scholarly journals Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor

2008 ◽  
Vol 123 (7) ◽  
pp. 1491-1498 ◽  
Author(s):  
Masaru Oba ◽  
Koichi Miwa ◽  
Takashi Fujimura ◽  
Shinichi Harada ◽  
Shozo Sasaki ◽  
...  
Keyword(s):  
Duodenogastric Reflux ◽  
Glandular Stomach ◽  
Cox 2 ◽  
Stomach Carcinogenesis

scholarly journals Gastric proliferative lesions induced by duodenogastric reflux in rats

2006 ◽  
Vol 21 (4) ◽  
pp. 207-213 ◽  
Author(s):  
Rosângela Lucinda Rocha Monteiro ◽  
Nelson Adami Andreollo ◽  
Maria Aparecida Marchesan Rodrigues ◽  
Marina Raquel Araujo
Keyword(s):  
High Frequency ◽  
Posterior Wall ◽  
Duodenogastric Reflux ◽  
Glandular Stomach ◽  
Male Rats ◽  
Gastrojejunal Anastomosis ◽  
Adenomatous Hyperplasia ◽  
Group Iii ◽  
Group I ◽  
Group Ii

PURPOSE: To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats. METHODS: Seventy-five healthy and adult male rats were divided into three groups: group I - control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II - DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III - DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach. RESULTS: Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%). CONCLUSIONS: The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence.

scholarly journals Suppressive effects of chlorogenic acid on N-methyl-N-nitrosourea-induced glandular stomach carcinogenesis in male F344 rats.

1999 ◽  
Vol 24 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Masahito SHIMIZU ◽  
Naoki YOSHIMI ◽  
Yasuhiro YAMADA ◽  
Kengo MATSUNAGA ◽  
Kunihiro KAWABATA ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Glandular Stomach ◽  
Stomach Carcinogenesis ◽  
F344 Rats ◽  
Male F344 Rats

scholarly journals Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells

2016 ◽  
Vol 15 (4) ◽  
pp. NP26-NP34 ◽  
Author(s):  
Nariman K. Badr El-Din ◽  
Salma M. Abdel Fattah ◽  
Deyu Pan ◽  
Lucilene Tolentino ◽  
Mamdooh Ghoneum
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Glandular Stomach ◽  
Chemical Induction ◽  
Gastric Cancer Cells ◽  
Ki 67 ◽  
P53 Expression ◽  
Apoptotic Effect ◽  
Stomach Carcinogenesis ◽  
Chemopreventive Activity

In the current study, we investigated the chemopreventive activity of arabinoxylan rice bran, MGN-3/Biobran, against chemical induction of glandular stomach carcinogenesis in rats. Gastric cancer was induced by carcinogen methylnitronitrosoguanidine (MNNG), and rats received MNNG alone or MNNG plus Biobran (40 mg/kg body weight) for a total of 8 months. Averaged results from 2 separate readings showed that exposure to MNNG plus Biobran caused gastric dysplasia and cancer (adenocarcinoma) in 4.5/12 rats (9/24 readings, 37.5%), with 3.5/12 rats (7/24 readings, 29.2%) showing dysplasia and 1/12 rats (8.3%) developing adenocarcinoma. In contrast, in rats treated with MNNG alone, 8/10 (80%) developed dysplasia and adenocarcinoma, with 6/10 rats (60%) showing dysplasia and 2/10 rats (20%) developing adenocarcinoma. The effect of combining both agents was also associated with significant suppression of the expression of the tumor marker Ki-67 and remarkable induction in the apoptotic gastric cancer cells via mitochondrial-dependent pathway as indicated by the upregulation in p53 expression, Bax expression, downregulation in Bcl-2 expression, an increase in Bax/Bcl-2 ratio, and an activation of caspase-3. In addition, Biobran treatment induced cell-cycle arrest in the subG1 phase, where the hypodiploid cell population was markedly increased. Moreover, Biobran treatment protected rats against MNNG-induced significant decrease in lymphocyte levels. We conclude that Biobran provides protection against chemical induction of glandular stomach carcinogenesis in rats and may be useful for the treatment of human patients with gastric cancer.

scholarly journals Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/c Mice Initiated withN-Methyl-N-nitrosourea

1997 ◽  
Vol 88 (12) ◽  
pp. 1143-1148 ◽  
Author(s):  
Kiyoshi Kobayashi ◽  
Nobuyuki Shimizu ◽  
Tetsuya Tsukamoto ◽  
Ken-ichi Inada ◽  
Hayao Nakanishi ◽  
...  
Keyword(s):  
Glandular Stomach ◽  
Stomach Carcinogenesis ◽  
Dose Dependent

Effects of low dose catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N -methyl- N -nitrosourea

1999 ◽  
Vol 139 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Kiyoshi Kobayashi ◽  
Ken-ichi Inada ◽  
Chie Furihata ◽  
Tetsuya Tsukamoto ◽  
Yuzuru Ikehara ◽  
...  
Keyword(s):  
Low Dose ◽  
Glandular Stomach ◽  
Stomach Carcinogenesis

scholarly journals Concurrent Administration of Fish Meal and Sodium Nitrite Does not Promote Glandular Stomach Carcinogenesis in Rats after Treatment with N-methyl-N'-nitro-N-nitrosoguanidine.

1999 ◽  
Vol 12 (4) ◽  
pp. 171-176
Author(s):  
Fumio Furukawa ◽  
Akiyoshi Nishikawa ◽  
Makoto Miyauchi ◽  
Hideaki Nakamura ◽  
Hwa-Young Son ◽  
...  
Keyword(s):  
Sodium Nitrite ◽  
Fish Meal ◽  
Glandular Stomach ◽  
Concurrent Administration ◽  
Stomach Carcinogenesis

scholarly journals Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure

2013 ◽  
Vol 28 (6) ◽  
pp. 453-457 ◽  
Author(s):  
Paulo Antônio Rodrigues ◽  
Luiz Eduardo Naresse ◽  
Maria Aparecida Marchesan Rodrigues ◽  
Shoiti Kobayasi
Keyword(s):  
Duodenogastric Reflux ◽  
Gastric Tumors ◽  
Cox 2

Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride

1995 ◽  
Vol 33 (1) ◽  
pp. 21-26 ◽  
Author(s):  
A. Nishikawa ◽  
F. Furukawa ◽  
T. Imazawa ◽  
S. Ikezaki ◽  
T. Hasegawa ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Glandular Stomach ◽  
Stomach Carcinogenesis

scholarly journals Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens

1999 ◽  
Vol 20 (4) ◽  
pp. 669-676 ◽  
Author(s):  
Nobuyuki Shimizu ◽  
Ken-ichi Inada ◽  
Hayao Nakanishi ◽  
Tetsuya Tsukamoto ◽  
Yuzuru Ikehara ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Glandular Stomach ◽  
Mongolian Gerbils ◽  
Chemical Carcinogens ◽  
Stomach Carcinogenesis
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