scholarly journals Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model

2007 ◽  
Vol 122 (8) ◽  
pp. 1794-1802 ◽  
Author(s):  
Oliver M. Grauer ◽  
Roger P.M. Sutmuller ◽  
Wendy van Maren ◽  
Joannes F.M. Jacobs ◽  
Erik Bennink ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Tumor Lysate ◽  
Glioma Model ◽  
Murine Glioma

scholarly journals Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Wim Maes ◽  
Tina Verschuere ◽  
Anaïs Van Hoylandt ◽  
Louis Boon ◽  
Stefaan Van Gool
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Myeloid Cells ◽  
Suppressor Cells ◽  
Tumor Challenge ◽  
Glioma Model ◽  
Infiltrating Lymphocytes ◽  
The Brain ◽  
Murine Glioma

The recruitment and activation of regulatory T cells (Tregs) in the micro-environment of malignant brain tumors has detrimental effects on antitumoral immune responses. Hence, local elimination of Tregs within the tumor micro-environment represents a highly valuable tool from both a fundamental and clinical perspective. In the syngeneic experimental GL261 murine glioma model, Tregs were prophylactically eliminated through treatment with PC61, an anti-CD25 mAb. This resulted in specific elimination of CD4+CD25hiFoxp3+ Treg within brain-infiltrating lymphocytes and complete protection against subsequent orthotopic GL261 tumor challenge. Interestingly, PC61-treated mice also showed a pronounced infiltration of CD11b+ myeloid cells in the brain. Phenotypically, these cells could not be considered as Gr-1+ myeloid-derived suppressor cells (MDSC) but were identified as F4/80+ macrophages and granulocytes.

scholarly journals Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+Regulatory T Cells

2009 ◽  
Vol 182 (5) ◽  
pp. 2795-2807 ◽  
Author(s):  
Ingrid E. Dumitriu ◽  
Donald R. Dunbar ◽  
Sarah E. Howie ◽  
Tariq Sethi ◽  
Christopher D. Gregory
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Dendritic Cells ◽  
Tgf Β1

scholarly journals Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells

2010 ◽  
Vol 11 (1) ◽  
pp. 33 ◽  
Author(s):  
Young Son ◽  
Sung Ahn ◽  
Gi Kim ◽  
Yang Moon ◽  
Sang Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells

scholarly journals Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157822 ◽  
Author(s):  
Nicolas Goudin ◽  
Pascal Chappert ◽  
Jérome Mégret ◽  
David-Alexandre Gross ◽  
Benedita Rocha ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Effector T Cells
Sign in / Sign up

Export Citation Format

Share Document