scholarly journals Natural killer cell cytolytic activity is necessary forin vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan

2003 ◽  
Vol 106 (4) ◽  
pp. 528-533 ◽  
Author(s):  
D. Lynne Smith ◽  
Jie Cai ◽  
SuTao Zhu ◽  
Wen Wei ◽  
Jon Fukumoto ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Antitumor Activity ◽  
Natural Killer ◽  
Killer Cell ◽  
Cytolytic Activity

β-Endorphin and natural killer cell cytolytic activity during prolonged exercise. Is there a connection?

1998 ◽  
Vol 275 (6) ◽  
pp. R1725-R1734 ◽  
Author(s):  
G. A. Gannon ◽  
S. G. Rhind ◽  
M. Suzui ◽  
J. Zamecnik ◽  
B. H. Sabiston ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Nk Cell ◽  
Block Design ◽  
Killer Cell ◽  
Cytolytic Activity ◽  
Opioid Antagonist ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Cell Counts

This study was designed to test whether a single 50-mg dose of the opioid antagonist naltrexone hydrochloride, ingested 60 min before 2 h of moderate-intensity exercise (i.e., 65% peak O2consumption), influenced the exercise-induced augmentation of peripheral blood natural killer cell cytolytic activity (NKCA). Ten healthy male subjects were tested on four occasions separated by intervals of at least 14 days. A rested-state control trial was followed by three double-blind exercise trials [placebo (P), naltrexone (N), and indomethacin] arranged according to a random block design. The indomethacin exercise trial is discussed elsewhere (S. G. Rhind, G. A. Gannon, P. N. Shek, and R. J. Shepherd. Med. Sci. Sports Exerc. 30: S20, 1998). For both the P and N trials, plasma levels of β-endorphin were increased ( P < 0.05) at 90 and 120 min of exercise but returned to resting (preexercise) levels 2 h postexercise. CD3−CD16+CD56+NK cell counts and NKCA were significantly ( P < 0.05) elevated at each 30-min interval of exercise compared with correspondingly timed resting control values. However, there were no differences in NK cell counts or NKCA between P and N trials at any time point during the two trials. Changes in NKCA reflected mainly changes in NK cell count ( r = 0.72; P < 0.001). The results do not support the hypothesis that the enhancement of NKCA during prolonged submaximal aerobic exercise is mediated by β-endorphin.

scholarly journals Histone deacetylase inhibitors suppress natural killer cell cytolytic activity

FEBS Letters ◽  
2007 ◽  
Vol 581 (7) ◽  
pp. 1317-1322 ◽  
Author(s):  
Henry Ogbomo ◽  
Martin Michaelis ◽  
Jörg Kreuter ◽  
Hans Wilhelm Doerr ◽  
Jindrich Cinatl
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Killer Cell ◽  
Cytolytic Activity

scholarly journals Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor

2013 ◽  
Vol 110 (30) ◽  
pp. 12391-12396 ◽  
Author(s):  
J. H. Shin ◽  
L. Zhang ◽  
O. Murillo-Sauca ◽  
J. Kim ◽  
H. E. K. Kohrt ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Antitumor Activity ◽  
Aryl Hydrocarbon Receptor ◽  
Natural Killer ◽  
Killer Cell ◽  
Aryl Hydrocarbon

Demethylating treatment suppresses natural killer cell cytolytic activity

2009 ◽  
Vol 46 (10) ◽  
pp. 2064-2070 ◽  
Author(s):  
Xiao-ning Gao ◽  
Ji Lin ◽  
Li-li Wang ◽  
Li Yu
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cytolytic Activity

Interleukin-4-induced natural killer cell antitumor activity in metastatic melanoma patients

2020 ◽  
Vol 31 (3) ◽  
pp. 104-112
Author(s):  
Ana M. Vuletić ◽  
Gordana M. Konjević ◽  
Annette K. Larsen ◽  
Nada L. Babović ◽  
Vladimir B. Jurišić ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Antitumor Activity ◽  
Metastatic Melanoma ◽  
Natural Killer ◽  
Killer Cell ◽  
Interleukin 4 ◽  
Melanoma Patients
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