scholarly journals Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas

2005 ◽  
Vol 118 (5) ◽  
pp. 1154-1158 ◽  
Author(s):  
Flávio J. Pimenta ◽  
Dawidson A. Gomes ◽  
Paolla F. Perdigão ◽  
Alvimar A. Barbosa ◽  
Marco A. Romano-Silva ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

Characterization of a Novel Tumor-Suppressor Gene PLCδ1 at 3p22 in Esophageal Squamous Cell Carcinoma

2007 ◽  
Vol 67 (22) ◽  
pp. 10720-10726 ◽  
Author(s):  
Li Fu ◽  
Yan-Ru Qin ◽  
Dan Xie ◽  
Liang Hu ◽  
Dora L. Kwong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene

Analysis of the equine tumor suppressor gene p53 in the normal horse and in eight cutaneous squamous cell carcinomas

1996 ◽  
Vol 107 (1) ◽  
pp. 125-130 ◽  
Author(s):  
Karen A. Pazzi ◽  
Susan A. Kraegel ◽  
Stephen M. Griffey ◽  
Alain P. Theon ◽  
Bruce R. Madewell
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Tumor Suppressor Gene P53

Analysis of p53 Tumor Suppressor Gene, H-ras Protooncogene and Proliferating Cell Nuclear Antigen (PCNA) in Squamous Cell Carcinomas of HRA/Skh Mice Following Exposure to 8-Methoxypsoralen (8-MOP) and UVA Radiation (PUVA Therapy)

2005 ◽  
Vol 33 (2) ◽  
pp. 292-299 ◽  
Author(s):  
Luca Lambertini ◽  
Kezia Surin ◽  
Thai-Vu T. Ton ◽  
Natasha Clayton ◽  
June K. Dunnick ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Protein Expression ◽  
Tumor Suppressor Gene ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Puva Therapy ◽  
P53 Tumor Suppressor ◽  
Ras Genes ◽  
P53 Tumor Suppressor Gene

Treatment with 8-methoxypsoralen (8-MOP) and ultraviolet radiation (primarily UVA), called PUVA therapy, has been used to treat different chronic skin diseases but led to a significant increased risk for skin cancer. The National Toxicology Program (NTP) performed a study in mice treated with PUVA that showed a significant increase in squamous cell carcinomas of the skin. In the present study, we evaluated the protein expression of p53 and PCNA and DNA mutations of p53 and H-ras genes in both hyperplastic and neoplastic squamous cell lesions from the NTP study. By immunohistochemical staining, protein expression of both p53 and PCNA was detected in 3/16 (19%) of hyperplastic lesions and 14/17 (82%) of SCCs in groups treated with both 8-MOP and UVA. The mutation frequency of p53 in SCCs from mice administered 8-MOP plus UVA was 15/17 (88%) with a predominant distribution of mutations in exon 6 (14/15 – 93%). No H-ras mutations were detected in the hyperplastic lesions/tumors. The mutagenic effect of PUVA on the p53 tumor suppressor gene may lead to a conformational modification and inactivation of the p53 protein, which are considered critical steps in PUVA-induced skin carcinogenesis. The p53 mutational frequency and patterns from our study were different from those reported in human PUVA-type tumors.

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