scholarly journals β-Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor β expression

2006 ◽  
Vol 119 (9) ◽  
pp. 2084-2089 ◽  
Author(s):  
Fuzhi Lian ◽  
Kang-Quan Hu ◽  
Robert M. Russell ◽  
Xiang-Dong Wang
2004 ◽  
Vol 45 (3) ◽  
pp. 435 ◽  
Author(s):  
Yoon Soo Chang ◽  
Jae Ho Chung ◽  
Dong Hwan Shin ◽  
Kyung Young Chung ◽  
Young Sam Kim ◽  
...  

2020 ◽  
Vol 10 (5) ◽  
pp. 1367-1380 ◽  
Author(s):  
Mariana Magalhães ◽  
Joana Jorge ◽  
Ana Cristina Gonçalves ◽  
Ana Bela Sarmento-Ribeiro ◽  
Rui Carvalho ◽  
...  

2021 ◽  
Vol 11 (3) ◽  
pp. 453-457
Author(s):  
Caidi Zhang ◽  
Xinzhong Zou

To explore the effects of lncRNA MACC1-AS1 on the invasion and migration of non-small cell lung cancer (NSCLC), PCR was used to detect and compare lncRNA MACC1-AS1 expression in NSCLC cells to normal lung epithelial cells and assess the knockdown effect of lncRNA MACC1-AS1 in A549 and H1299 cell lines. The Transwell system was employed to compare the invasiveness of the lncRNA MACC1-AS1 knockdown cells to the control cells. The migratory ability of the lncRNA MACC1-AS1 knockdown cells was compared to the control cells via in vitro scratch assay. Western blot was used to detect the E-cadherin/N-cadherin expression. Balb/c mouse model was used to verify the metastasis ability in vivo between the control and lncRNA MACC1-AS1 knockdown groups. The level of lncRNA MACC1-AS1 was markedly higher in lung cancer cells than normal lung epithelial cells. The knockdown of lncRNA MACC1-AS1 reduced the invasiveness and migratory capacity of A549 and H1299 cells. Downregulating lncRNA MACC1-AS1 upregulated E-cadherin but down-regulated N-cadherin in A549 and H1299 cells. Besides, the silencing of lncRNA MACC1-AS1 reduced the A549 cells’ ability to metastasize in vivo. LncRNA MACC1-AS1 can enhance the invasiveness and migratory capability of NSCLC.


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