Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts

2006 ◽  
Vol 119 (4) ◽  
pp. 741-744 ◽  
Author(s):  
Steen Mollerup ◽  
Gisle Berge ◽  
Rita Bæra ◽  
Vidar Skaug ◽  
Alan Hewer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Sex Differences ◽  
Dna Adducts ◽  
Expression Of Genes ◽  
Bulky Dna Adducts

scholarly journals Relationship between TP53 tumour suppressor gene mutations and smoking-related bulky DNA adducts in a lung cancer study population from Hungary

Mutagenesis ◽  
2009 ◽  
Vol 24 (6) ◽  
pp. 475-480 ◽  
Author(s):  
Lívia Anna ◽  
Reetta Holmila ◽  
Katalin Kovács ◽  
Erika Győrffy ◽  
Zoltán Győri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Adducts ◽  
Gene Mutations ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Cancer Study ◽  
Study Population ◽  
Bulky Dna Adducts

scholarly journals Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study

2006 ◽  
Vol 118 (7) ◽  
pp. 1618-1622 ◽  
Author(s):  
Helle Bak ◽  
Herman Autrup ◽  
Birthe Lykke Thomsen ◽  
Anne Tjønneland ◽  
Kim Overvad ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Dna Adducts ◽  
Risk Indicator ◽  
Bulky Dna Adducts

scholarly journals Bulky DNA adducts as risk indicators of lung cancer in a Danish case-cohort study

2006 ◽  
Vol 120 (1) ◽  
pp. 212-213 ◽  
Author(s):  
Ole Raaschou-Nielsen ◽  
Birthe L. Thomsen ◽  
Kim Overvad ◽  
Anne Tjønneland ◽  
Ulla Vogel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Dna Adducts ◽  
Risk Indicators ◽  
Bulky Dna Adducts

Bulky DNA Adducts, Tobacco Smoking, Genetic Susceptibility, and Lung Cancer Risk

2017 ◽  
pp. 231-277 ◽  
Author(s):  
Armelle Munnia ◽  
Roger W. Giese ◽  
Simone Polvani ◽  
Andrea Galli ◽  
Filippo Cellai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Genetic Susceptibility ◽  
Dna Adducts ◽  
Tobacco Smoking ◽  
Lung Cancer Risk ◽  
Bulky Dna Adducts

Role of sex hormones in lung cancer

2021 ◽  
pp. 153537022110196
Author(s):  
Nathalie Fuentes ◽  
Miguel Silva Rodriguez ◽  
Patricia Silveyra
Keyword(s):  
Lung Cancer ◽  
Sex Differences ◽  
Sex Hormones ◽  
Hormone Receptors ◽  
Occupational Exposures ◽  
Lung Carcinogenesis ◽  
Male And Female ◽  
Female Sex ◽  
Incidence And Mortality ◽  
Cancer Rates

Lung cancer represents the world’s leading cause of cancer deaths. Sex differences in the incidence and mortality rates for various types of lung cancers have been identified, but the biological and endocrine mechanisms implicated in these disparities have not yet been determined. While some cancers such as lung adenocarcinoma are more commonly found among women than men, others like squamous cell carcinoma display the opposite pattern or show no sex differences. Associations of tobacco product use rates, susceptibility to carcinogens, occupational exposures, and indoor and outdoor air pollution have also been linked to differential rates of lung cancer occurrence and mortality between sexes. While roles for sex hormones in other types of cancers affecting women or men have been identified and described, little is known about the influence of sex hormones in lung cancer. One potential mechanism identified to date is the synergism between estrogen and some tobacco compounds, and oncogene mutations, in inducing the expression of metabolic enzymes, leading to enhanced formation of reactive oxygen species and DNA adducts, and subsequent lung carcinogenesis. In this review, we present the literature available regarding sex differences in cancer rates, associations of male and female sex hormones with lung cancer, the influence of exogenous hormone therapy in women, and potential mechanisms mediated by male and female sex hormone receptors in lung carcinogenesis. The influence of biological sex on lung disease has recently been established, thus new research incorporating this variable will shed light on the mechanisms behind the observed disparities in lung cancer rates, and potentially lead to the development of new therapeutics to treat this devastating disease.

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