scholarly journals Iron and colorectal cancer risk in the α-tocopherol, β-carotene cancer prevention study

2006 ◽  
Vol 118 (12) ◽  
pp. 3147-3152 ◽  
Author(s):  
Amanda J. Cross ◽  
Marc J. Gunter ◽  
Richard J. Wood ◽  
Pirjo Pietinen ◽  
Philip R. Taylor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Colorectal Cancer Risk ◽  
Prevention Study ◽  
Β Carotene

scholarly journals Pre-Diagnostic Circulating Metabolites and Colorectal Cancer Risk in the Cancer Prevention Study-II Nutrition Cohort

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 156
Author(s):  
Marjorie L. McCullough ◽  
Rebecca A. Hodge ◽  
Peter T. Campbell ◽  
Victoria L. Stevens ◽  
Ying Wang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Conditional Logistic Regression ◽  
Colorectal Cancer Risk ◽  
Prevention Study ◽  
Blood Draw ◽  
Logistic Regression Models ◽  
Nested Case Control ◽  
Control Study

Untargeted metabolomic studies have identified potential biomarkers of colorectal cancer risk, but evidence is still limited and broadly inconsistent. Among 39,239 Cancer Prevention Study II Nutrition cohort participants who provided a blood sample between 1998–2001, 517 newly diagnosed colorectal cancers were identified through 30 June 2015. In this nested case–control study, controls were matched 1:1 to cases on age, sex, race and date of blood draw. Mass spectroscopy-based metabolomic analyses of pre-diagnostic plasma identified 886 named metabolites, after quality control exclusions. Conditional logistic regression models estimated multivariable-adjusted odds ratios (OR) and 95% confidence intervals (CI) for 1 standard deviation (SD) increase in each metabolite with risk of colorectal cancer. Six metabolites were associated with colorectal cancer risk at a false discovery rate < 0.20. These metabolites were of several classes, including cofactors and vitamins, nucleotides, xenobiotics, lipids and amino acids. Five metabolites (guanidinoacetate, 2’-O-methylcytidine, vanillylmandelate, bilirubin (E,E) and N-palmitoylglycine) were positively associated (OR per 1 SD = 1.29 to 1.32), and one (3-methylxanthine) was inversely associated with CRC risk (OR = 0.79, 95% CI, 0.69–0.89). We did not replicate findings from two earlier prospective studies of 250 cases each after adjusting for multiple comparisons. Large pooled prospective analyses are warranted to confirm or refute these findings and to discover and replicate metabolites associated with colorectal cancer risk.

scholarly journals Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II)

2012 ◽  
Vol 10 (3) ◽  
pp. 175 ◽  
Author(s):  
Jaeseong Jo ◽  
Chung Mo Nam ◽  
Jae Woong Sull ◽  
Ji Eun Yun ◽  
Sang Yeun Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Colorectal Cancer Risk ◽  
Prevention Study

scholarly journals Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study

2017 ◽  
Vol 141 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Dora Romaguera ◽  
Esther Gracia-Lavedan ◽  
Amaia Molinuevo ◽  
Jordi de Batlle ◽  
Michelle Mendez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Prevention Guidelines ◽  
Control Study

scholarly journals Familial colorectal cancer risk assessment needs improvement for more effective cancer prevention in relatives

2013 ◽  
Vol 15 (4) ◽  
pp. e175-e185 ◽  
Author(s):  
N. Dekker ◽  
R. P. M. G. Hermens ◽  
F. M. Nagengast ◽  
W. A. G. van Zelst-Stams ◽  
N. Hoogerbrugge ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Assessment ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Colorectal Cancer Risk ◽  
Cancer Risk Assessment ◽  
Familial Colorectal Cancer

Adherence to cancer prevention guideline and colorectal cancer risk in the hexa study

2018 ◽  
Vol 37 ◽  
pp. S311
Author(s):  
J. Lee ◽  
A. Shin ◽  
S. Cho ◽  
J.-Y. Choi ◽  
D. Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Colorectal Cancer Risk ◽  
Prevention Guideline
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