Radiation effects on soluble metabolites in cultured HeLa cells examined by 1H MRS: Changes in concentration of glutathione and of lipid catabolites induced by gamma rays and proton beams

2001 ◽  
Vol 96 (S1) ◽  
pp. 27 ◽  
Author(s):  
Sveva Grande ◽  
Anna Maria Luciani ◽  
Antonella Rosi ◽  
Roberto Cherubini ◽  
Mariangela Conzato ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Hela Cells ◽  
Radiation Effects ◽  
1H Mrs ◽  
Proton Beams

BIOPHYSICAL SIMULATION TOOL PARTRAC: MODELLING PROTON BEAMS AT THERAPY-RELEVANT ENERGIES

2019 ◽  
Vol 186 (2-3) ◽  
pp. 172-175 ◽  
Author(s):  
Werner Friedland ◽  
Pavel Kundrát ◽  
Janine Becker ◽  
Markus Eidemüller
Keyword(s):  
Dna Damage ◽  
Penetration Depth ◽  
Radiation Effects ◽  
Bragg Peak ◽  
High Energy ◽  
Simulation Tool ◽  
Radiation Physics ◽  
Proton Beams ◽  
Biological Effectiveness ◽  
Penetration Depths

ABSTRACT The biophysical simulation tool PARTRAC has been primarily developed to model radiation physics, chemistry and biology on nanometre to micrometre scales. However, the tool can be applied in simulating radiation effects in an event-by-event manner over macroscopic volumes as well. Benchmark simulations are reported showing that PARTRAC does reproduce the macroscopic Bragg peaks of proton beams, although the penetration depths are underestimated by a few per cent for high-energy beams. PARTRAC also quantifies the increase in DNA damage and its complexity along the beam penetration depth. Enhanced biological effectiveness is predicted in particular within distal Bragg peak parts of therapeutic proton beams.

Radiation effects in cultured tumour cells examined by 1H MRS: mobile lipids modulation and proliferative arrest

2006 ◽  
Vol 122 (1-4) ◽  
pp. 202-204 ◽  
Author(s):  
S. Grande ◽  
C. Giovannini ◽  
A. M. Luciani ◽  
A. Palma ◽  
A. Rosi ◽  
...  
Keyword(s):  
Radiation Effects ◽  
Tumour Cells ◽  
1H Mrs

scholarly journals Standard Practice for Dosimetry of Proton Beams for use in Radiation Effects Testing of Electronics

2008 ◽  
Author(s):  
Margaret A. McMahan ◽  
Ewart Blackmore ◽  
Ethan W. Cascio ◽  
Carlos Castaneda ◽  
Barbara von Przewoski ◽  
...  
Keyword(s):  
Radiation Effects ◽  
Proton Beams ◽  
Standard Practice

Radiation effects of 200 MeV proton beams on Nd–Fe–B magnets

2003 ◽  
Vol 209 ◽  
pp. 362-366 ◽  
Author(s):  
Y. Ito ◽  
K. Yasuda ◽  
M. Sasase ◽  
R. Ishigami ◽  
S. Hatori ◽  
...  
Keyword(s):  
Radiation Effects ◽  
Proton Beams

scholarly journals Mutagenic Effect of Proton Beams Characterized by Phenotypic Analysis and Whole Genome Sequencing in Arabidopsis

2021 ◽  
Vol 12 ◽  
Author(s):  
Sang Woo Lee ◽  
Yu-Jeong Kwon ◽  
Inwoo Baek ◽  
Hong-Il Choi ◽  
Joon-Woo Ahn ◽  
...  
Keyword(s):  
Proton Beam ◽  
Gamma Rays ◽  
Gamma Ray ◽  
Mutagenic Effect ◽  
Mutation Rates ◽  
Whole Genome ◽  
Structural Variations ◽  
Proton Beam Irradiation ◽  
Proton Beams ◽  
Gamma Ray Irradiation

Protons may have contributed to the evolution of plants as a major component of cosmic-rays and also have been used for mutagenesis in plants. Although the mutagenic effect of protons has been well-characterized in animals, no comprehensive phenotypic and genomic analyses has been reported in plants. Here, we investigated the phenotypes and whole genome sequences of Arabidopsis M2 lines derived by irradiation with proton beams and gamma-rays, to determine unique characteristics of proton beams in mutagenesis. We found that mutation frequency was dependent on the irradiation doses of both proton beams and gamma-rays. On the basis of the relationship between survival and mutation rates, we hypothesized that there may be a mutation rate threshold for survived individuals after irradiation. There were no significant differences between the total mutation rates in groups derived using proton beam or gamma-ray irradiation at doses that had similar impacts on survival rate. However, proton beam irradiation resulted in a broader mutant phenotype spectrum than gamma-ray irradiation, and proton beams generated more DNA structural variations (SVs) than gamma-rays. The most frequent SV was inversion. Most of the inversion junctions contained sequences with microhomology and were associated with the deletion of only a few nucleotides, which implies that preferential use of microhomology in non-homologous end joining was likely to be responsible for the SVs. These results show that protons, as particles with low linear energy transfer (LET), have unique characteristics in mutagenesis that partially overlap with those of low-LET gamma-rays and high-LET heavy ions in different respects.

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