scholarly journals Reactive oxygen species-dependent EndoG release mediates cisplatin-induced caspase-independent apoptosis in human head and neck squamous carcinoma cells

2007 ◽  
Vol 122 (3) ◽  
pp. 672-680 ◽  
Author(s):  
Jong Soo Kim ◽  
Ji Hae Lee ◽  
Won Wook Jeong ◽  
Dae Hwa Choi ◽  
Hee Jeong Cha ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Head And Neck ◽  
Reactive Oxygen ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Carcinoma Cells ◽  
Oxygen Species ◽  
Squamous Carcinoma Cells

Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells

2010 ◽  
Vol 44 (8) ◽  
pp. 913-924 ◽  
Author(s):  
Yojiro Maehata ◽  
Shigeyuki Ozawa ◽  
Kyo Kobayashi ◽  
Yasumasa Kato ◽  
Fumihiko Yoshino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Human Head ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species

scholarly journals Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 208
Author(s):  
Hong-Gui Xu ◽  
Viktor Reshetnikov ◽  
Marit Wondrak ◽  
Lisa Eckhardt ◽  
Leoni A. Kunz-Schughart ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Cells ◽  
Water Solubility ◽  
Reactive Oxygen ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Oxygen Species ◽  
Squamous Carcinoma Cells ◽  
Close Proximity ◽  
Ic50 Values

Radiotherapy (RT) efficacy can be improved by using radiosensitizers, i.e., drugs enhancing the effect of ionizing radiation (IR). One of the side effects of RT includes damage of normal tissue in close proximity to the treated tumor. This problem can be solved by applying cancer specific radiosensitizers. N-Alkylaminoferrocene-based (NAAF) prodrugs produce reactive oxygen species (ROS) in cancer cells, but not in normal cells. Therefore, they can potentially act as cancer specific radiosensitizers. However, early NAAF prodrugs did not exhibit this property. Since functional mitochondria are important for RT resistance, we assumed that NAAF prodrugs affecting mitochondria in parallel with increasing intracellular ROS can potentially exhibit synergy with RT. We applied sequential Cu+-catalyzed alkyne-azide cycloadditions (CuAAC) to obtain a series of NAAF derivatives with the goal of improving anticancer efficacies over already existing compounds. One of the obtained prodrugs (2c) exhibited high anticancer activity with IC50 values in the range of 5–7.1 µM in human ovarian carcinoma, Burkitt’s lymphoma, pancreatic carcinoma and T-cell leukemia cells retained moderate water solubility and showed cancer specificity. 2c strongly affects mitochondria of cancer cells, leading to the amplification of mitochondrial and total ROS production and thus causing cell death via necrosis and apoptosis. We observed that 2c acts as a radiosensitizer in human head and neck squamous carcinoma cells. This is the first demonstration of a synergy between the radiotherapy and NAAF-based ROS amplifiers.

scholarly journals Linalool Induces Reactive Oxygen Species Mediated Apoptosis in Human Oral Squamous Carcinoma Cells

2021 ◽  
Vol 83 (5) ◽  
Author(s):  
Rajangam Pushpalatha ◽  
Ganapathy Sindhu ◽  
Ramalingam Sharmila ◽  
G. Tamizharasi ◽  
Lakshmanan Vennila ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Oxygen Species ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

Reovirus oncolysis in human head and neck squamous carcinoma cells

2004 ◽  
Vol 31 (4) ◽  
pp. 407-412 ◽  
Author(s):  
Y IKEDA ◽  
G NISHIMURA ◽  
S YANOMA ◽  
A KUBOTA ◽  
M FURUKAWA ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells
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