scholarly journals Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway

2005 ◽  
Vol 117 (3) ◽  
pp. 340-348 ◽  
Author(s):  
Min Wu ◽  
Kevin A. Harvey ◽  
Nargiz Ruzmetov ◽  
Zachary R. Welch ◽  
Laura Sech ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Growth ◽  
Omega 3 ◽  
Neutral Sphingomyelinase ◽  
Breast Cancer Growth

scholarly journals Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells

2009 ◽  
Vol 31 (3) ◽  
pp. 489-495 ◽  
Author(s):  
Manjari Dimri ◽  
Prashant V. Bommi ◽  
Anagh A. Sahasrabuddhe ◽  
Janardan D. Khandekar ◽  
Goberdhan P. Dimri
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Omega 3

Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells

2017 ◽  
Vol 41 (8) ◽  
pp. 890-897 ◽  
Author(s):  
Jing Yang ◽  
Shenglong Zhu ◽  
Guangxiao Lin ◽  
Ci Song ◽  
Zhao He
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Vitamin D ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Omega 3 ◽  
Induced Apoptosis

Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors

2019 ◽  
Vol 10 (7) ◽  
pp. 751-758 ◽  
Author(s):  
A. Horigome ◽  
R. Okubo ◽  
K. Hamazaki ◽  
T. Kinoshita ◽  
N. Katsumata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Cross Sectional Study ◽  
Omega 3 ◽  
Cross Sectional ◽  
History Of

Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients demonstrated to have health benefits, such as decreasing the risk of coronary heart disease, improving parameters associated with metabolic syndrome, and decreasing anxiety symptoms and depression risk. Previous intervention studies indicated the association between blood or tissue PUFA levels and the gut microbiota; however, the details remain incompletely elucidated. We conducted a cross-sectional study to examine the association between PUFAs and the gut microbiota among breast cancer survivors. Adults who had been diagnosed with invasive breast cancer more than one year ago and were not currently undergoing chemotherapy were enrolled. Capillary blood and faecal samples were obtained to assess the blood PUFA levels and gut microbiota compositions. The mean age (n=124) was 58.7 years, and 46% of the participants had a history of chemotherapy. Multiple regression analysis controlling for possible confounders indicated that an increased relative abundance of Actinobacteria was significantly associated with increased levels of docosahexaenoic acid (DHA, beta=0.304, q<0.01). At the genus level, the abundance of Bifidobacterium was positively associated with the level of DHA (beta=0.307, q<0.01). No significant association between omega-6 PUFAs and the relative abundances of gut microbiota members was observed. In addition, analyses stratified by the history of chemotherapy indicated significant associations of PUFA levels with the abundance of some bacterial taxa, including the phylum Actinobacteria (DHA, beta=0.365, q<0.01) and Bacteroidetes (EPA, beta=-0.339, q<0.01) and the genus Bifidobacterium (DHA, beta=0.368, q<0.01) only among participants without a history of chemotherapy. These findings provide the first evidence of positive associations between the abundances of Bifidobacterium among the gut microbiota and the levels of omega-3 PUFAs in the blood. Further studies are required to gain additional insight into these associations in healthy subjects as well as into the causality of the relationship.

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