Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft

2003 ◽  
Vol 107 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Yongdoo Choi ◽  
Sang Yoon Kim ◽  
Sun Hee Kim ◽  
Jehoon Yang ◽  
Kyeongsoon Park ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Retinoic Acid ◽  
Tumor Growth ◽  
Head And Neck ◽  
Neck Cancer ◽  
Human Head ◽  
Biodegradable Microspheres ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Inhibition Of Tumor Growth

scholarly journals Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Chemotherapy ◽  
2010 ◽  
Vol 56 (3) ◽  
pp. 223-233 ◽  
Author(s):  
Sreenivasulu Chintala ◽  
Károly Tóth ◽  
Ming-Biao Yin ◽  
Arup Bhattacharya ◽  
Sylvia B. Smith ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Human Head ◽  
Cystine Transporter

scholarly journals Induction of sestrin 2 is associated with fisetin-mediated apoptosis in human head and neck cancer cell lines

2019 ◽  
Vol 64 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Dong-Hoon Won ◽  
Shin Hye Chung ◽  
Ji-Ae Shin ◽  
Kyoung-Ok Hong ◽  
In-Hyoung Yang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Human Head ◽  
Cancer Cell Lines

scholarly journals Glutathione Peroxidases in Human Head and Neck Cancer

1995 ◽  
Vol 115 (2) ◽  
pp. 331-333 ◽  
Author(s):  
T. P. J. Mulder ◽  
J. J. Manni ◽  
H. M. J. Roelofs ◽  
W. H. M. Peters ◽  
A. Wiersma
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Human Head ◽  
Glutathione Peroxidases

scholarly journals β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

2012 ◽  
Vol 122 (4) ◽  
pp. 1529-1540 ◽  
Author(s):  
Iris Eke ◽  
Yvonne Deuse ◽  
Stephanie Hehlgans ◽  
Kristin Gurtner ◽  
Mechthild Krause ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Human Head ◽  
Β1 Integrin ◽  
Cancer Resistance

scholarly journals Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Andrean L. Simons ◽  
Arlene D. Parsons ◽  
Katherine A. Foster ◽  
Kevin P. Orcutt ◽  
Melissa A. Fath ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Reductase Activity ◽  
Thioredoxin Reductase ◽  
Buthionine Sulfoximine ◽  
Human Head ◽  
Akt Inhibitor ◽  
Simultaneous Treatment

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSSG) in FaDu, Cal-27, and SCC-25 HNSCCs as well as causing significant clonogenic cell killing in FaDu and Cal-27, which was suppressed by simultaneous treatment with N-acetylcysteine (NAC). An inhibitor of GSH synthesis, buthionine sulfoximine (BSO), sensitized Cal-27 and SCC-25 cells to PER-induced clonogenic killing as well as decreased total GSH and increased %GSSG. Additionally, inhibition of thioredoxin reductase activity (TrxRed) with auranofin (AUR) was able to induce PER sensitization in SCC-25 cells that were initially refractory to PER. These results support the conclusion that PER induces oxidative stress and clonogenic killing in HNSCC cells that is enhanced with inhibitors of GSH and Trx metabolism.

Sign in / Sign up

Export Citation Format

Share Document