scholarly journals Expression of concern: Characterization of a novel epigenetically-silenced, growth-suppressive gene,ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma

2008 ◽  
Vol 123 (2) ◽  
pp. 401-408 ◽  
Author(s):  
Hong Lok Lung ◽  
Paulisally Hau Yi Lo ◽  
Dan Xie ◽  
Suneel S. Apte ◽  
Arthur Kwok Leung Cheung ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastases ◽  
Node Metastases

scholarly journals PD11-12 GENOMIC CHARACTERIZATION OF PAIRED CYSTECTOMY AND LYMPH NODE METASTASES IN BLADDER UROTHELIAL CARCINOMA

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Victor McPherson ◽  
Bernard H. Bochner ◽  
Shawn Dason ◽  
Priscilla Baez ◽  
Eugene Pietzak ◽  
...  
Keyword(s):  
Lymph Node ◽  
Urothelial Carcinoma ◽  
Lymph Node Metastases ◽  
Bladder Urothelial Carcinoma ◽  
Genomic Characterization ◽  
Node Metastases

Incidence of small lymph node metastases in patients with nasopharyngeal carcinoma: Clinical implications for prognosis and treatment

Head & Neck ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 305-310 ◽  
Author(s):  
Peng Xu ◽  
Yanmei Min ◽  
Pierre Blanchard ◽  
Mei Feng ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastases ◽  
Clinical Implications ◽  
Node Metastases ◽  
Small Lymph Node

scholarly journals Genomic and Transcriptomic Characterization of Papillary Microcarcinomas With Lateral Neck Lymph Node Metastases

2019 ◽  
Vol 104 (10) ◽  
pp. 4889-4899 ◽  
Author(s):  
Dilmi Perera ◽  
Ronald Ghossein ◽  
Niedzica Camacho ◽  
Yasin Senbabaoglu ◽  
Venkatraman Seshan ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Predictive Value ◽  
Nodal Metastases ◽  
Lateral Neck ◽  
Nodal Disease ◽  
Node Metastases ◽  
Papillary Microcarcinomas ◽  
Molecular Classifier

Abstract Context Most papillary microcarcinomas (PMCs) are indolent and subclinical. However, as many as 10% can present with clinically significant nodal metastases. Objective and Design Characterization of the genomic and transcriptomic landscape of PMCs presenting with or without clinically important lymph node metastases. Subjects and Samples Formalin-fixed paraffin-embedded PMC samples from 40 patients with lateral neck nodal metastases (pN1b) and 71 patients with PMC with documented absence of nodal disease (pN0). Outcome Measures To interrogate DNA alterations in 410 genes commonly mutated in cancer and test for differential gene expression using a custom NanoString panel of 248 genes selected primarily based on their association with tumor size and nodal disease in the papillary thyroid cancer TCGA project. Results The genomic landscapes of PMC with or without pN1b were similar. Mutations in TERT promoter (3%) and TP53 (1%) were exclusive to N1b cases. Transcriptomic analysis revealed differential expression of 43 genes in PMCs with pN1b compared with pN0. A random forest machine learning–based molecular classifier developed to predict regional lymph node metastasis demonstrated a negative predictive value of 0.98 and a positive predictive value of 0.72 at a prevalence of 10% pN1b disease. Conclusions The genomic landscape of tumors with pN1b and pN0 disease was similar, whereas 43 genes selected primarily by mining the TCGA RNAseq data were differentially expressed. This bioinformatics-driven approach to the development of a custom transcriptomic assay provides a basis for a molecular classifier for pN1b risk stratification in PMC.

scholarly journals Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases

Neoplasia ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 140-151 ◽  
Author(s):  
Ann-Kathrin Müller ◽  
Melanie Föll ◽  
Bianca Heckelmann ◽  
Selina Kiefer ◽  
Martin Werner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Primary Tumors ◽  
Node Metastases
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