scholarly journals Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis

2009 ◽  
Vol 125 (11) ◽  
pp. 2556-2564 ◽  
Author(s):  
James M. Haughian ◽  
Elaine M. Reno ◽  
Alicia M. Thorne ◽  
Andrew P. Bradford
Keyword(s):  
Endometrial Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Endometrial Cancer Cell ◽  
Kinase C ◽  
Protein Kinase C Alpha

scholarly journals Activation of protein kinase C promotes human cancer cell growth through downregulation of p18INK4c

Oncogene ◽  
2004 ◽  
Vol 23 (31) ◽  
pp. 5409-5414 ◽  
Author(s):  
Youichirou Matsuzaki ◽  
Yuuki Takaoka ◽  
Toshiaki Hitomi ◽  
Hoyoku Nishino ◽  
Toshiyuki Sakai
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Cancer Cell Growth ◽  
Kinase C

scholarly journals Endometrial cancer cell survival and apoptosis is regulated by protein kinase C α and δ

2006 ◽  
Vol 13 (4) ◽  
pp. 1251-1267 ◽  
Author(s):  
James M Haughian ◽  
Twila A Jackson ◽  
David M Koterwas ◽  
Andrew P Bradford
Keyword(s):  
Cell Death ◽  
Endometrial Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Cell ◽  
Molecular Mechanisms ◽  
Endometrial Cancer Cell ◽  
Kinase C ◽  
Pkc Isoforms ◽  
Induced Apoptosis

Endometrial cancer is the most common invasive gynecologic malignancy but the molecular mechanisms underlying its onset and progression are poorly understood. Paradoxically, endometrial tumors exhibit increased apoptosis, correlating with disease progression and poor patient prognosis. Endometrial tumors also show altered activity and expression of protein kinase C (PKC) isoforms, implicated in the regulation of programmed cell death; however, PKC modulation of apoptosis in endometrial cancer cells has not been investigated. We detected nine out of ten PKC isoforms in Ishikawa endometrial cancer cell lines, and demonstrated expression of both PKCα and δ in human endometrial tumors. To determine the functional roles of PKCα and δ in apoptosis in endometrial cancer, Ishikawa cells were treated with selective PKC inhibitors or adenoviral constructs encoding wild-type or isoform-specific, dominant-negative mutants. Apoptosis was assessed by DNA fragmentation and caspase-mediated poly-(ADP-ribose)-polymerase cleavage. The inhibition of PKCδ suppressed etoposide-induced apoptosis, while overexpression of PKCδ enhanced it. In contrast, inhibition of PKCα elevated basal levels of apoptosis and potentiated etoposide-induced cell death. Etoposide treatment also selectively activated PKCδ, but resulted in both cytosolic translocation and decreased activity of PKCα. A fraction of PKCδ also underwent caspase-dependent cleavage, in response to etoposide. Our results suggest that changes in apoptosis and PKC expression in endometrial cancer are mechanistically linked, such that PKCδ is required for DNA damage-induced apoptosis, while PKCα mediates a survival response. Thus, PKCα and δ expression and signaling may be important in endometrial tumorigenesis and could serve as potential prognostic indicators and/or novel targets for therapeutic intervention.

scholarly journals Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation

Oncotarget ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 4829-4844 ◽  
Author(s):  
Tetsuyuki Takahashi ◽  
Hisanori Uehara ◽  
Hirohisa Ogawa ◽  
Hitomi Umemoto ◽  
Yoshimi Bando ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Kinase C

scholarly journals Restoration of microRNA‑29c in type I endometrioid cancer reduced endometrial cancer cell growth

2019 ◽  
Author(s):  
Michelle Van Sinderen ◽  
Meaghan Griffiths ◽  
Ellen Menkhorst ◽  
Keith Niven ◽  
Evdokia Dimitriadis
Keyword(s):  
Endometrial Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Type I ◽  
Cancer Cell Growth ◽  
Endometrial Cancer Cell

Inhibition of human endometrial cancer cell growth in vitro and in vivo by somatostatin analog RC-160

1999 ◽  
Vol 181 (3) ◽  
pp. 583-590 ◽  
Author(s):  
Misako Mishima ◽  
Tetsu Yano ◽  
Haruko Jimbo ◽  
Naomi Yano ◽  
Yutaka Morita ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Somatostatin Analog ◽  
Cancer Cell Growth ◽  
Endometrial Cancer Cell
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