Soluble MIC is elevated in the serum of patients with pancreatic carcinoma diminishing γδ T cell cytotoxicity

2006 ◽  
Vol 119 (10) ◽  
pp. 2359-2365 ◽  
Author(s):  
Angela Märten ◽  
Marie von Lilienfeld-Toal ◽  
Markus W. Büchler ◽  
Jan Schmidt
Keyword(s):  
T Cell ◽  
Pancreatic Carcinoma ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
T Cell Cytotoxicity

scholarly journals Novel Bispecific Antibodies Increase γδ T-Cell Cytotoxicity against Pancreatic Cancer Cells

2014 ◽  
Vol 74 (5) ◽  
pp. 1349-1360 ◽  
Author(s):  
Hans-Heinrich Oberg ◽  
Matthias Peipp ◽  
Christian Kellner ◽  
Susanne Sebens ◽  
Sarah Krause ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
T Cell ◽  
Cancer Cells ◽  
Bispecific Antibodies ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
Pancreatic Cancer Cells ◽  
T Cell Cytotoxicity

scholarly journals Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1140 ◽  
Author(s):  
Hannah Jonescheit ◽  
Hans-Heinrich Oberg ◽  
Daniel Gonnermann ◽  
Martin Hermes ◽  
Vjola Sulaj ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Bispecific Antibody ◽  
Γδ T Cells ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
Ductal Pancreatic Adenocarcinoma ◽  
Ido Inhibitors ◽  
The Impact ◽  
T Cell Cytotoxicity

Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant gastrointestinal disease. The enzyme indoleamine-2,3-dioxgenase (IDO) is often overexpressed in PDAC and its downstream metabolite kynurenine has been reported to inhibit T cell activation and proliferation. Since γδ T cells are of high interest for T cell-based immunotherapy against PDAC, we studied the impact of IDO and kynurenine on γδ T cell cytotoxicity against PDAC cells. Methods: IDO expression was determined in PDAC cells by flow cytometry and Western blot analysis. PDAC cells were cocultured with γδ T cells in medium or were stimulated with phosphorylated antigens or bispecific antibody in the presence or absence of IDO inhibitors. Additionally, γδ T cells were treated with recombinant kynurenine. Read-out assays included degranulation, cytotoxicity and cytokine measurement as well as cell cycle analysis. Results: Since IDO overexpression was variable in PDAC, IDO inhibitors improved γδ T cell cytotoxicity only against some but not all PDAC cells. γδ T cell degranulation and cytotoxicity were significantly decreased after their treatment with recombinant kynurenine. Conclusions: Bispecific antibody drastically enhanced γδ T cell cytotoxicity against all PDAC cells, which can be further enhanced by IDO inhibitors against several PDAC cells, suggesting a striking heterogeneity in PDAC escape mechanisms towards γδ T cell-mediated anti-tumor response.

scholarly journals Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity

2015 ◽  
Vol 4 (3) ◽  
pp. e988460 ◽  
Author(s):  
Daniel Gonnermann ◽  
Hans-Heinrich Oberg ◽  
Christian Kellner ◽  
Matthias Peipp ◽  
Susanne Sebens ◽  
...  
Keyword(s):  
T Cell ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cyclooxygenase 2 ◽  
Ductal Adenocarcinoma ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
Adenocarcinoma Cells ◽  
T Cell Cytotoxicity

scholarly journals PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

2010 ◽  
Vol 80 (6) ◽  
pp. 838-845 ◽  
Author(s):  
Ludovic Martinet ◽  
Christine Jean ◽  
Gilles Dietrich ◽  
Jean-Jacques Fournié ◽  
Rémy Poupot
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Type I ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
T Cell Cytotoxicity

scholarly journals Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to γδ T Cell Cytotoxicity

2020 ◽  
Vol 11 ◽  
Author(s):  
Gabrielle M. Siegers ◽  
Indrani Dutta ◽  
Eun Young Kang ◽  
Jing Huang ◽  
Martin Köbel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
T Cell Cytotoxicity

Sphere-derived Prostate Cancer Stem Cells Are Resistant to γδ T Cell Cytotoxicity

2020 ◽  
Vol 40 (10) ◽  
pp. 5481-5487
Author(s):  
MASATSUGU MIYASHITA ◽  
MAKO TOMOGANE ◽  
YUICHI NAKAMURA ◽  
TERUKI SHIMIZU ◽  
ATSUKO FUJIHARA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
T Cell ◽  
Cancer Stem Cells ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
Prostate Cancer Stem Cells ◽  
T Cell Cytotoxicity

scholarly journals TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Doaa Tawfik ◽  
Christopher Groth ◽  
Jan-Paul Gundlach ◽  
Matthias Peipp ◽  
Dieter Kabelitz ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Cells ◽  
Trail Receptor ◽  
Cell Cytotoxicity ◽  
Γδ T Cell ◽  
T Cell Cytotoxicity
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