scholarly journals VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma

2008 ◽  
Vol 122 (11) ◽  
pp. 2471-2481 ◽  
Author(s):  
Armin Thelen ◽  
Arne Scholz ◽  
Christoph Benckert ◽  
Zofia von Marschall ◽  
Maik Schröder ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lymphatic Spread

Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

2014 ◽  
Vol 136 (11) ◽  
pp. 2556-2565 ◽  
Author(s):  
Dong Zhao ◽  
Xi-Dai Long ◽  
Tian-Fei Lu ◽  
Tao Wang ◽  
Wei-Wei Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Growth ◽  
Orthotopic Mouse Model

320 VEGF-D Promotes Tumor Growth and Lymphatic Spread in Hepatocellular Carcinoma

2008 ◽  
Vol 134 (4) ◽  
pp. A-46
Author(s):  
Armin Thelen ◽  
Arne Scholz ◽  
Christoph Benckert ◽  
Maik Schröder ◽  
Peter Neuhaus ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Lymphatic Spread

scholarly journals Yttrium-90-Labeled Anti-Glypican 3 Radioimmunotherapy Halts Tumor Growth in an Orthotopic Xenograft Model of Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Andrew D. Ludwig ◽  
Kevin P. Labadie ◽  
Y. David Seo ◽  
Donald K. Hamlin ◽  
Holly M. Nguyen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Growth ◽  
The United States ◽  
High Energy ◽  
Cell Surface Receptor ◽  
Beta Particle ◽  
Orthotopic Xenograft ◽  
Highly Correlated ◽  
Yttrium 90

Hepatocellular carcinoma (HCC) is the second most lethal malignancy globally and is increasing in incidence in the United States. Unfortunately, there are few effective systemic treatment options, particularly for disseminated disease. Glypican-3 (GPC3) is a proteoglycan cell surface receptor overexpressed in most HCCs and provides a unique target for molecular therapies. We have previously demonstrated that PET imaging using a 89Zr-conjugated monoclonal anti-GPC3 antibody (αGPC3) can bind to minute tumors and allow imaging with high sensitivity and specificity in an orthotopic xenograft mouse model of HCC and that serum alpha-fetoprotein (AFP) levels are highly correlated with tumor size in this model. In the present study, we conjugated 90Y, a high-energy beta-particle-emitting radionuclide, to our αGPC3 antibody to develop a novel antibody-directed radiotherapeutic approach for HCC. Luciferase-expressing HepG2 human hepatoblastoma cells were orthotopically implanted in the livers of athymic nude mice, and tumor establishment was verified at 6 weeks after implantation by bioluminescent imaging and serum AFP concentration. Tumor burden by bioluminescence and serum AFP concentration was highly correlated in our model. Yttrium-90 was conjugated to αGPC3 using the chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and injected via the tail vein into the experimental mice at a dose of 200 μCi/mouse or 300 μCi/mouse. Control mice received DOTA-αGPC3 without radionuclide. At 30 days after a single dose of the radioimmunotherapy agent, mean serum AFP levels in control animals increased dramatically, while animals treated with 200 μCi only experienced a minor increase, indicating cessation of tumor growth, and animals treated with 300 μCi experienced a reduction in serum AFP concentration, indicating tumor shrinkage. Mean tumor-bearing liver weight in control animals was also significantly greater than that in animals that received either dose of 90Y-αGPC3. These results were achieved without significant toxicity as measured by body condition scoring and body weight. The results of this preclinical pilot demonstrate that GPC3 can be used as a target for radioimmunotherapy in an orthotopic mouse model of HCC and may be a target of clinical significance, particularly for disseminated HCC.

scholarly journals Small Interfering RNAs Induce Target-Independent Inhibition of Tumor Growth and Vasculature Remodeling in a Mouse Model of Hepatocellular Carcinoma

2010 ◽  
Vol 177 (6) ◽  
pp. 3192-3201 ◽  
Author(s):  
Mathieu Bergé ◽  
Philippe Bonnin ◽  
Eric Sulpice ◽  
José Vilar ◽  
David Allanic ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Growth ◽  
Small Interfering Rnas ◽  
Inhibition Of Tumor Growth

scholarly journals miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model

2018 ◽  
Vol 11 ◽  
pp. 485-493 ◽  
Author(s):  
Elisa Callegari ◽  
Lucilla D’Abundo ◽  
Paola Guerriero ◽  
Carolina Simioni ◽  
Bahaeldin K. Elamin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Tumor Growth ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth
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