Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma

2003 ◽  
Vol 103 (6) ◽  
pp. 768-774 ◽  
Author(s):  
Arnolda G. de Nooij-van Dalen ◽  
Guus A.M.S. van Dongen ◽  
Serge J. Smeets ◽  
Eline J.C. Nieuwenhuis ◽  
Marijke Stigter-van Walsum ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Molecular Markers in Head and Neck Squamous Cell Carcinoma: Their Biological Function and Prognostic Significance

2001 ◽  
Vol 110 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Benjamin D. Smith ◽  
Bruce G. Haffty ◽  
Clarence T. Sasaki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Function ◽  
Prognostic Significance ◽  
Growth Factor Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Increased Risk

Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.

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