scholarly journals Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status

2005 ◽  
Vol 117 (5) ◽  
pp. 730-737 ◽  
Author(s):  
Wen G. Jiang ◽  
Gareth Watkins ◽  
Anthony Douglas-Jones ◽  
Kefah Mokbel ◽  
Robert E Mansel ◽  
...  
2006 ◽  
Vol 13 (2) ◽  
pp. 327-334 ◽  
Author(s):  
Leigh C Murphy ◽  
Peter H Watson

The role of oestrogen receptor (ER) β in human breast cancer remains unclear. However, it is now apparent that when considering ER β in human breast cancer it is important to recognise two ER β expressing groups, one in which ER β is co-expressed with ER α and the other where ERβ is expressed alone. Emerging data support different functions between ER β when it is expressed alone and when it is co-expressed with ER α. With regard to the latter group (ER α +/ER β +), there are now 9 out of 10 retrospective clinical outcome studies published, that support the hypothesis that increased expression of ER β is associated with increased likelihood of response to endocrine therapy. The data strongly support undertaking prospective studies to determine if the addition of ERβ to ER α is clinically beneficial and whether to include both ER β and ER α when establishing clinically relevant cut-offs for defining ER status.


BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Wen G Jiang ◽  
Gareth Watkins ◽  
Anthony Douglas-Jones ◽  
Lars Holmgren ◽  
Robert E Mansel

2014 ◽  
Vol 148 (1) ◽  
pp. 41-59 ◽  
Author(s):  
Katherine Drews-Elger ◽  
Elizabeth Iorns ◽  
Alexandra Dias ◽  
Philip Miller ◽  
Toby M. Ward ◽  
...  

2012 ◽  
Vol 189 (10) ◽  
pp. 5029-5036 ◽  
Author(s):  
Chunling Ma ◽  
Qunyuan Zhang ◽  
Jian Ye ◽  
Fang Wang ◽  
Yanping Zhang ◽  
...  

2008 ◽  
Vol 7 (1) ◽  
pp. 71 ◽  
Author(s):  
Wen G Jiang ◽  
Tracey A Martin ◽  
Jo M Lewis-Russell ◽  
Anthony Douglas-Jones ◽  
Lin Ye ◽  
...  

1997 ◽  
Vol 25 (2) ◽  
pp. 356S-356S ◽  
Author(s):  
JOHN BOLODEOKU ◽  
KAZUHIRO YOSHIDA ◽  
TAKASHI SUGINO ◽  
MICHAEL CHURCHMAN ◽  
ANTHONY WOODMAN ◽  
...  

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