scholarly journals FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth

2005 ◽  
Vol 118 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Hany Kayed ◽  
Jörg Kleeff ◽  
Armin Kolb ◽  
Knut Ketterer ◽  
Shereen Keleg ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Ductal Adenocarcinoma ◽  
Cancer Cell Growth

scholarly journals Inhibition of Sphingosine-1-Phosphate signaling in pancreatic ductal adenocarcinoma leads to downregulation of growth and invasion

2020 ◽  
Author(s):  
Brenna A. Rheinheimer ◽  
Alex Cardenas ◽  
Luis Camacho ◽  
Evan S. Ong ◽  
Tun Jie ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Leading Edge ◽  
Cancer Cell Lines ◽  
Ductal Adenocarcinoma ◽  
Sphingosine 1 Phosphate

AbstractBackgroundDeregulated phosphorylation of sphingosine by the sphingosine kinases and signaling through the EDG family of receptors enhances growth and survival in many cell types. Therefore, we sought to elucidate the effect of alterations in the ceramide/sphingosine/S1P rheostat on driving human pancreatic ductal adenocarcinoma towards a malignant phenotype.MethodsPancreatic cancer cell lines were treated with exogenous S1P, FTY720, and siRNA to Sphk1. Migration was evaluated by wound healing assays, cell growth by MTT assays, and invasion by tumorsphere assays. Expression of S1PR1, S1PR3, Sphk1, and Sphk2 were measured by quantitative PCR, western blot, and immunohistochemistry.ResultsS1PR1, S1PR3, and Sphk2 were overexpressed in all pancreatic cancer cell lines. Sphk1 translocated from the cytoplasm to the nucleus in cells located at the leading edge of cell clusters. Exogenous S1P increased cell migration while treatment with FTY720 and Sphk1 siRNA decreased cell growth and invasion.ConclusionsOur results suggest that increased S1PR1 expression may be an early event in pancreatic cancer pathogenesis. Additionally, altered Sphk1 localization may provide a mechanism through which pancreatic ductal adenocarcinoma cells at the leading edge invade into the surrounding matrix. Finally, inhibition of sphingosine-1-phosphate signaling may provide a novel therapeutic target for patients with metastatic disease.

scholarly journals Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression

2017 ◽  
Vol Volume 11 ◽  
pp. 2481-2491 ◽  
Author(s):  
Yuejun Li ◽  
Lili Gong ◽  
Ruili Qi ◽  
Qian Sun ◽  
Xinxin Xia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Correction: DeltaNp63alpha-Mediated Induction of Epidermal Growth Factor Receptor Promotes Pancreatic Cancer Cell Growth and Chemoresistance

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192927
Author(s):  
Alexey V. Danilov ◽  
Divas Neupane ◽  
Archana Sidalaghatta Nagaraja ◽  
Elena V. Feofanova ◽  
Leigh Ann Humphries ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Growth Factor Receptor ◽  
Cancer Cell Growth ◽  
Epidermal Growth

scholarly journals Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

Oncotarget ◽  
2018 ◽  
Vol 9 (47) ◽  
pp. 28434-28444 ◽  
Author(s):  
Shuhei Shinoda ◽  
Seiji Kaino ◽  
Shogo Amano ◽  
Hirofumi Harima ◽  
Toshihiko Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Iron Chelator ◽  
Oral Iron ◽  
Cancer Cell Growth ◽  
Oral Iron Chelator

scholarly journals pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e15455 ◽  
Author(s):  
Timothy K. Williams ◽  
Christina L. Costantino ◽  
Nikolai A. Bildzukewicz ◽  
Nathan G. Richards ◽  
David W. Rittenhouse ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Gemcitabine Resistance

S1273 Stimulation of Pancreatic Cancer Cell Growth By Glucose-Dependent Insulinotropic Polypeptide (GIP)

2009 ◽  
Vol 136 (5) ◽  
pp. A-227
Author(s):  
Joseph D. Feuerstein ◽  
Daniel Prabakaran ◽  
Jennifer Ku ◽  
Priti Bijpuria ◽  
M. Michael Wolfe
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Stimulation Of
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