the concordant familial risk for CRC (i.e. CRC risk in families of CRC patients) has been reasonably well established, the studies on discordant familial risks (i.e. CRC risk in families with any other cancers) are rare. Because different cancers could be caused by shared genetic susceptibility or shared environment, data of associations of discordant cancers may provide useful information for identifying common risk factors. In analyses between any of 33 discordant cancers relative risks (RRs) for discordant cancers were estimated in families with increasing numbers of probands with CRC; in the reverse analyses, RRs for CRC were estimated in families with increasing numbers of probands with discordant cancers. In separate analyses, hereditary non-polyposis colorectal cancer (HNPCC) families were excluded from the study, based on HNPCC related double primary cancers, to assess the residual familial RRs. We further reviewed familial risks of colon and rectal cancers separately in search for distinct discordant associations. The reviewed data suggested that colon cancer was associated with a higher familial risk for CRC compared to rectal cancer. The previous data had reported associations of CRC with melanoma, thyroid and eye cancers. Nervous system cancer was only associated with colon cancer, and lung cancer only associated with rectal cancer. The reviewed data on discordant association may provide guidance to gene identification and may help genetic counseling.


2011 ◽  
Vol 105 (04) ◽  
pp. 733-734 ◽  
Author(s):  
Elsa Lanke ◽  
Torbjörn Säll ◽  
Stefan Lethagen ◽  
Christer Halldén ◽  
Anna Johansson

Amyloid ◽  
2005 ◽  
Vol 12 (3) ◽  
pp. 189-192 ◽  
Author(s):  
Gösta Holmgren ◽  
Urban Hellman ◽  
Jenni Jonasson ◽  
Hans-eric Lundgren ◽  
Per Westermark ◽  
...  
Keyword(s):  

2011 ◽  
Vol 21 (3) ◽  
pp. 225-237 ◽  
Author(s):  
Pernilla Tunberger ◽  
Wendy Sigle-Rushton

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