Spontaneous hybridization of macrophages and Meth A sarcoma cells

2002 ◽  
Vol 98 (4) ◽  
pp. 573-581 ◽  
Author(s):  
Lill-Tove R. Busund ◽  
Mette K. Killie ◽  
Kristian Bartnes ◽  
Randi Olsen ◽  
Rolf Seljelid
Keyword(s):  
Sarcoma Cells ◽  
Meth A Sarcoma

scholarly journals Suppression of intracellular Cu-Zn SOD results in enhanced motility and metastasis of Meth A sarcoma cells

1997 ◽  
Vol 73 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Maki Tanaka ◽  
Katsuhisa Kogawa ◽  
Yoshiki Nishihori ◽  
Kageaki Kuribayashi ◽  
Kiminori Nakamura ◽  
...  
Keyword(s):  
Sarcoma Cells ◽  
Meth A Sarcoma

Spontaneously formed tumorigenic hybrids of Meth A sarcoma cells and macrophagesin vivo

2003 ◽  
Vol 106 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Lill-Tove R. Busund ◽  
Mette K. Killie ◽  
Kristian Bartnes ◽  
Rolf Seljelid
Keyword(s):  
Sarcoma Cells ◽  
Meth A Sarcoma

scholarly journals Effect of heat and glutaraldehyde upon the immunogenicity of Meth A sarcoma cells

1979 ◽  
Vol 40 (4) ◽  
pp. 663-665 ◽  
Author(s):  
M R Price ◽  
R G Dennick ◽  
L W Law
Keyword(s):  
Sarcoma Cells ◽  
Meth A Sarcoma

On the Role of Transferrin in 67Ga Uptake by Tumor Cells

1988 ◽  
Vol 27 (04) ◽  
pp. 151-153
Author(s):  
P. Thouvenot ◽  
F. Brunotte ◽  
J. Robert ◽  
L. J. Anghileri
Keyword(s):  
Specific Binding ◽  
Subcellular Fractionation ◽  
Animal Blood ◽  
Tumor Bearing ◽  
Cell Structures ◽  
The Difference ◽  
Sarcoma Cells ◽  
In Vitro Uptake

In vitro uptake of 67Ga-citrate and 59Fe-citrate by DS sarcoma cells in the presence of tumor-bearing animal blood plasma showed a dramatic inhibition of both 67Ga and 59Fe uptakes: about ii/io of 67Ga and 1/5o of the 59Fe are taken up by the cells. Subcellular fractionation appears to indicate no specific binding to cell structures, and the difference of binding seems to be related to the transferrin chelation and transmembrane transport differences

Inhibition by dihydrorifampicin of RNA polymerases I and II isolated from nuclei of Rous sarcoma cells and human tumor cells HEp-2

1979 ◽  
Vol 44 (9) ◽  
pp. 2722-2736 ◽  
Author(s):  
Jindřich Kára ◽  
Zdeněk Hostomský
Keyword(s):  
Tumor Cells ◽  
Human Tumor ◽  
Tumor Cell Line ◽  
Selective Inhibition ◽  
Rna Polymerases ◽  
Embryonic Cells ◽  
Human Tumor Cells ◽  
Ribonucleic Acids ◽  
Rous Sarcoma ◽  
Sarcoma Cells

Dihydrorifampicin, a rifampicin derivative hydrogenated at the 18-19 carbon atoms of the aliphatic ansa chain of the rifampicin molecule, inhibits the enzymatic activity of RNA polymerases I and II, isolated from the nuclei of avian tumor cells (Rous sarcoma) and from the human tumor cell line HEp-2. The RNA polymerases from these tumors have been separated and partially purified by chromatography on DEAE Sephadex A-25 and characterized by the sensitivity to α-amanitin. The [3H]UMP-labeled ribonucleic acids synthesized in the isolated nuclei of Rous sarcoma cells in the presence and absence of DHR were analyzed by sedimentation analysis in sucrose density gradients. It was found that the synthesis of rRNAs and mRNAs is very significantly inhibited by dihydrorifampicin, whereas the synthesis of tRNAs is much less inhibited at the same DHR concentration (100μg/ml). The observed cytostatic effect of DHR on the growth of human tumor cells HEp-2 and embryonic cells in culture is apparently mediated by the selective inhibition of RNA polymerases I and II in human and avian cells. The relationship between the molecular structure of DHR and its affinity to RNA polymerases of eukaryotic cells is discussed.

scholarly journals Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 93
Author(s):  
Bor-Chyuan Su ◽  
Giun-Yi Hung ◽  
Yun-Chieh Tu ◽  
Wei-Chen Yeh ◽  
Meng-Chieh Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Antimicrobial Peptide ◽  
Anticancer Activity ◽  
Synovial Sarcoma ◽  
Uncoupling Protein ◽  
Reactive Oxygen ◽  
Calcium Overload ◽  
Oxygen Species ◽  
Sarcoma Cells

Synovial sarcoma is a rare but aggressive soft-tissue sarcoma associated with translocation t(X;18). Metastasis occurs in approximately 50% of all patients, and curative outcomes are difficult to achieve in this group. Since the efficacies of current therapeutic approaches for metastatic synovial sarcoma remain limited, new therapeutic agents are urgently needed. Tilapia piscidin 4 (TP4), a marine antimicrobial peptide, is known to exhibit multiple biological functions, including anti-bacterial, wound-healing, immunomodulatory, and anticancer activities. In the present study, we assessed the anticancer activity of TP4 in human synovial sarcoma cells and determined the underlying mechanisms. We first demonstrated that TP4 can induce necrotic cell death in human synovial sarcoma AsKa-SS and SW982 cells lines. In addition, we saw that TP4 initiates reactive oxygen species (ROS) production and downregulates antioxidant proteins, such as uncoupling protein-2, superoxide dismutase (SOD)-1, and SOD-2. Moreover, TP4-induced mitochondrial hyperpolarization is followed by elevation of mitochondrial ROS. Calcium overload is also triggered by TP4, and cell death can be attenuated by a necrosis inhibitor, ROS scavenger or calcium chelator. In our experiments, TP4 displayed strong anticancer activity in human synovial sarcoma cells by disrupting oxidative status, promoting mitochondrial hyperpolarization and causing calcium overload.

Rapamycin promotes autophagy cell death of Kaposi’s sarcoma cells through P75NTR activation

2021 ◽  
Author(s):  
Simona Lupinacci ◽  
Anna Perri ◽  
Giuseppina Toteda ◽  
Donatella Vizza ◽  
Danilo Lofaro ◽  
...  
Keyword(s):  
Cell Death ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Sarcoma Cells
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