scholarly journals Negative regulatory role of PI3-Kinase in TNF-induced tumor necrosis

2003 ◽  
Vol 107 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Susanne Matschurat ◽  
Sabine Blum ◽  
Rita Mitnacht-Kraus ◽  
Henry B.P.M. Dijkman ◽  
Levent Kanal ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Pi3 Kinase ◽  
Regulatory Role ◽  
Negative Regulatory Role

scholarly journals Corrigendum: Physiological and Proteomic Analysis of the Rice Mutant cpm2 Suggests a Negative Regulatory Role of Jasmonic Acid in Drought Tolerance

2018 ◽  
Vol 9 ◽  
Author(s):  
Rohit Dhakarey ◽  
Manish L. Raorane ◽  
Achim Treumann ◽  
Preshobha K. Peethambaran ◽  
Rachel R. Schendel ◽  
...  
Keyword(s):  
Drought Tolerance ◽  
Jasmonic Acid ◽  
Proteomic Analysis ◽  
Regulatory Role ◽  
Rice Mutant ◽  
Negative Regulatory Role

scholarly journals Down-regulation of Fcα receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA

1998 ◽  
Vol 53 (5) ◽  
pp. 1321-1335 ◽  
Author(s):  
Béatrice Grossetête ◽  
Pierre Launay ◽  
Agnès Lehuen ◽  
Paul Jungers ◽  
Jean-François Bach ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Blood Cells ◽  
Regulatory Role ◽  
Down Regulation ◽  
Serum Iga ◽  
Negative Regulatory Role

scholarly journals Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation

2001 ◽  
Vol 193 (4) ◽  
pp. 471-482 ◽  
Author(s):  
Asuka Suzuki ◽  
Toshikatsu Hanada ◽  
Keiichi Mitsuyama ◽  
Takafumi Yoshida ◽  
Shintaro Kamizono ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Intestinal Inflammation ◽  
Physiological Role ◽  
Janus Kinase ◽  
Regulatory Role ◽  
Cytokine Signaling ◽  
Jak Inhibitors ◽  
Negative Regulatory Role ◽  
Severe Colitis

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription (STAT) transcription factors. We recently identified two intrinsic Janus kinase (JAK) inhibitors, JAK binding protein (JAB; also referred to as suppressor of cytokine signaling [SOCS1]/STAT-induced STAT inhibitor [SSI1]) and cytokine-inducible SH2 protein (CIS)3 (or SOCS3/SSI3), which play an essential role in the negative regulation of cytokine signaling. We have investigated the role of STATs and these JAK inhibitors in intestinal inflammation. Among STAT family members, STAT3 was most strongly tyrosine phosphorylated in human ulcerative colitis and Crohn's disease patients as well as in dextran sulfate sodium (DSS)-induced colitis in mice. Development of colitis as well as STAT3 activation was significantly reduced in IL-6–deficient mice treated with DSS, suggesting that STAT3 plays an important role in the perpetuation of colitis. CIS3, but not JAB, was highly expressed in the colon of DSS-treated mice as well as several T cell–dependent colitis models. To define the physiological role of CIS3 induction in colitis, we developed a JAB mutant (F59D-JAB) that overcame the inhibitory effect of both JAB and CIS3 and created transgenic mice. DSS induced stronger STAT3 activation and more severe colitis in F59D-JAB transgenic mice than in their wild-type littermates. These data suggest that hyperactivation of STAT3 results in severe colitis and that CIS3 plays a negative regulatory role in intestinal inflammation by downregulating STAT3 activity.

Negative regulatory role of Annexin-A1 in 14-3-3η-mediated glucocorticoid receptor transcriptional activation

2006 ◽  
Vol 339 (4) ◽  
pp. 1208-1211 ◽  
Author(s):  
Ho Joong Sung ◽  
Yong Suk Ryang ◽  
Yoon Suk Kim ◽  
Sung-Wuk Jang ◽  
Doe Sun Na ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Transcriptional Activation ◽  
Regulatory Role ◽  
Annexin A1 ◽  
Negative Regulatory Role

scholarly journals Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Immunity ◽  
1995 ◽  
Vol 3 (5) ◽  
pp. 541-547 ◽  
Author(s):  
Elizabeth A. Tivol ◽  
Frank Borriello ◽  
A.Nicola Schweitzer ◽  
William P. Lynch ◽  
Jeffrey A. Bluestone ◽  
...  
Keyword(s):  
Regulatory Role ◽  
Tissue Destruction ◽  
Negative Regulatory Role
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