scholarly journals DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer

2007 ◽  
Vol 120 (8) ◽  
pp. 1689-1695 ◽  
Author(s):  
Shunji Matsumura ◽  
Naohide Oue ◽  
Yoshitsugu Mitani ◽  
Yasuhiko Kitadai ◽  
Wataru Yasui
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Dna Demethylation ◽  
Vascular Endothelial ◽  
Factor C ◽  
Endothelial Growth Factor

Vascular endothelial growth factor–C gene expression in papillary and follicular thyroid carcinomas

Surgery ◽  
1999 ◽  
Vol 126 (6) ◽  
pp. 1056-1062 ◽  
Author(s):  
Peter T. Fellmer ◽  
Kanji Sato ◽  
Reiko Tanaka ◽  
Takahiro Okamoto ◽  
Yoichiro Kato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Thyroid Carcinomas ◽  
Factor C ◽  
Endothelial Growth Factor

Vascular endothelial growth factor-C and -D expression correlates with lymph node micrometastasis in pN0 early gastric cancer

2009 ◽  
Vol 99 (3) ◽  
pp. 148-153 ◽  
Author(s):  
Takaaki Arigami ◽  
Shoji Natsugoe ◽  
Yoshikazu Uenosono ◽  
Shigehiro Yanagita ◽  
Katsuhiko Ehi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Lymph Node ◽  
Growth Factor ◽  
Early Gastric Cancer ◽  
Vascular Endothelial ◽  
Lymph Node Micrometastasis ◽  
Factor C ◽  
Endothelial Growth Factor

Vascular Endothelial Growth Factor C Gene Expression Is Closely Related to Invasion Phenotype in Gynecological Tumor Cells

2001 ◽  
Vol 82 (1) ◽  
pp. 162-166 ◽  
Author(s):  
Masatsugu Ueda ◽  
Yoshito Terai ◽  
Koji Kumagai ◽  
Ken Ueki ◽  
Hiroyuki Yamaguchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumor Cells ◽  
Vascular Endothelial ◽  
Gynecological Tumor ◽  
Factor C ◽  
Endothelial Growth Factor

scholarly journals Expression and Significances of Contactin-1 in Human Gastric Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Ji-Wei Yu ◽  
Sheng-Hua Wu ◽  
Rui-qi Lu ◽  
Ju-gang Wu ◽  
Xiao-Chun Ni ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Lymph Node Involvement ◽  
Lymphatic Invasion ◽  
Human Gastric Cancer ◽  
Vascular Endothelial ◽  
Factor C ◽  
Endothelial Growth Factor

Background. This study aimed at determining the relationship between vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor receptor-3 (VEGFR-3), and contactin-1 (CNTN-1) expression in gastric cancer (GC).Methods. The expression level of CNTN-1 mRNA and CNTN-1 protein of 33 cases was determined using RT-PCR and Western Blot. And 105 cases were immunohistochemically examined for VEGF-C, VEGFR-3, and CNTN-1 expressions. Assessment of lymphatic vessel density (LVD) was also performed by D2-40 immunostaining. Then we analyzed the relationships between VEGF-C, VEGFR-3, and CNTN-1, as well as their correlations with clinicopathologic features, LVD, and survival time.Results. The positivity rate of VEGF-C, VEGFR-3, and CNTN-1 in primary tumor was 56.19%, 64.76%, and 58.09%. The expression of CNTN-1 significantly correlated with VEGF-C (P<0.001) and VEGFR-3 (P<0.001). All of them were closely related to TNM stage, lymphatic invasion, and lymph node involvement (P<0.05). LVD was significantly correlated with VEGF-C (P=0.001), VEGFR-3 (P=0.011), and CNTN-1 expression (P<0.001). VEGF-C, VEGFR-3, and CNTN-1 expression significantly associated with poorer prognosis (P<0.001,P=0.034,P=0.012, resp.).Conclusion. CNTN-1 associated with VEGF-C and VEGFR-3 expression in GC. All of them correlated with lymphatic metastasis, which might play an important role in the lymphatic invasion via lymphangiogenesis pathway in GC.

Sign in / Sign up

Export Citation Format

Share Document