scholarly journals Transcriptional regulation of humansurvivinby early growth response (Egr)-1 transcription factor

2007 ◽  
Vol 122 (6) ◽  
pp. 1278-1287 ◽  
Author(s):  
Mandy Wagner ◽  
Karin Schmelz ◽  
Bernd Dörken ◽  
Ingo Tamm
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Growth Response ◽  
Early Growth ◽  
Early Growth Response

scholarly journals Toxoplasma gondii Rhoptry Discharge Correlates with Activation of the Early Growth Response 2 Host Cell Transcription Factor

2008 ◽  
Vol 76 (10) ◽  
pp. 4703-4712 ◽  
Author(s):  
Eric D. Phelps ◽  
Kristin R. Sweeney ◽  
Ira J. Blader
Keyword(s):  
Transcription Factor ◽  
Toxoplasma Gondii ◽  
Host Cell ◽  
Growth Response ◽  
Neospora Caninum ◽  
Early Growth ◽  
Apicomplexan Parasite ◽  
Host Cells ◽  
Early Growth Response ◽  
Cell Extracts

ABSTRACT Toxoplasma gondii is a ubiquitous apicomplexan parasite that can cause severe disease in fetuses and immune-compromised patients. Rhoptries, micronemes, and dense granules, which are secretory organelles unique to Toxoplasma and other apicomplexan parasites, play critical roles in parasite growth and virulence. To understand how these organelles modulate infected host cells, we sought to identify host cell transcription factors triggered by their release. Early growth response 2 (EGR2) is a host cell transcription factor that is rapidly upregulated and activated in Toxoplasma-infected cells but not in cells infected with the closely related apicomplexan parasite Neospora caninum. EGR2 upregulation occurred only when live parasites were in direct contact with the host cell and not from exposure to cell extracts that contain dense granule or micronemal proteins. When microneme-mediated attachment was blocked by pretreating parasites with a calcium chelator, EGR2 expression was significantly reduced. In contrast, when host cells were infected with parasites in the presence of cytochalasin D, which allows rhoptry secretion but prevents parasite invasion, EGR2 was activated. Finally, we demonstrate that Toxoplasma activation of host p38 mitogen-activated protein kinase is necessary but not sufficient for EGR2 activation. Collectively, these data indicate that EGR2 is specifically upregulated by a parasite-derived secreted factor that is most likely a resident rhoptry protein.

scholarly journals Transcription Factor Early Growth Response 3 Is Associated with the TGF-β1 Expression and the Regulatory Activity of CD4-Positive T Cells In Vivo

2013 ◽  
Vol 191 (5) ◽  
pp. 2351-2359 ◽  
Author(s):  
Shuji Sumitomo ◽  
Keishi Fujio ◽  
Tomohisa Okamura ◽  
Kaoru Morita ◽  
Kazuyoshi Ishigaki ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Growth Response ◽  
Early Growth ◽  
Regulatory Activity ◽  
Early Growth Response ◽  
Tgf Β1

The differential expression of the blood group P1 -A4GALT and P2 -A4GALT alleles is stimulated by the transcription factor early growth response 1

Transfusion ◽  
2018 ◽  
Vol 58 (4) ◽  
pp. 1054-1064 ◽  
Author(s):  
Chih-Chun Yeh ◽  
Ching-Jin Chang ◽  
Yuh-Ching Twu ◽  
Shu-Ting Hung ◽  
Yi-Jui Tsai ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Differential Expression ◽  
Blood Group ◽  
Growth Response ◽  
Early Growth ◽  
Early Growth Response ◽  
Early Growth Response 1

scholarly journals Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells

2011 ◽  
Vol 8 (1) ◽  
pp. 262 ◽  
Author(s):  
Gautam R Bedadala ◽  
Jayavardhana R Palem ◽  
Lorna Graham ◽  
James M Hill ◽  
Harris E McFerrin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Response ◽  
Early Growth ◽  
Early Growth Response ◽  
Corneal Cells ◽  
Early Growth Response 1 ◽  
Multifunctional Transcription Factor ◽  
Hsv 1
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