scholarly journals Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating ?v?5 vitronectin receptor cell surface expression

2002 ◽  
Vol 102 (6) ◽  
pp. 562-571 ◽  
Author(s):  
Immacolata Silvestri ◽  
Immacolata Longanesi Cattani ◽  
Paola Franco ◽  
Giuseppe Pirozzi ◽  
Gerardo Botti ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Migration And Invasion ◽  
Vitronectin Receptor ◽  
Cell Migration And Invasion

scholarly journals MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Marilyne Kpetemey ◽  
Subhamoy Dasgupta ◽  
Smrithi Rajendiran ◽  
Susobhan Das ◽  
Lee D. Gibbs ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Surface ◽  
Tumor Cell ◽  
Surface Expression ◽  
Annexin A2 ◽  
Cell Surface Expression ◽  
Tumor Cell Migration

scholarly journals Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32675 ◽  
Author(s):  
Gina M. Whitaker ◽  
Francis C. Lynn ◽  
Christopher H. S. McIntosh ◽  
Eric A. Accili
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression

scholarly journals Individual cells traffic the Vasopressin 2 Receptor to their cell surface with different success

2021 ◽  
Author(s):  
Eline J Koers ◽  
Bradley A Morgan ◽  
Iain B Styles ◽  
Dmitry J Veprintsev
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
G Protein Coupled Receptors ◽  
Cell Surface Expression ◽  
Subcellular Localisation ◽  
Equal Distribution ◽  
Mutant Receptors ◽  
G Protein Coupled ◽  
Correct Expression

G protein coupled receptors (GPCRs) translate the actions of hormones and neurotransmitters into intracellular signalling events. Mutations in GPCRs can prevent their correct expression and trafficking to the cell surface and cause disease. Single cell subcellular localisation measurements reveal that while some cells appear to traffic the majority of the vasopressin 2 receptor (V2R) molecules to the cell surface, others retain a greater number of receptors in the ER or have approximately equal distribution. Mutations in the V2R affect the proportion of cells able to send this GPCR to their cell surface but surprisingly they do not prevent all cells from correctly trafficking the mutant receptors. These findings reveal the potential for rescue of mutant receptor cell surface expression by pharmacological manipulation of the GPCR folding and trafficking machinery.

CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression

2008 ◽  
Vol 369 (2) ◽  
pp. 603-608 ◽  
Author(s):  
Kay Maeda ◽  
Mitsuya Haraguchi ◽  
Atsuo Kuramasu ◽  
Takeya Sato ◽  
Kyohei Ariake ◽  
...  
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Histamine H3

scholarly journals Microbial Disease Spectrum Linked to a Novel IL-12Rβ1 N-Terminal Signal Peptide Stop-Gain Homozygous Mutation with Paradoxical Receptor Cell-Surface Expression

2017 ◽  
Vol 8 ◽  
Author(s):  
Thais Louvain de Souza ◽  
Regina C. de Souza Campos Fernandes ◽  
Juliana Azevedo da Silva ◽  
Vladimir Gomes Alves Júnior ◽  
Adelia Gomes Coelho ◽  
...  
Keyword(s):  
Cell Surface ◽  
Signal Peptide ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Homozygous Mutation ◽  
Disease Spectrum ◽  
Microbial Disease

scholarly journals P2X7 Receptor Cell Surface Expression and Cytolytic Pore Formation Are Regulated by a Distal C-terminal Region

2002 ◽  
Vol 278 (10) ◽  
pp. 8853-8860 ◽  
Author(s):  
Megan L. Smart ◽  
Ben Gu ◽  
Rekha G. Panchal ◽  
James Wiley ◽  
Brett Cromer ◽  
...  
Keyword(s):  
Cell Surface ◽  
P2x7 Receptor ◽  
Pore Formation ◽  
Receptor Cell ◽  
Surface Expression ◽  
Terminal Region ◽  
Cell Surface Expression

scholarly journals Hypoxia-inducible Factor Regulates αvβ3 Integrin Cell Surface Expression

2005 ◽  
Vol 16 (4) ◽  
pp. 1901-1912 ◽  
Author(s):  
Karen D. Cowden Dahl ◽  
Sarah E. Robertson ◽  
Valerie M. Weaver ◽  
M. Celeste Simon
Keyword(s):  
Cell Surface ◽  
Cell Fate ◽  
Hypoxia Inducible Factor ◽  
Focal Adhesions ◽  
Surface Expression ◽  
Melanoma Cells ◽  
Cell Surface Expression ◽  
Migration And Invasion ◽  
Αvβ3 Integrin ◽  
And Migration

Hypoxia-inducible factor (HIF)-deficient placentas exhibit a number of defects, including changes in cell fate adoption, lack of fetal angiogenesis, hypocellularity, and poor invasion into maternal tissue. HIF is a heterodimeric transcription factor consisting of α and β aryl hydrocarbon receptor nuclear translocator or ARNT) subunits. We used undifferentiated trophoblast stem (TS) cells to characterize HIF-dependent adhesion, migration, and invasion. Arnt-/- and Hifα-/- TS cells exhibit reduced adhesion and migration toward vitronectin compared with wild-type cells. Furthermore, this defect is associated with decreased cell surface expression of integrin αvβ3 and significantly decreased expression of this integrin in focal adhesions. Because of the importance of adhesion and migration in tumor progression (in addition to placental development), we examined the affect of culturing B16F0 melanoma cells in 1.5% oxygen (O2). Culturing B16F0 melanoma cells at 1.5% O2 resulted in increased αvβ3 integrin surface expression and increased adhesion to and migration toward vitronectin. Together, these data suggest that HIF and O2 tension influence placental invasion and tumor migration by increasing cell surface expression of αvβ3 integrin.

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