scholarly journals Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma

2008 ◽  
Vol 123 (2) ◽  
pp. 395-400 ◽  
Author(s):  
Jean-Jacques Patard ◽  
Patricia Fergelot ◽  
Pierre I. Karakiewicz ◽  
Tobias Klatte ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Mutation ◽  
Renal Cell ◽  
Clear Cell ◽  
Tumor Aggressiveness ◽  
Poor Survival ◽  
Cell Renal Cell Carcinoma ◽  
Vhl Gene ◽  
Caix Expression

scholarly journals 216: Low CAIX Expression and Absence of VHL Gene Mutation are Associated with Tumor Aggressiveness and Poor Survival in Patients with Renal Cell Carcinoma (RCC)

2007 ◽  
Vol 177 (4S) ◽  
pp. 72-73
Author(s):  
Jean-Jacques Patard ◽  
Quoc-Dien Trinh ◽  
Pierre I. Karakiewicz ◽  
Patricia Fergelot ◽  
Nathalie Rioux-Leclercq ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Mutation ◽  
Renal Cell ◽  
Tumor Aggressiveness ◽  
Poor Survival ◽  
Vhl Gene ◽  
Caix Expression

scholarly journals High expression of F2RL3 correlates with aggressive features and poor survival in clear cell renal cell carcinoma

2018 ◽  
Vol 9 (18) ◽  
pp. 3400-3406
Author(s):  
Dalong Cao ◽  
Yuanyuan Qu ◽  
Xuan Zhang ◽  
Fujiang Xu ◽  
Shuxian Zhou ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
High Expression ◽  
Poor Survival ◽  
Cell Renal Cell Carcinoma

scholarly journals Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma

Neoplasma ◽  
2012 ◽  
Vol 59 (06) ◽  
pp. 599-605 ◽  
Author(s):  
Y. W. YE ◽  
Z. M. JIANG ◽  
W. H. LI ◽  
Z. S. LI ◽  
Y. H. HAN ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Poor Survival ◽  
Down Regulation ◽  
Cell Renal Cell Carcinoma

scholarly journals Clear Cell Renal Cell Carcinoma: Gene Expression Analyses Identify a Potential Signature for Tumor Aggressiveness

2005 ◽  
Vol 11 (14) ◽  
pp. 5128-5139 ◽  
Author(s):  
Farhad Kosari ◽  
Alexander S. Parker ◽  
Dagmar Marie Kube ◽  
Christine M. Lohse ◽  
Bradley C. Leibovich ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Tumor Aggressiveness ◽  
Cell Renal Cell Carcinoma ◽  
Gene Expression Analyses

scholarly journals MP78-02 URINARY COLLECTING SYSTEM INVASION IS ASSOCIATED WITH POOR SURVIVAL IN CLEAR CELL RENAL CELL CARCINOMA PATIENTS

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
George Bailey ◽  
Stephen Boorjian ◽  
Matthew Ziegelmann ◽  
Mary Westerman ◽  
Christine Lohse ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Poor Survival ◽  
Cell Renal Cell Carcinoma ◽  
Collecting System ◽  
Urinary Collecting System

scholarly journals Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations

2020 ◽  
Author(s):  
Hyun Jung Lee ◽  
Dong Hoon Shin ◽  
Joon Young Park ◽  
So Young Kim ◽  
Chung Su Hwang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Mutation ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Tumors ◽  
Renal Neoplasm ◽  
Reverse Polarity ◽  
Cell Renal Cell Carcinoma ◽  
Exon 2

Abstract Background: The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal neoplasm with reverse polarity (PRNRP) with comprehensive immunohistochemical and molecular characterization using next-generation sequencing (NGS). Case presentation: A 61-year-old man was incidentally found to have a left renal mass on imaging studies performed for workup of left back pain and urine color change for one week. A laparoscopic left radical nephrectomy was performed. Gross examination showed lobulated masses measuring 5.6 × 4.0 × 3.3 cm in the upper to mid pole and 1.1 × 1.0 × 1.0 cm in the lower pole. Microscopic findings revealed these to be two different separate masses of clear cell renal cell carcinoma and papillary renal neoplasm with reverse polarity. NGS analyses revealed KRAS gene mutation (c.35G>T/p.G12V in exon 2) in the papillary renal neoplasm with reverse polarity, with PIK3CA gene mutation restricted to the clear cell renal cell carcinoma (c.1624G>A/p.E542K in exon 10).Conclusions: We report here an extraordinarily rare case of synchronous renal tumors of papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma. We identified simultaneous KRAS and PIK3CA mutations in two different renal masses in the same kidney for the first time. New pathologic assessment with comparative molecular analysis of mutational profiles may be helpful for tumor studies.

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