Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Masakazu Yashiro ◽  
Osamu Shinto ◽  
Kazunori Nakamura ◽  
Masashige Tendo ◽  
Tasuku Matsuoka ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Antitumor Effects ◽  
Scirrhous Gastric Carcinoma

scholarly journals A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma

Oncogene ◽  
2001 ◽  
Vol 20 (39) ◽  
pp. 5525-5532 ◽  
Author(s):  
Shinji Tanaka ◽  
Keishi Sugimachi ◽  
Hiroshi Saeki ◽  
Junko Kinoshita ◽  
Takefumi Ohga ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Novel Variant ◽  
Scirrhous Gastric Carcinoma ◽  
Type C ◽  
Von Willebrand

A tumor-associated antigen in the scirrhous gastric carcinoma cell line MK-01 defined by monoclonal antibody S202

1989 ◽  
Vol 19 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Takashi Yokota ◽  
Takashi Masuko ◽  
Toshiharu Yamaguchi ◽  
Kazuya Kitamura ◽  
Toshio Takahashi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Gastric Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Gastric Carcinoma Cell ◽  
Gastric Carcinoma Cell Line ◽  
Tumor Associated Antigen ◽  
Scirrhous Gastric Carcinoma

scholarly journals Myofibroblasts are associated with the progression of scirrhous gastric carcinoma

2010 ◽  
Vol 1 (4) ◽  
pp. 547-551 ◽  
Author(s):  
YUHIKO FUYUHIRO ◽  
MASAKAZU YASHIRO ◽  
SATORU NODA ◽  
SHINICHIRO KASHIWAGI ◽  
JUNKO MATSUOKA ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma

A novel K-samII/FGF-R2 autophosphorylation inhibitor is therapeutically useful for scirrhous gastric carcinoma with K-samII amplification

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14070-14070
Author(s):  
M. Yashiro ◽  
K. Nakamura ◽  
T. Sawada ◽  
H. Kawajiri ◽  
T. Shimizu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Gastric Carcinoma ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Growth Factor Receptor ◽  
Carcinoma Cells ◽  
Apoptosis Pathway ◽  
Scirrhous Gastric Cancer ◽  
Scirrhous Gastric Carcinoma

14070 Background: Scirrhous gastric carcinoma, a diffusely infiltrating also known as linitis plastica-type carcinoma, carries the highest mortality of all gastric cancers. Scirrhous carcinoma cells with amplification of the activated K-samII gene, which encodes fibroblast growth factor receptor type 2 (FGF-R2), have a growth advantage during tumor progression The poor prognosis carried by scirrhous gastric cancer is closely associated with amplification of the K-samII/FGF-R2, a tyrosine kinase growth factor receptor. Ki23057, a newly developed small molecule acting K-samII/FGF-R2 inhibitor, is a kinase inhibitor that competes with ATP for the binding site in the kinase, thus strongly blocking phosphorylation of FGF-R2. The aim of the current study is to clarify the possibility of molecular target therapy with Ki23057 for treating scirrhous gastric cancer. Methods: Five human gastric cancer cell lines were used. OCUM-2MD3 and OCUM-8 were derived from scirrhous carcinomas. MKN-7, MKN-45 and MKN-74 cells were derived from non-scirrhous carcinomas. In vitro effects of Ki23057 on cell growth were determined by calculating the number of cancer cells. The influences of Ki23057 on the MAP kinase and PI3 kinase signaling pathways and the apoptosis pathway in the gastric cancer cells were also examined. For in vivo experiments, the Ki23057 was administered orally to mouse models of peritoneal dissemination. Results: K-samII amplification was found in OCUM-2MD3 and OCUM-8 cells, but not in MKN-7, MKN-45, or MKN-74 cells. Ki23057 significantly inhibited the proliferation of scirrhous cancer cells, but not non- scirrhous gastric carcinoma cells. Ki23057 decreased phosphorylation of K-samII/FGF-R2, ERK and Akt, and increased apoptosis in scirrhous cancer lines. The oral Ki23057 administration significantly (p<0.001) prolonged survival of mice with peritoneal dissemination following injection of OCUM-2MD3 scirrhous cancer cells. Conclusions: A novel K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, appears therapeutically promising in scirrhous gastric carcinoma with K-samII amplification. No significant financial relationships to disclose.

RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility

2011 ◽  
Vol 28 (7) ◽  
pp. 627-636 ◽  
Author(s):  
Tasuku Matsuoka ◽  
Masakazu Yashiro ◽  
Yukihiro Kato ◽  
Osamu Shinto ◽  
Shinichiro Kashiwagi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma

Cytophotometric study of nuclear DNA content in scirrhous gastric carcinoma

Pathology ◽  
1995 ◽  
Vol 27 (1) ◽  
pp. 5-7
Author(s):  
Yosuke Adachi ◽  
Masaki Mori ◽  
Masaru Haraguchi ◽  
Keizo Sugimachi ◽  
Masazumi Tsuneyoshi
Keyword(s):  
Gastric Carcinoma ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Scirrhous Gastric Carcinoma ◽  
Cytophotometric Study

scholarly journals Role of orthotopic fibroblasts in the development of Scirrhous gastric carcinoma

1995 ◽  
Vol 108 (4) ◽  
pp. A555
Author(s):  
M. Yashiro ◽  
Y.S. Chung ◽  
S. Nishimura ◽  
T. Inoue ◽  
T. Kubo ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma
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