scholarly journals Overexpression of interleukin-15in vivo enhances antitumor activity against mhc class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response

2002 ◽  
Vol 99 (4) ◽  
pp. 573-578 ◽  
Author(s):  
Toshiki Yajima ◽  
Hitoshi Nishimura ◽  
Worawidh Wajjwalku ◽  
Mamoru Harada ◽  
Hiroyuki Kuwano ◽  
...  
Keyword(s):  
T Cell ◽  
Malignant Melanoma ◽  
Antitumor Activity ◽  
Mhc Class I ◽  
Cell Response ◽  
T Cell Response ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Nk Activity

scholarly journals Modulation of CD8+ T Cell Response to Antigen by the Levels of Self MHC Class I

2001 ◽  
Vol 166 (9) ◽  
pp. 5416-5421 ◽  
Author(s):  
Fabio R. Santori ◽  
Ivica Arsov ◽  
Stanislav Vukmanović
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Class I

MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response

2011 ◽  
Vol 74 (5) ◽  
pp. 728-743 ◽  
Author(s):  
Vivekananda Shetty ◽  
Gomathinayagam Sinnathamby ◽  
Zacharie Nickens ◽  
Punit Shah ◽  
Julie Hafner ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Mhc Class I ◽  
Cell Response ◽  
Tumor Antigens ◽  
T Cell Response ◽  
Class I

scholarly journals Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.

1990 ◽  
Vol 171 (5) ◽  
pp. 1815-1820 ◽  
Author(s):  
P Aichele ◽  
H Hengartner ◽  
R M Zinkernagel ◽  
M Schulz
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Lymphocytic Choriomeningitis ◽  
Effector T Cells ◽  
T Cell Response ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Effector T Cell

Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.

scholarly journals An MHC-restricted CD8+ T-cell response is induced in cattle by foot-and-mouth disease virus (FMDV) infection and also following vaccination with inactivated FMDV

2008 ◽  
Vol 89 (3) ◽  
pp. 667-675 ◽  
Author(s):  
Efrain Guzman ◽  
Geraldine Taylor ◽  
Bryan Charleston ◽  
Michael A. Skinner ◽  
Shirley A. Ellis
Keyword(s):  
T Cell ◽  
Mhc Class I ◽  
Cell Response ◽  
Foot And Mouth Disease ◽  
T Cell Response ◽  
Class I ◽  
Structural Proteins ◽  
Infected Cattle ◽  
Cell Responses ◽  
Mouth Disease Virus

Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hooved animals that carries enormous economic consequences. CD8+ cytotoxic T lymphocytes play an important role in protection and disease outcome in viral infections but, to date, the role of the CD8+ T-cell immune response to FMDV remains unclear. This study aimed to investigate major histocompatibility complex (MHC) class I-restricted CD8+ T-cell responses to FMDV in vaccinated and in infected cattle. An in vitro assay was used to detect antigen-specific gamma interferon release by CD8+ T cells in FMDV-infected cattle of known MHC class I genotypes. A significant MHC class I-restricted CD8+ T-cell response was detected to both FMDV strain O1 BFS and a recombinant fowlpox virus expressing the structural proteins of FMDV. Antigen-specific MHC class I-restricted CD8+ T-cell responses were also detected in cattle vaccinated with inactivated FMDV. These responses were shown to be directed, at least in part, to epitopes within the structural proteins (P12A region) of the virus. By using mouse cells expressing single cattle MHC class I alleles, it was possible to identify the restriction elements in each case. Identification of these epitopes will facilitate the quantitative and qualitative analysis of FMDV-specific memory CD8+ T cells in cattle and help to ensure that potential vaccines induce a qualitatively appropriate CD8+ T-cell response.

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