scholarly journals Expression of protein kinase C ?1 confers resistance to TNF?- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

2001 ◽  
Vol 93 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Patrizia Cesaro ◽  
Elisabetta Raiteri ◽  
Marina D�moz ◽  
Roberta Castino ◽  
Francesco M. Baccino ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Kinase C ◽  
Induced Apoptosis ◽  
Ht 29

Apple Polyphenols Affect Protein Kinase C Activity and the Onset of Apoptosis in Human Colon Carcinoma Cells

2007 ◽  
Vol 55 (13) ◽  
pp. 4999-5006 ◽  
Author(s):  
Melanie Kern ◽  
Gudrun Pahlke ◽  
Kamal Kumar Balavenkatraman ◽  
Frank D. Böhmer ◽  
Doris Marko
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Kinase C ◽  
Human Colon Carcinoma ◽  
Protein Kinase C Activity

Protein kinase C and casein kinase II activities in two human colon carcinoma cell lines, HT-29 and CaCo-2: Possible correlation with differentiation

1990 ◽  
Vol 10 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Ewa Rydell ◽  
Karl-Eric Magnusson ◽  
Anita Sjö ◽  
Krister Axelsson
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Colon Carcinoma ◽  
Carcinoma Cell ◽  
Human Colon ◽  
Human Colon Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Kinase C ◽  
Human Colon Carcinoma ◽  
Ht 29

Protein kinase C (PK-C) and casein kinase II (CK-II) activities were studied in two human colon carcinoma cell lines (HT-29 and CaCO-2) undergoing differentiation in vitro resulting, in small-intestine-like cells. CaCo-2 cells, when grown under standard conditions, appear to undergo spontaneous differentiation. In these cells PK-C and CK-II activities were determined on day 5, 10 and 15. No significant differences in activities were seen either in PK-C or CK-II activity. HT-29 cells, when grown in glucose-free medium can be stimulated to undergo differentiation which is completed within 20 days. PK-C and CK-II activities were determined after 5, 10, 15, 20 and 25 days, respectively. PK-C activity rose from 7.9±3.5 pmole32P/mg protein/min at day 5 to 37.5±14.8 pmole32P/mg protein/min at day 20. After 25 days the activity was reduced to 20.0±7.8 pmole32P/mg protein/min. CK-II activity did not change significantly during day 5 to 20, but on day 25 there was a significant decrease in CK-II activity from 94.9±6.4 pmole32P/mg protein/min (day 20) to 62.6±3.9 pmole32P/mg protein/min (day 25) p=0.003. The results in this study indicate a role for PK-C and CK-II in cell growth and differentiation.

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