scholarly journals Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance

2002 ◽  
Vol 99 (6) ◽  
pp. 809-816 ◽  
Author(s):  
Toshiro Kageshita ◽  
Yumiko Kashio ◽  
Akira Yamauchi ◽  
Masako Seki ◽  
Mohammad Jainul Abedin ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Cell Aggregation ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Melanoma Cell Lines

Role of the interferon-stimulated response element in HLA-B downregulation in human melanoma cell lines

1999 ◽  
Vol 49 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Marieke Griffioen ◽  
Ilse J. M. Ouwerkerk ◽  
Veronique Harten ◽  
Sam J. P. Gobin ◽  
Peter J. van den Elsen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Response Element ◽  
Melanoma Cell Lines

scholarly journals Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors

2020 ◽  
Vol 21 (14) ◽  
pp. 5025
Author(s):  
Héloïse M. Leclair ◽  
Nina Tardif ◽  
Anaïs Paris ◽  
Marie-Dominique Galibert ◽  
Sébastien Corre
Keyword(s):  
Cell Lines ◽  
Melanoma Cell ◽  
Therapeutic Potential ◽  
Progression Free Survival ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Melanoma Cell Lines

BRAF and MEK inhibitors (BRAFi and MEKi) are the standard of care for the treatment of metastatic melanoma in patients with BRAFV600E mutations, greatly improving progression-free survival. However, the acquisition of resistance to BRAFi and MEKi remains a difficult clinical challenge, with limited therapeutic options available for these patients. Here, we investigated the therapeutic potential of natural flavonoids as specific AhR (Aryl hydrocarbon Receptor) transcription factor antagonists in combination with BRAFi. Experimental Design: Experiments were performed in vitro and in vivo with various human melanoma cell lines (mutated for BRAFV600E) sensitive or resistant to BRAFi. We evaluated the role of various flavonoids on cell sensitivity to BRAFi and their ability to counteract resistance and the invasive phenotype of melanoma. Results: Flavonoids were highly effective in potentiating BRAFi therapy in human melanoma cell lines by increasing sensitivity and delaying the pool of resistant cells that arise during treatment. As AhR antagonists, flavonoids counteracted a gene expression program associated with the acquisition of resistance and phenotype switching that leads to an invasive and EMT-like phenotype. Conclusions: The use of natural flavonoids opens new therapeutic opportunities for the treatment of patients with BRAF-resistant disease.

Role of MDR1 gene and P-glycoprotein expression in chemoresistance of human melanoma cell lines

1994 ◽  
Vol 5 ◽  
pp. 9
Author(s):  
W Berger ◽  
L Elbling ◽  
M Menai-Pour ◽  
M Vetterlein ◽  
R Pirker ◽  
...  
Keyword(s):  
Cell Lines ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Mdr1 Gene ◽  
P Glycoprotein ◽  
Melanoma Cell Lines

STUDIES ON THE ROLE OF TISSUE TRANSGLUTAMINASE IN HUMAN MELANOMA CELL LINES

1996 ◽  
Vol 24 (4) ◽  
pp. 510S-510S
Author(s):  
C. I. Scholfield ◽  
P. A. Smethurst ◽  
B. L. Nicholas ◽  
R. C. Rees ◽  
M. Griffin
Keyword(s):  
Cell Lines ◽  
Melanoma Cell ◽  
Tissue Transglutaminase ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Melanoma Cell Lines

In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines

1997 ◽  
Vol 33 (3) ◽  
pp. 463-470 ◽  
Author(s):  
A. Photiou ◽  
P. Shah ◽  
L.K. Leong ◽  
J. Moss ◽  
S. Retsas
Keyword(s):  
Cell Lines ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Melanoma Cell Lines

Antitumoral action of the neurokinin-1 receptor antagonist L-733 060 on human melanoma cell lines

2004 ◽  
Vol 14 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Miguel Mu??oz ◽  
Ana P??rez ◽  
Marisa Rosso ◽  
Carmen Zamarriego ◽  
Rosario Rosso
Keyword(s):  
Receptor Antagonist ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Antitumoral Action ◽  
Melanoma Cell Lines
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