scholarly journals Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I

2009 ◽  
Vol 124 (9) ◽  
pp. 2042-2049 ◽  
Author(s):  
Sung-Hyeok Hong ◽  
Joseph Briggs ◽  
Rachel Newman ◽  
Karen Hoffman ◽  
Arnulfo Mendoza ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumour Growth ◽  
Serum Insulin ◽  
Primary Tumour ◽  
Insulin Like Growth Factor ◽  
Metastatic Progression ◽  
Factor I ◽  
Murine Osteosarcoma ◽  
Primary Tumour Growth ◽  
Marked Suppression

scholarly journals 35 Postnatal Serum Insulin-Like Growth Factor I Deficiency Is Associated with Chronic Lung Disease of Prematurity

2004 ◽  
Vol 56 (3) ◽  
pp. 470-470
Author(s):  
R J Bolt ◽  
M M van Weissenbruch ◽  
H N Lafeber ◽  
H A Delemarre-van de Waal
Keyword(s):  
Growth Factor ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency

2012 ◽  
Vol 509 (2) ◽  
pp. 101-104 ◽  
Author(s):  
R. Poirier ◽  
A.M. Fernandez ◽  
I. Torres-Aleman ◽  
F. Metzger
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I

2006 ◽  
Vol 26 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Philip Hanlon ◽  
William Andrew Lorenz ◽  
Zhihong Shao ◽  
James M. Harper ◽  
Andrzej T. Galecki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Genome Scan ◽  
Chromosome 17 ◽  
Insulin Like Growth Factor ◽  
Mouse Population ◽  
Factor I ◽  
A Genome ◽  
Igf I ◽  
Growth Factor I

A previous analysis of serum insulin-like growth factor I (IGF-I) levels in a mouse population ( n = 961) derived from a cross of (BALB/cJ × C57BL/6J) F1 females and (C3H/HeJ × DBA/2J) F1 males documented quantitative trait loci (QTL) on chromosomes 1, 10, and 17. We employed a newly developed, random walk-based method to search for three- and four-way allelic combinations that might influence IGF-I levels through nonadditive (conditional or epistatic) interactions among 185 genotyped biallelic loci and with significance defined by experiment-wide permutation ( P < 0.05). We documented a three-locus combination in which an epistatic interaction between QTL on paternal-derived chromosomes 5 and 18 had an opposite effect on the phenotype based on the allele inherited at a third locus on maternal-derived chromosome 17. The search also revealed three four-locus combinations that influence IGF-I levels through nonadditive genetic interactions. In two cases, the four-allele combinations were associated with animals having high levels of IGF-I, and, in the third case, a four-allele combination was associated with animals having low IGF-I levels. The multiple-locus genome scan algorithm revealed new IGF-I QTL on chromosomes 2, 4, 5, 7, 8, and 12 that had not been detected in the single-locus genome search and showed that levels of this hormone can be regulated by complex, nonadditive interactions among multiple loci. The analysis method can detect multilocus interactions in a genome scan experiment and may provide new ways to explore the genetic architecture of complex physiological phenotypes.

scholarly journals Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

Neuron ◽  
2010 ◽  
Vol 67 (5) ◽  
pp. 834-846 ◽  
Author(s):  
Takeshi Nishijima ◽  
Joaquin Piriz ◽  
Sylvie Duflot ◽  
Ana M. Fernandez ◽  
Gema Gaitan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Blood Brain Barrier ◽  
Neuronal Activity ◽  
Serum Insulin ◽  
Brain Barrier ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Blood Brain ◽  
Growth Factor I

scholarly journals Serum Insulin-Like Growth Factor-I (IGF-I) in Normal Japanese Adults.

1995 ◽  
Vol 42 (6) ◽  
pp. 767-770 ◽  
Author(s):  
MICHIE KITANO ◽  
TAEKO SHIMIZU ◽  
YUKO YAMAZAKI ◽  
YOSHIE UMEZU ◽  
YUKIKO ARAKAWA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Japanese Adults ◽  
Igf I ◽  
Growth Factor I ◽  
Normal Japanese
Sign in / Sign up

Export Citation Format

Share Document