Sophoranone, extracted from a traditional Chinese medicineShan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores

2002 ◽  
Vol 99 (6) ◽  
pp. 879-890 ◽  
Author(s):  
Sachiko Kajimoto ◽  
Noriko Takanashi ◽  
Tetsuya Kajimoto ◽  
Man Xu ◽  
Judong Cao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Permeability Transition ◽  
Reactive Oxygen ◽  
Permeability Transition ◽  
Human Leukemia ◽  
U937 Cells ◽  
Oxygen Species ◽  
Mitochondrial Permeability ◽  
Permeability Transition Pores

scholarly journals Physiological and Pathophysiological Roles of Mitochondrial Na+-Ca2+ Exchanger, NCLX, in Hearts

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1876
Author(s):  
Ayako Takeuchi ◽  
Satoshi Matsuoka
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Oxygen Species ◽  
Cardiac Mitochondria ◽  
Efflux System ◽  
Biophysical Properties ◽  
Mitochondrial Permeability ◽  
Cardiac Functions ◽  
Permeability Transition Pores

It has been over 10 years since SLC24A6/SLC8B1, coding the Na+/Ca2+/Li+ exchanger (NCLX), was identified as the gene responsible for mitochondrial Na+-Ca2+ exchange, a major Ca2+ efflux system in cardiac mitochondria. This molecular identification enabled us to determine structure–function relationships, as well as physiological/pathophysiological contributions, and our understandings have dramatically increased. In this review, we provide an overview of the recent achievements in relation to NCLX, focusing especially on its heart-specific characteristics, biophysical properties, and spatial distribution in cardiomyocytes, as well as in cardiac mitochondria. In addition, we discuss the roles of NCLX in cardiac functions under physiological and pathophysiological conditions—the generation of rhythmicity, the energy metabolism, the production of reactive oxygen species, and the opening of mitochondrial permeability transition pores.

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