scholarly journals Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice

2004 ◽  
Vol 111 (4) ◽  
pp. 475-479 ◽  
Author(s):  
Vladimir N. Anisimov ◽  
Dmitri A. Baturin ◽  
Irina G. Popovich ◽  
Mark A. Zabezhinski ◽  
Kenneth G. Manton ◽  
...  
Keyword(s):  
Life Span ◽  
Light At Night ◽  
Cba Mice ◽  
Spontaneous Carcinogenesis

scholarly journals Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

2008 ◽  
Vol 2008 ◽  
pp. 1-11 ◽  
Author(s):  
Tatiana S. Piskunova ◽  
Maria N. Yurova ◽  
Anton I. Ovsyannikov ◽  
Anna V. Semenchenko ◽  
Mark A. Zabezhinski ◽  
...  
Keyword(s):  
Dna Repair ◽  
Life Span ◽  
Soft Tissues ◽  
Telomere Maintenance ◽  
Biological Aging ◽  
Spontaneous Tumors ◽  
Uterine Tumors ◽  
Dna Repair Gene ◽  
Spontaneous Carcinogenesis ◽  
Parp 1

Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP- mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP- mice. The incidence of spontaneous tumors in both PARP- and PARP- groups is similar; however, malignant tumors including uterine tumors, lung adenocarcinomas and hepatocellular carcinomas, develop at a significantly higher frequency in PARP- mice than PARP- mice (72% and 49%, resp.; .05). In addition, spontaneous tumors appear earlier in PARP- mice compared to the wild type group. Histopathological studies revealed a wide spectrum of tumors in uterus, ovaries, liver, lungs, mammary gland, soft tissues, and lymphoid organs in both groups of the mice. These results demonstrate that inactivation of DNA repair gene PARP-1 in mice leads to acceleration of aging, shortened life span, and increased spontaneous carcinogenesis.

scholarly journals Melatonin Increases Both Life Span and Tumor Incidence in Female CBA Mice

2001 ◽  
Vol 56 (7) ◽  
pp. B311-B323 ◽  
Author(s):  
V. N. Anisimov ◽  
N. Y. Zavarzina ◽  
M. A. Zabezhinski ◽  
I. G. Popovich ◽  
O. A. Zimina ◽  
...  
Keyword(s):  
Life Span ◽  
Tumor Incidence ◽  
Cba Mice

Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice

2015 ◽  
Vol 17 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Andrey V. Panchenko ◽  
Irina G. Popovich ◽  
Alexandr P. Trashkov ◽  
Peter A. Egormin ◽  
Maria N. Yurova ◽  
...  
Keyword(s):  
Life Span ◽  
Wild Type ◽  
Female Mice ◽  
Biomarkers Of Aging ◽  
In The Wild ◽  
Her 2 ◽  
Spontaneous Carcinogenesis

Continuum of Care Following Sports-Related Concussion

2020 ◽  
Vol 29 (3) ◽  
pp. 1389-1403
Author(s):  
Jessica Brown ◽  
Kelly Knollman-Porter
Keyword(s):  
Young Adults ◽  
Life Span ◽  
Sports Injuries ◽  
Continuum Of Care ◽  
Medical Professional ◽  
Structured Interviews ◽  
Youth Athletes ◽  
Speech Language Pathologist ◽  
History Of ◽  
Injury Reporting

Purpose Although guidelines have changed regarding federally mandated concussion practices since their inception, little is known regarding the implementation of such guidelines and the resultant continuum of care for youth athletes participating in recreational or organized sports who incur concussions. Furthermore, data regarding the role of speech-language pathologists in the historic postconcussion care are lacking. Therefore, the purpose of this retrospective study was to investigate the experiences of young adults with history of sports-related concussion as it related to injury reporting and received follow-up care. Method Participants included 13 young adults with history of at least one sports-related concussion across their life span. We implemented a mixed-methods design to collect both quantitative and qualitative information through structured interviews. Participants reported experiencing 42 concussions across the life span—26 subsequent to sports injuries. Results Twenty-three concussions were reported to a parent or medical professional, 14 resulted in a formal diagnosis, and participants received initial medical care for only 10 of the incidents and treatment or services on only two occasions. Participants reported concussions to an athletic trainer least frequently and to parents most frequently. Participants commented that previous experience with concussion reduced the need for seeking treatment or that they were unaware treatments or supports existed postconcussion. Only one concussion incident resulted in the care from a speech-language pathologist. Conclusion The results of the study reported herein shed light on the fidelity of sports-related concussion care management across time. Subsequently, we suggest guidelines related to continuum of care from injury to individualized therapy.

Tumorigenesis in High-Dose Total Body Irradiated Rhesus Monkeys--A Life Span Study

2003 ◽  
Vol 31 (2) ◽  
pp. 209-213 ◽  
Author(s):  
Carel F. Hollander ◽  
Chris Zurcher ◽  
Johan J. Broerse
Keyword(s):  
Life Span ◽  
Rhesus Monkeys ◽  
High Dose ◽  
Life Span Study ◽  
Total Body

Conflict Monitoring Across the Life Span

2014 ◽  
Vol 28 (3) ◽  
pp. 124-135 ◽  
Author(s):  
Daniela Czernochowski
Keyword(s):  
Older Adults ◽  
Life Span ◽  
Age Groups ◽  
Conflict Detection ◽  
Response Conflict ◽  
Conflict Monitoring ◽  
Subsequent Performance ◽  
Additional Control ◽  
Performance Response ◽  
Conflict Detection And Resolution

Errors can play a major role for optimizing subsequent performance: Response conflict associated with (near) errors signals the need to recruit additional control resources to minimize future conflict. However, so far it remains open whether children and older adults also adjust their performance as a function of preceding response conflict. To examine the life span development of conflict detection and resolution, response conflict was elicited during a task-switching paradigm. Electrophysiological correlates of conflict detection for correct and incorrect responses and behavioral indices of post-error adjustments were assessed while participants in four age groups were asked to focus on either speed or accuracy. Despite difficulties in resolving response conflict, the ability to detect response conflict as indexed by the Ne/ERN component was expected to mature early and be preserved in older adults. As predicted, reliable Ne/ERN peaks were detected across age groups. However, only for adults Ne/ERN amplitudes associated with errors were larger compared to Nc/CRN amplitudes for correct trials under accuracy instructions, suggesting an ongoing maturation in the ability to differentiate levels of response conflict. Behavioral interference costs were considerable in both children and older adults. Performance for children and older adults deteriorated rather than improved following errors, in line with intact conflict detection, but impaired conflict resolution. Thus, participants in all age groups were able to detect response conflict, but only young adults successfully avoided subsequent conflict by up-regulating control.

Examining Relationships Across the Life Span

1997 ◽  
Vol 42 (2) ◽  
pp. 116-117
Author(s):  
Susan M. Profilet
Keyword(s):  
Life Span
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