scholarly journals Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: The combined effects of bortezomib and interferon-γ on the presentation of a cryptic epitope

2006 ◽  
Vol 120 (3) ◽  
pp. 594-604 ◽  
Author(s):  
Satoko Morishima ◽  
Yoshiki Akatsuka ◽  
Akihiro Nawa ◽  
Eisei Kondo ◽  
Tohru Kiyono ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Interferon Γ ◽  
Combined Effects ◽  
Human Papillomavirus Type 16 ◽  
Cryptic Epitope

Studies on in Vivo Induction of Cytotoxic T Lymphocyte Responses by Synthetic Peptides from E6 and E7 Oncoproteins of Human Papillomavirus Type 16

1995 ◽  
Vol 8 (3) ◽  
pp. 165-174 ◽  
Author(s):  
ASIS K. SARKAR ◽  
GUILLERMO TORTOLERO-LUNA ◽  
PRAMOD N. NEHETE ◽  
RALPH B. ARLINGHAUS ◽  
MICHELE FOLLEN MITCHELL ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Synthetic Peptides ◽  
Cytotoxic T Lymphocyte ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7 ◽  
Lymphocyte Responses ◽  
In Vivo Induction

scholarly journals Cytotoxic T-Lymphocyte Responses to Human Papillomavirus Type 16 E5 and E7 Proteins and HLA-A*0201-Restricted T-Cell Peptides in Cervical Cancer Patients

2007 ◽  
Vol 81 (6) ◽  
pp. 2869-2879 ◽  
Author(s):  
Dai-Wei Liu ◽  
Yuh-Cheng Yang ◽  
Ho-Fan Lin ◽  
Mei-Fang Lin ◽  
Ya-Wen Cheng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
T Cell ◽  
Cancer Patients ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Hpv 16 ◽  
Human Papillomavirus Type 16 ◽  
E5 Protein ◽  
E7 Proteins

ABSTRACT Previously, we found that human papillomavirus type 16 (HPV-16) E5 protein is a tumor rejection antigen and can induce cytotoxic T-lymphocyte (CTL) activity. Therefore, in this study, human leukocyte antigen A*0201 (HLA-A*0201)-restricted human CTL epitopes of HPV-16 E5 protein were identified using a bioinformatics approach, and the abilities of these predicted peptides to induce an immune response in HLA-A*0201 transgenic mice were confirmed by assaying E5-specific CTLs and in vitro-generated CTLs from normal peripheral blood T lymphocytes of HLA-A2-positive human donors. Second, the CTL responses to HLA-A*0201 CTL epitopes (E5 63-71 and E7 11-20) were examined in HPV-16-infected patients with HLA-A2. Third, the effect of HLA-A-type alleles on CTL activities in response to the entire E5 and E7 proteins was examined in cervical cancer patients. E5 and E7 peptides (but not the whole proteins) stimulated E5- and E7-specific CTL recall responses in HPV-16- and HLA-A2-positive cervical cancer patients, and HPV-16 E5 and E7 proteins stimulated naïve T cells in HPV-16-negative cervical cancer patients with HLA-A11 and -A24 haplotypes. In summary, this is the first demonstration that E5 63-71 is an HLA-A*0201-restricted T-cell epitope of HPV-16 E5.

scholarly journals Codon Modified Human Papillomavirus Type 16 E7 DNA Vaccine Enhances Cytotoxic T-Lymphocyte Induction and Anti-tumour Activity

Virology ◽  
2002 ◽  
Vol 301 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Wen Jun Liu ◽  
Fengguang Gao ◽  
Kong Nan Zhao ◽  
Weiming Zhao ◽  
Germain J.G. Fernando ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Vaccine ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Human Papillomavirus Type 16 ◽  
Anti Tumour Activity ◽  
Tumour Activity

Dendritic Cells as Carriers for a Cytotoxic T-Lymphocyte Epitope-Based Peptide Vaccine in Protection Against a Human Papillomavirus Type 16-Induced Tumor

1995 ◽  
Vol 18 (2) ◽  
pp. 86-94 ◽  
Author(s):  
Miriam A. Ossevoort ◽  
Mariet C. W. Feltkamp ◽  
Karin J. H. van Veen ◽  
Cornelis J. M. Melief ◽  
W. Martin Kast
Keyword(s):  
Dendritic Cells ◽  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Peptide Vaccine ◽  
Human Papillomavirus Type 16

scholarly journals Human Papillomavirus Type 16 E7 Oncoprotein Expressed in Peripheral Epithelium Tolerizes E7-Directed Cytotoxic T-Lymphocyte Precursors Restricted through Human (and Mouse) Major Histocompatibility Complex Class I Alleles

1999 ◽  
Vol 73 (7) ◽  
pp. 6166-6170 ◽  
Author(s):  
Tracy Doan ◽  
Karen Herd ◽  
Michael Street ◽  
Gregory Bryson ◽  
Germain Fernando ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Squamous Epithelium ◽  
Cytotoxic T Lymphocyte ◽  
Immunological Tolerance ◽  
Chimeric Mice ◽  
Human Papillomavirus Type 16 ◽  
Mouse Major Histocompatibility Complex ◽  
Ctl Responses

ABSTRACT Mice which coexpress human papillomavirus type 16 E7 and HLA A2.1 in peripheral squamous epithelium and thymic cortical epithelium are tolerant at the cytotoxic T-lymphocyte (CTL) level to E7 epitopes restricted through HLA A*0201 and H-2b (T. Doan, M. Chambers, M. Street, G. J. Fernando, K. Herd, P. Lambert, and R. Tindle, Virology 244:352–364, 1998). Here we used bone marrow-reconstituted radiation chimeras to distinguish whether E7-directed CTL tolerance was mediated peripherally by E7 expression in skin or centrally by E7 expression in thymus. In chimeric mice expressing E7 in skin and reconstituted with E7-naı̈ve bone marrow and E7-naı̈ve thymus, CTL responses to vaccine-administered E7 epitopes were not restored, i.e., the mice remained tolerant. In contrast, chimeric mice not expressing E7 in skin and reconstituted with E7-naı̈ve bone marrow and E7-expressing thymus had full E7-directed CTL responses. These results demonstrate that E7 protein expression in peripheral squamous epithelium is sufficient to tolerize the E7-directed CTL precursor repertoire. The data have implications for E7-mediated tumorigenesis and for the development of E7-based immunotherapeutic strategies, since peripheral immunological tolerance of tumor-associated antigens may create a barrier to effective immunotherapy.

scholarly journals Identification of a cytotoxic T-lymphocyte epitope in the human papillomavirus type 16 E2 protein.

1997 ◽  
Vol 78 (10) ◽  
pp. 2615-2620 ◽  
Author(s):  
J K√≥nya ◽  
V af Geijersstam ◽  
F Yuan ◽  
J Dillner ◽  
G Stuber ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
E2 Protein ◽  
Human Papillomavirus Type 16
Sign in / Sign up

Export Citation Format

Share Document