scholarly journals Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia

2003 ◽  
Vol 106 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Jochen Greiner ◽  
Mark Ringhoffer ◽  
Masanori Taniguchi ◽  
Thomas Hauser ◽  
Anita Schmitt ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Immune Responses ◽  
Myeloid Leukemia ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Characterization of Humoral Immune Responses to Chlamydial HSP60, CPAF, and CT795 in Inflammatory and Severe Trachoma

2010 ◽  
Vol 51 (10) ◽  
pp. 5128 ◽  
Author(s):  
Troy Skwor ◽  
Ram Prasad Kandel ◽  
Sunniya Basravi ◽  
Aslam Khan ◽  
Bassant Sharma ◽  
...  
Keyword(s):  
Immune Responses ◽  
Humoral Immune ◽  
Humoral Immune Responses

Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies

Blood ◽  
2002 ◽  
Vol 99 (9) ◽  
pp. 3272-3279 ◽  
Author(s):  
Olga A. Elisseeva ◽  
Yoshihiro Oka ◽  
Akihiro Tsuboi ◽  
Kiyoyuki Ogata ◽  
Fei Wu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Myeloid Leukemia ◽  
Wilms Tumor ◽  
Immunoglobulin Isotype ◽  
Hematopoietic Malignancies ◽  
Humoral Immune ◽  
Cell Responses ◽  
Humoral Immune Responses ◽  
Wt1 Protein ◽  
Tumor Gene

Abstract Wilms tumor gene WT1 is expressed at high levels in hematopoietic malignancies, such as leukemias and myelodysplastic syndromes (MDS), and in various kinds of solid tumors, including lung cancer, and it exerts an oncogenic function in these malignancies. IgM and IgG WT1 antibodies were measured by means of dot blot assay in 73 patients with hematopoietic malignancies (16 acute myeloid leukemia [AML], 11 acute lymphoid leukemia [ALL], 13 chronic myeloid leukemia [CML], and 33 MDS) and 43 healthy volunteers. Immunoglobulin IgM, IgG, and IgM+IgG WT1 antibodies were detected in 40 (54.8%), 40 (54.8%), and 24 (32.8%), respectively, of the 73 patients with hematopoietic malignancies, whereas 7 (16.2%), 2 (4.7%), and none of the 43 healthy volunteers had IgM, IgG, or IgM+IgG WT1 antibodies, respectively. Furthermore, immunoglobulin isotype class switching of WT1 antibodies from IgM to IgG occurred in conjunction with disease progression from refractory anemia (RA) to RA with excess of blasts (RAEB), and further to RAEB in transformation (RAEB-t) in MDS patients. These results showed that humoral immune responses against the WT1 protein could be elicited in patients with WT1-expressing hematopoietic malignancies, and they suggested that the helper T-cell responses needed to induce humoral immune responses and immunoglobulin isotype class switching from IgM to IgG were also generated in these patients. Our findings may provide new insight into the rationale for elicitation of cytotoxic T-cell responses against the WT1 protein in cancer immunotherapy using the WT1 vaccine.

scholarly journals Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers

2008 ◽  
Vol 123 (11) ◽  
pp. 2626-2631 ◽  
Author(s):  
Miriam Reuschenbach ◽  
Tim Waterboer ◽  
Keng-Ling Wallin ◽  
Jens Einenkel ◽  
Joakim Dillner ◽  
...  
Keyword(s):  
Immune Responses ◽  
Hpv16 E6 ◽  
Humoral Immune ◽  
Humoral Immune Responses

Characterization of cellular and humoral immune responses to alkaline phosphatase from fertile hydatid cysts in the human peripheral blood

2018 ◽  
Vol 234 (3) ◽  
pp. 2765-2777 ◽  
Author(s):  
Ali Vatankhah ◽  
Seyed Mohamad Reza Ghaffari ◽  
Reza G. Vatankhah ◽  
Violetta Piurkó ◽  
József Tímár ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Immune Responses ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Hydatid Cysts ◽  
Humoral Immune ◽  
Humoral Immune Responses
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