scholarly journals ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

2002 ◽  
Vol 98 (3) ◽  
pp. 463-469 ◽  
Author(s):  
Fortunato Ciardiello ◽  
Rosa Caputo ◽  
Gaetano Borriello ◽  
Donatella Del Bufalo ◽  
Annamaria Biroccio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase Inhibitor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Kinase Inhibitor ◽  
Multidrug Resistant ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.

1995 ◽  
Vol 96 (2) ◽  
pp. 1026-1034 ◽  
Author(s):  
S Scala ◽  
A Budillon ◽  
Z Zhan ◽  
Y S Cho-Chung ◽  
J Jefferson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mdr 1 ◽  
Mcf 7

scholarly journals Enhancement of Doxorubicin Cytotoxicity by Verapamil in Human Breast Cancer Cells

2019 ◽  
pp. 1-10
Author(s):  
Sameer E. Al-harthy ◽  
Mashael S. Al-Motairi ◽  
Huda M. Al-Kreathy ◽  
Fatemah O. Kamel ◽  
Mohamed M. Sayed-Ahmed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Cycle Phase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Background: Worldwide, breast cancer is a main cause of morbidity and mortality in females. Doxorubicin (DOX) is an anthracycline anticancer drug and most commonly employed in polychemotherapy protocols in the treatment of solid and hematological tumors. Unfortunately, its optimal clinical benefit is limited secondary to the rapid development of DOX resistance and therapeutic failure. Aim: Therefore, the current study has been initiated to investigate the possible mechanisms whereby the calcium channel blocker Verapamil (VER) could decrease DOX resistance and enhance the cytotoxic activity of DOX against the growth of human breast cancer cells. Methodology: To achieve the ultimate goal of this study, we have examined DOX-induced cytotoxicity, apoptosis, alteration in the function of multidrug resistance proteins and cell cycle phase distribution against MCF-7 cell line in presence and absence of Verapamil.  Results: Addition of VER enhanced the cytotoxic effect of DOX against the growth of MCF-7 cells which manifested as a significant decrease in the IC50 from 36 µg/ml for DOX alone to 13 µg/ml for DOX plus VER.  Moreover, combined treatment with VER and DOX significantly increased percentage of early apoptosis and cells arrested in G0/G1 phase when compared to DOX alone. In addition, VER significantly increased DOX cellular uptake through inhibition of the function of multidrug resistant proteins.   Conclusion: VER treatment enhanced the cytotoxic activity of DOX against the growth of MCF-7 cells secondary to increase its cellular accumulation.  The observed increase in DOX uptake by VER was parallel to increased accumulation of Rho-123 dye which my point to the contribution of inhibition of multidrug resistant proteins by VER in the enhancement of DOX cytotoxicity.

scholarly journals Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin

2015 ◽  
Vol 12 (2) ◽  
pp. 1898-1904 ◽  
Author(s):  
KWANG-YOUN KIM ◽  
SANG-HUN KIM ◽  
SUN-NYOUNG YU ◽  
SUEL-KI PARK ◽  
HYEUN-DEOK CHOI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7
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