scholarly journals Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene,O6-alkylguanine–DNA alkyltransferase

2008 ◽  
Vol 122 (4) ◽  
pp. 791-795 ◽  
Author(s):  
Philip A.J. Crosbie ◽  
Gail McGown ◽  
Mary R. Thorncroft ◽  
Paul N.S. O'Donnell ◽  
Philip V. Barber ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Nucleotide Polymorphisms ◽  
Repair Gene ◽  
Single Nucleotide ◽  
First Intron ◽  
Dna Repair Gene ◽  
Dna Alkyltransferase

DNA repair gene XPD polymorphism and lung cancer risk: a meta-analysis

Lung Cancer ◽  
2004 ◽  
Vol 46 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Z. Hu ◽  
Q. Wei ◽  
X. Wang ◽  
H. Shen
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Repair Gene ◽  
Dna Repair Gene

Comprehensive assessment of the association between DNA repair gene XRCC3 rs861539 C/T polymorphism and lung cancer risk

Tumor Biology ◽  
2013 ◽  
Vol 34 (5) ◽  
pp. 2521-2527 ◽  
Author(s):  
Gang Ding ◽  
Weiguo Xu ◽  
Hongwei Hua ◽  
Qian Huang ◽  
Hongxiang Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Comprehensive Assessment ◽  
Repair Gene ◽  
Dna Repair Gene

Abstract 4597: A novel variant in DNA repair gene GTF2H4 is associated with lung cancer risk: A reanalysis of GWAS datasets from the TRICL consortium

2015 ◽  
Author(s):  
Qingyi Wei ◽  
Hongliang Liu ◽  
Zhensheng Liu ◽  
Christopher I. Amos ◽  
Jennifer A. Doherty ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Novel Variant

DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: A meta-analysis

2015 ◽  
Vol 102 (4) ◽  
pp. 332-339 ◽  
Author(s):  
Liu Bei ◽  
Tan Xiao-dong ◽  
Gao Yu-fang ◽  
Sun Jian-ping ◽  
Ying Zhao-yu
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Xrcc3 Thr241met

miR-146a and miR-196a-2 genes polymorphisms and its circulating levels in lung cancer patients

2019 ◽  
Vol 166 (4) ◽  
pp. 323-329 ◽  
Author(s):  
Randa H Mohamed ◽  
Heba F Pasha ◽  
Doaa M Gad ◽  
Mostafa M Toam
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Lung Cancer Risk ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Lung Cancer Patients ◽  
Increased Risk ◽  
Increase Risk ◽  
Circulating Levels

AbstractRecently, MicroRNAs polymorphisms and their serum expression have been linked to increase risk of various cancers. The aim of this study was to elucidate the association between single nucleotide polymorphisms of miR-146a and miR-196a-2 and their serum expression and lung cancer risk. One hundred and twenty lung cancer patients and 120 health controls were included in this study. Genotyping and expression for miR-146a and miR-196a-2 were performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism and quantitative real-time PCR. Individuals carrying miR-146a CG and CC genotypes had significantly increased risk for lung cancer than those carrying miR-146a GG genotype. MiR-146a expression significantly decreased in miR-146a CG and CC genotypes carriers as compared with GG genotype carriers. MiR-196a-2 CT and TT genotypes were significantly associated with increased lung cancer while the highest expression of MiR-196a-2 was detected in miR-196a-2 CC genotype carriers. Serum miR-146a was significantly decreased in lung cancer patients while serum miR-196a-2 expression was significantly increased in lung cancer patients. In conclusion, miR-146a and miR-196a-2 genes polymorphisms and their circulating levels were associated with lung cancer risk in Egyptians and may be helpful in early detection of lung cancer.

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