scholarly journals Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers

2006 ◽  
Vol 118 (10) ◽  
pp. 2509-2513 ◽  
Author(s):  
Barbara Jung ◽  
E. Julieta Smith ◽  
Ryan T. Doctolero ◽  
Pascal Gervaz ◽  
Julio C. Alonso ◽  
...  
Keyword(s):  
Target Gene ◽  
Gene Mutations ◽  
Colon Cancers

Genomic instability and target gene mutations in colon cancers with different degrees of allelic shifts

2000 ◽  
Vol 27 (4) ◽  
pp. 424-429 ◽  
Author(s):  
Antonio Percesepe ◽  
Monica Pedroni ◽  
Elisa Sala ◽  
Mirco Menigatti ◽  
Francesca Borghi ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Target Gene ◽  
Gene Mutations ◽  
Colon Cancers

scholarly journals The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers

2021 ◽  
Vol 22 (12) ◽  
pp. 3839-3846
Author(s):  
Yesim Ozdemir ◽  
Murat Cag ◽  
Emel Colak ◽  
Nuriye Coskun ◽  
Neslihan Basgoz ◽  
...  
Keyword(s):  
Overall Survival ◽  
Gene Mutations ◽  
Colon Cancers

scholarly journals Role of Active Efflux in Association with Target Gene Mutations in Fluoroquinolone Resistance in Clinical Isolates of Vibrio cholerae

2002 ◽  
Vol 46 (8) ◽  
pp. 2676-2678 ◽  
Author(s):  
Somesh Baranwal ◽  
Keya Dey ◽  
T. Ramamurthy ◽  
G. Balakrish Nair ◽  
Manikuntala Kundu
Keyword(s):  
Vibrio Cholerae ◽  
Target Gene ◽  
Target Genes ◽  
Gene Mutations ◽  
Proton Motive Force ◽  
Quinolone Resistance ◽  
Clinical Isolates ◽  
Fluoroquinolone Resistance ◽  
Active Efflux

ABSTRACT Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.

Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer

2001 ◽  
Vol 194 (3) ◽  
pp. 334-340 ◽  
Author(s):  
Shin-ya Ogata ◽  
Gen Tamura ◽  
Yasushi Endoh ◽  
Ken Sakata ◽  
Kiyonari Ohmura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Target Gene ◽  
Gene Mutations ◽  
Early Stages ◽  
Multiple Gastric Cancer

scholarly journals Brief Research Report Regional Difference in TRAF2 and TRAF3 Gene Mutations in Colon Cancers

2021 ◽  
Vol 27 ◽  
Author(s):  
Seong Won Moon ◽  
Hyun Ji Son ◽  
Eun Ji Choi ◽  
Nam Jin Yoo ◽  
Sug Hyung Lee
Keyword(s):  
Regional Difference ◽  
Tumor Necrosis Factor Receptor ◽  
Gene Mutations ◽  
Suppressor Gene ◽  
Research Report ◽  
Colon Cells ◽  
Frameshift Mutations ◽  
Colon Cancers ◽  
And Function ◽  
Necrosis Factor

TRAF2 and TRAF3 genes of tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family are involved in diverse cell signaling, and function as both tumor suppressor gene and oncogene. Alterations of TRAF2 and TRAF3 in colon cancer (CC) along with their regional difference and microsatellite instability (MSI) are largely unknown. In the present study, we analyzed TRAF2 and TRAF3 frameshift mutations in 168 sporadic CCs (100 high MSI (MSI-H) and 68 microsatellite-stable (MSS) CCs). We identified TRAF2 and TRAF3 frameshift mutations in 4 (4%) and 3 CCs (3%) with MSI-H, respectively, but none in 68 cases of MSS CCs. Of the 168 CCs, we analyzed the mutations in multi-regions for 39 CCs (16 MSI-H and 23 MSS CCs), and discovered that 12.5% (2/16) and 6.3% (1/16) of MSI-H CCs exhibited regional difference in TRAF2 and TRAF3 mutations, respectively. In the multi-region samples of 23 MSS CCs, neither TRAF2 nor TRAF3 frameshift mutation was found. In 40% of CCs, both TRAF2 and TRAF3 expressions were increased compared to normal colon cells. Our data indicate that TRAF2 and TRAF3 frameshift mutations and their regional difference as well as altered expressions are present in MSI-H CCs, which could contribute to MSI-H cancer development.

Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer

The Prostate ◽  
2006 ◽  
Vol 66 (6) ◽  
pp. 660-666 ◽  
Author(s):  
Xiaodong Sun ◽  
Ceshi Chen ◽  
Robert L. Vessella ◽  
Jin-Tang Dong
Keyword(s):  
Prostate Cancer ◽  
Microsatellite Instability ◽  
Mismatch Repair ◽  
Cell Lines ◽  
Target Gene ◽  
Gene Mutations

scholarly journals Comparison of Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Elizabethkingia meningoseptica and Elizabethkingia anophelis Isolated in Taiwan

2018 ◽  
Vol 7 (12) ◽  
pp. 538 ◽  
Author(s):  
Jiun-Nong Lin ◽  
Chung-Hsu Lai ◽  
Chih-Hui Yang ◽  
Yi-Han Huang
Keyword(s):  
Ribosomal Rna ◽  
Target Gene ◽  
Target Genes ◽  
Clinical Manifestations ◽  
Gene Mutations ◽  
Clinical Microbiology Laboratory ◽  
Elizabethkingia Meningoseptica ◽  
Major Pathogens ◽  
Susceptibility Patterns ◽  
Multiple Antibiotics

Elizabethkingia meningoseptica and Elizabethkingia anophelis are two major pathogens in the genus Elizabethkingia. Studies have revealed that Elizabethkingia anophelis is frequently misidentified as E. meningoseptica. Therefore, our aim was to explore the clinical and molecular differences between these two species. The database of a clinical microbiology laboratory in a university-affiliated hospital of Taiwan was searched to identify patients with Elizabethkingia infections between January 2005 and June 2018. Species were reidentified using 16S ribosomal RNA gene sequencing. Twenty E. meningoseptica and 72 E. anophelis samples were collected from consecutive patients. E. meningoseptica was significantly more frequently isolated from the cerebrospinal fluid than was E. anophelis. The most susceptible antibiotic for all Elizabethkingia isolates was minocycline (91.3%), followed by levofloxacin (52.2%), tigecycline (23.9%), and piperacillin tazobactam (23.9%). Compared with E. anophelis, E. meningoseptica was significantly less susceptible to piperacillin tazobactam, minocycline, and levofloxacin. Regarding nonsynonymous substitutions in the quinolone-resistance determining regions of DNA gyrase, six sites were recognized in E. meningoseptica and one site was recognized in E. anophelis. E. meningoseptica had a significantly higher rate of fluoroquinolone target gene mutations than did E. anophelis. Because of less susceptibility to multiple antibiotics than E. anophelis, empirical antimicrobial therapy of E. meningoseptica should be more rigorous.

Sign in / Sign up

Export Citation Format

Share Document