Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin γ-2 chain is an early coordinated event in incipient oral squamous cell carcinoma

2006 ◽  
Vol 118 (12) ◽  
pp. 2948-2956 ◽  
Author(s):  
Pia Lindberg ◽  
Åke Larsson ◽  
Boye Schnack Nielsen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Plasminogen Activator ◽  
Squamous Cell ◽  
Plasminogen Activator Inhibitor ◽  
Urokinase Receptor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Activator Inhibitor

Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma

Head & Neck ◽  
2007 ◽  
Vol 29 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Luciënne Speleman ◽  
Jeroen D. F. Kerrebijn ◽  
Maxime P. Look ◽  
Cees A. Meeuwis ◽  
John A. Foekens ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Plasminogen Activator ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Plasminogen Activator Inhibitor ◽  
Neck Squamous Cell Carcinoma ◽  
Plasminogen Activator Inhibitor 1 ◽  
Activator Inhibitor

scholarly journals Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production

2021 ◽  
Vol 22 (17) ◽  
pp. 9475
Author(s):  
Kazuki Kai ◽  
Masafumi Moriyama ◽  
A. S. M. Rafiul Haque ◽  
Taichi Hattori ◽  
Akira Chinju ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Tumor Associated Macrophages ◽  
High Concentrations ◽  
Pai 1

Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment and differentiation of TAMs, but the detailed mechanisms have not been clarified. We thus examined the influence of cancer cells on the differentiation of monocytes to TAM subsets, including CD163+, CD204+, and CD206+ cells, in oral squamous cell carcinoma (OSCC) using immunohistochemistry, flow cytometry, and a cytokine array. Furthermore, we investigated the effect of OSCC cells (HSC-2, SQUU-A, and SQUU-B cells) on the differentiation of purified CD14+ cells to TAM subsets. The localization patterns of CD163+, CD204+, and CD206+ in OSCC sections were quite different. The expression of CD206 on CD14+ cells was significantly increased after the co-culture with OSCC cell lines, while the expressions of CD163 and CD204 on CD14+ cells showed no change. High concentrations of plasminogen activator inhibitor-1 (PAI-1) and interleukin-8 (IL-8) were detected in the conditioned medium of OSCC cell lines. PAI-1 and IL-8 stimulated CD14+ cells to express CD206. Moreover, there were positive correlations among the numbers of CD206+, PAI-1+, and IL-8+ cells in OSCC sections. These results suggest that PAI-1 and IL-8 produced by OSCC contribute to the differentiation of monocytes to CD206+ TAMs.

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