Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer

2002 ◽  
Vol 102 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Ewa Rajpert-De Meyts ◽  
Henrik Leffers ◽  
Gedske Daugaard ◽  
Charlotte B. Andersen ◽  
Peter M. Petersen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Receptor Gene ◽  
Cell Cancer ◽  
Androgen Receptor Gene ◽  
Germ Cell Cancer ◽  
Repeat Length ◽  
Cag Repeat ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Cancer

scholarly journals Polymorphic variation in the androgen receptor gene: Association with risk of testicular germ cell cancer and metastatic disease

2011 ◽  
Vol 47 (3) ◽  
pp. 413-419 ◽  
Author(s):  
Åke Västermark ◽  
Yvonne Lundberg Giwercman ◽  
Oskar Hagströmer ◽  
Ewa Rajpert De-Meyts ◽  
Jakob Eberhard ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Metastatic Disease ◽  
Receptor Gene ◽  
Cell Cancer ◽  
Androgen Receptor Gene ◽  
Germ Cell Cancer ◽  
Polymorphic Variation ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Cancer

scholarly journals Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment

2017 ◽  
Vol 19 (5) ◽  
pp. 538 ◽  
Author(s):  
Karolina Bogefors ◽  
YvonneLundberg Giwercman ◽  
Jakob Eberhard ◽  
Olof Stahl ◽  
Eva Cavallin-Stahl ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Cancer Treatment ◽  
Receptor Gene ◽  
Cell Cancer ◽  
Androgen Receptor Gene ◽  
Germ Cell Cancer ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Cancer

437: Predictability of Androgen Deficiency in Testicular Germ Cell Cancer Patients by Residual Testicular Volume

2005 ◽  
Vol 173 (4S) ◽  
pp. 119-119 ◽  
Author(s):  
Gerald Puehse ◽  
Armin Secker ◽  
Sebastian Kemper ◽  
Lothar Hertle ◽  
Sabine Kliesch
Keyword(s):  
Germ Cell ◽  
Cancer Patients ◽  
Cell Cancer ◽  
Germ Cell Cancer ◽  
Testicular Volume ◽  
Androgen Deficiency ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Cancer

Acid isoelectric variants of hCG in testicular germ cell cancer

1984 ◽  
Vol 104 (4_Supplb) ◽  
pp. S122
Author(s):  
K. MANN ◽  
G. SPÖTTL ◽  
B. PUTZ ◽  
H. J. KARL
Keyword(s):  
Germ Cell ◽  
Cell Cancer ◽  
Germ Cell Cancer ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Cancer

Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniel A. Landero-Huerta ◽  
Rosa M. Vigueras-Villaseñor ◽  
Lucía Taja-Chayeb ◽  
Fabiola García-Andrade ◽  
Elena Aréchaga-Ocampo ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Receptor Gene ◽  
Germ Cell Tumors ◽  
Androgen Receptor Gene ◽  
Testicular Descent ◽  
Healthy Individuals ◽  
Testicular Germ Cell ◽  
Molecular Alteration ◽  
Mexican Patients

Abstract Objectives Cryptorchidism is the most common genitourinary birth defect in live newborn males and is considered as an important risk factor for testicular germ cell tumors and infertility. The Androgen Receptor gene is important in this pathology due to its participation, mainly, in the inguinoscrotal phase of testicular descent. We determine the length of the CAG tract in the Androgen Receptor (AR) gene in Mexican patients with nonsyndromic cryptorchidism. Methods One hundred and 15 males were included; of these, 62 had nonsyndromic cryptorchidism and 53 were healthy volunteers. DNA was extracted from a peripheral blood samples, subsequently, the CAG tract in exon 1 of AR gene was amplified by PCR and sequenced. Results Mexican patients with nonsyndromic cryptorchidism presented 25.03 ± 2.58 repeats of CAG tract in the AR gene compared to 22.72 ± 3.17 repeats of CAG tract in Mexican healthy individuals (p≤0.0001; t value of 4.3). Furthermore, the deletion of codon 57 that corresponds to the deletion of a leucine residue at position 57 (Del L57) in the AR gene was found for the first time in a nonsyndromic cryptorchidism patient. This molecular alteration has been related previously to testicular germ cell tumor (TGCT). Conclusions The CAG tract in the AR gene is longer in patients with nonsyndromic cryptorchidism than in healthy individuals, supporting the association between this polymorphism of the AR gene and nonsyndromic cryptorchidism in the Mexican population.

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