scholarly journals Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis

2007 ◽  
Vol 121 (12) ◽  
pp. 2596-2605 ◽  
Author(s):  
Jian-feng Lin ◽  
Jun Xu ◽  
Hong-yu Tian ◽  
Xia Gao ◽  
Qing-xi Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proteomic Analysis ◽  
Needle Biopsy ◽  
Cancer Biomarkers ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens

scholarly journals Is there a correlation between the aggressiveness of chronic asymptomatic prostatitis NIH category IV and the Gleason score in patients with prostate cancer?

2019 ◽  
Vol 14 (11) ◽  
Author(s):  
Erdogan Aglamis ◽  
Cavit Ceylan ◽  
Mustafa Akin
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Gleason Score ◽  
Needle Biopsy ◽  
Newly Diagnosed ◽  
Prostate Needle Biopsy ◽  
Retrospective Design ◽  
Biopsy Specimens ◽  
Grade 3 ◽  
Prostatic Inflammation

Introduction: We evaluated the correlation between the International Society of Urological Pathology (ISUP) grades and the aggressiveness grades of prostate inflammation in newly diagnosed prostate cancer patients with chronic asymptomatic prostatitis National Institiutes of Health (NIH) category IV (CAPNIHIV). Methods: The study comprised 357 consecutive patients with prostate cancer in whom a cancer diagnosis had been made via a prostate needle biopsy. Histological sections of the prostate biopsy specimens of the patients were reviewed and scored. Prostatic inflammation was scored using the aggressiveness grade of inflammation. The associations between the ISUP grades and the aggressiveness grades of inflammation were analyzed using logistic regression. The limitations of the study were its retrospective design and the limited number of cases. Results: In 110 (31%) patients, CAPNIHIV was detected: 56 (51%) patients had a grade 0 aggressiveness score, 34 (31%) patients had a grade 1 aggressiveness score, and 20 (18%) patients had a grade 2 aggressiveness score. The patients who had prostatic inflammation had a 1.65 times (95% confidence interval [CI] 1.05–2.61) greater likelihood of a high ISUP grade (grade ≥3) compared with the patients who did not have prostatic inflammation. The association between the ISUP grade and the aggressiveness grade of inflammation was more pronounced for a grade 2 aggressiveness score (n= 20; odds ratio 2.97; 95% CI 1.14–7.71). Conclusions: In prostate cancer patients with CAPNIHIV, there was a positive correlation between the inflammation aggressiveness grade and the ISUP grade. The aggressiveness of intraprostatic inflammation may be an important morphological factor affecting the Gleason score.

Morphologic Criteria for the Diagnosis of Prostatic Adenocarcinoma in Needle Biopsy Specimens

2002 ◽  
Vol 126 (5) ◽  
pp. 554-561 ◽  
Author(s):  
Murali Varma ◽  
Min W. Lee ◽  
Pheroze Tamboli ◽  
Richard J. Zarbo ◽  
Rafael E. Jimenez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Criteria ◽  
Needle Biopsy ◽  
Perineural Invasion ◽  
Single Case ◽  
Needle Core Biopsy ◽  
Prostate Needle Biopsy ◽  
Biopsy Specimens ◽  
Retraction Clefting ◽  
Hematoxylin Eosin

Abstract Context.—The diagnosis of prostate adenocarcinoma in needle core biopsy specimens is based on multiple diagnostic criteria and supportive features, most of which have been defined mainly from observations in transurethral resection and prostatectomy specimens. There is little information on the frequency with which diagnostic and supportive features of prostate cancer occur within benign glands. The few reports dealing with diagnostic criteria of cancer in needle biopsies have been largely confined to analysis of selected cases that posed particular diagnostic difficulty. Objective.—To analyze the frequency with which numerous diagnostic or supportive features of prostate cancer occur in an unselected, consecutively performed series of 18-gauge prostate needle biopsy specimens. Design.—Two hundred fifty consecutive 18-gauge prostate needle biopsy specimens (150 malignant and 100 benign) were evaluated, using hematoxylin-eosin–stained histologic sections. Results.—The frequency of the histologic features in malignant and benign glands was as follows: prominent nucleoli (94% and 25% of malignant and benign specimens, respectively), marginated nucleoli (88% and 7%), multiple nucleoli (64% and 0%), blue-tinged mucinous secretions (52% and 0%), intraluminal crystalloids (40.6% and 1%), intraluminal amorphous eosinophilic material (86.7% and 2%), collagenous micronodules (2% and 0%), glomerulations (15.3% and 0%), perineural invasion (22% and 0%), retraction clefting (38.6% and 7%), and invasion of fat (0.7% and 0%). Conclusions.—Since not all diagnostic or supportive features of cancer are evident in any single case of cancer, particularly in needle biopsy specimens in which sampling is limited, awareness of these data would be helpful in the assessment of small foci of atypical glands being considered for cancer.

Atypical Small Acinar Proliferation in the Prostate: Clinical Significance in 2006

2006 ◽  
Vol 130 (7) ◽  
pp. 952-957 ◽  
Author(s):  
David G. Bostwick ◽  
Isabelle Meiers
Keyword(s):  
Prostate Cancer ◽  
Clinical Significance ◽  
Needle Biopsy ◽  
Invasive Carcinoma ◽  
Repeat Biopsy ◽  
Prostate Needle Biopsy ◽  
Atypical Small Acinar Proliferation ◽  
Biopsy Specimens ◽  
Diagnostic Threshold

Abstract About 2% of contemporary prostate needle biopsy specimens contain collections of small acini that are suspicious for cancer but that fall below the diagnostic threshold and are reported as atypical small acinar proliferation suspicious for but not diagnostic of malignancy. Prostate cancer has been identified in specimens from subsequent biopsies in up to 60% of cases of atypical small acinar proliferation, indicating that this finding is a significant predictor of cancer. Identification of atypical small acinar proliferation warrants repeat biopsy for concurrent or subsequent invasive carcinoma.

Detection of prostate cancer by alpha-methylacyl CoA racemase (P504S) in needle biopsy specimens previously reported as negative for malignancy

2006 ◽  
Vol 48 (6) ◽  
pp. 668-673 ◽  
Author(s):  
B M Carswell ◽  
B A Woda ◽  
X Wang ◽  
C Li ◽  
K Dresser ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Needle Biopsy ◽  
Biopsy Specimens

A Model to Predict Prostate Cancer After Atypical Findings in Initial Prostate Needle Biopsy

2011 ◽  
Vol 185 (4) ◽  
pp. 1240-1245 ◽  
Author(s):  
Jennifer L. Merrimen ◽  
Glenn Jones ◽  
Sundus A.B. Hussein ◽  
Chung S. Leung ◽  
Linda R. Kapusta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Needle Biopsy ◽  
Prostate Needle Biopsy

Prostate Cancer With Tertiary Gleason Pattern 5 in Prostate Needle Biopsy

2009 ◽  
Vol 33 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Kiril Trpkov ◽  
Jianguo Zhang ◽  
Melissa Chan ◽  
Bernhard J.C. Eigl ◽  
Asli Yilmaz
Keyword(s):  
Prostate Cancer ◽  
Needle Biopsy ◽  
Prostate Needle Biopsy ◽  
Gleason Pattern
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