scholarly journals Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression

2005 ◽  
Vol 117 (6) ◽  
pp. 905-912 ◽  
Author(s):  
Xiu-Mei Cai ◽  
Bei-Bei Tao ◽  
Li-Ying Wang ◽  
Yu-Long Liang ◽  
Jia-Wei Jin ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Phosphatase Activity ◽  
Protein Phosphatase ◽  
Growth Factor Receptor ◽  
Glioma Cells ◽  
Type Iii ◽  
Epidermal Growth ◽  
Mutation Type

scholarly journals Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase

1988 ◽  
Vol 256 (3) ◽  
pp. 1029-1034 ◽  
Author(s):  
J Goris ◽  
C J Pallen ◽  
P J Parker ◽  
J Hermann ◽  
M D Waterfield ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Phosphatase Activity ◽  
Growth Factor Receptor ◽  
Xenopus Laevis Oocytes ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Epidermal Growth ◽  
Autophosphorylation Site

By use of the autophosphorylated epidermal-growth-factor receptor and the synthetic peptide RRLIE-DAEY(P)AARG, representing an autophosphorylation site of the transforming protein of Rous-sarcoma virus, it is demonstrated that the phosphotyrosyl phosphatase activity of the polycation-stimulated phosphatases is substantially increased by an enzyme-directed effect of ATP or PPi. Concomitant with this increase in phosphotyrosyl phosphatase activity, the phosphorylase phosphatase activity is decreased, thus dramatically changing the substrate specificity of these enzymes. The dephosphorylation of four different phosphotyrosyl sites of the epidermal-growth-factor receptor is neither consecutive nor at random, but a preferred dephosphorylation of the P1 site over the P3 greater than P2 greater than P4 sites is observed. This phosphatase activity represents a substantial fraction of the total phosphotyrosyl phosphatase activity in the post-mitochondrial supernatant of Xenopus laevis oocytes.

CAR-T cell immunotherapies targeting type III variant epidermal growth factor receptor, a glioma-associated antigen.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e14022-e14022
Author(s):  
Elodie Bole-Richard ◽  
Jean-Marie Certoux ◽  
Jean-Rene Pallandre ◽  
Idir Idirene ◽  
Christophe Borg ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
T Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Type Iii ◽  
Car T Cell ◽  
Car T ◽  
Epidermal Growth
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