scholarly journals Dietary intake of folic acid and colorectal cancer risk in a cohort of women

2002 ◽  
Vol 97 (6) ◽  
pp. 864-867 ◽  
Author(s):  
Paul Terry ◽  
Meera Jain ◽  
Anthony B. Miller ◽  
Geoffrey R. Howe ◽  
Thomas E. Rohan
Keyword(s):  
Colorectal Cancer ◽  
Folic Acid ◽  
Cancer Risk ◽  
Dietary Intake ◽  
Colorectal Cancer Risk

scholarly journals Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta-analysis of data from 489 000 individuals

2012 ◽  
Vol 108 (9) ◽  
pp. 1550-1556 ◽  
Author(s):  
Xiao-Jian Shen ◽  
Jun-Dong Zhou ◽  
Jia-Yi Dong ◽  
Wei-Qun Ding ◽  
Jin-Chang Wu
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Dietary Intake ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Cancer Site ◽  
Pubmed Database ◽  
Incident Cases ◽  
Reduced Risk

Preclinical studies have suggested an anti-colorectal cancer effect of n-3 fatty acids, yet epidemiological studies have reported mixed results. The goal of the present meta-analysis was to examine the association between the dietary intake of n-3 fatty acids and colorectal cancer risk by conducting a meta-analysis of prospective cohort studies. We searched the PubMed database up to February 2012 to identify eligible studies. Either a fixed- or random-effects model was used to obtain a pooled relative risk (RR) comparing the highest intake of n-3 fatty acids with the lowest. We conducted subgroup analyses according to sex, geographic region, length of follow-up, cancer site and type of n-3 fatty acids. We included seven prospective studies in the meta-analysis, comprising 489 465 participants and 4656 incident cases. The pooled RR of colorectal cancer in relation to n-3 fatty acids was 0·98 (95 % CI 0·88, 1·09). The results from subgroup analysis indicated a significant reduced risk of colorectal cancer in relation to n-3 fatty acids among men (RR 0·87, 95 % CI 0·75, 1·00; n 4). No significant association was observed in other subgroups. There was no evidence of publication bias as suggested by Begg's test (P = 0·76) and Egger's test (P = 0·66). The present meta-analysis showed insufficient evidence of a protective effect of n-3 fatty acids on colorectal cancer risk. However, a reduced risk observed in men warrants further investigation.

scholarly journals Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea

2012 ◽  
Vol 95 (2) ◽  
pp. 405-412 ◽  
Author(s):  
Jeongseon Kim ◽  
Young Ae Cho ◽  
Dong-Hyun Kim ◽  
Bong-Hwa Lee ◽  
Dae-Yong Hwang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Dietary Intake ◽  
Mthfr C677t ◽  
Colorectal Cancer Risk ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

scholarly journals Gender-specific modulation of tumorigenesis by folic acid supply in the Apc+/Min mouse during early neonatal life

2008 ◽  
Vol 99 (3) ◽  
pp. 550-558 ◽  
Author(s):  
Jill A. McKay ◽  
Elizabeth A. Williams ◽  
John C. Mathers
Keyword(s):  
Colorectal Cancer ◽  
Folic Acid ◽  
Cancer Risk ◽  
Epidemiological Studies ◽  
In Utero ◽  
Colorectal Cancer Risk ◽  
Optimal Timing ◽  
Inverse Association ◽  
Neonatal Life ◽  
Pregnancy And Lactation

Epidemiological studies suggest an inverse association between folic acid intake and colorectal cancer risk. Conversely, conventional treatment of existing tumours includes the use of folate antagonists. This suggests that the level of exposure to folate and its timing in relation to stage of tumorigenesis may be critical in determining outcomes. We hypothesised that folic acid depletion in utero and during early neonatal life may affect tumorigenesis in offspring. To investigate this hypothesis, female C57Bl6/J mice were randomised to a folic acid adequate (2 mg folic acid/kg diet) or folic acid depleted diet (0·4 mg folic acid/kg) from mating with Apc+/Min sires and throughout pregnancy and lactation. At weaning the Apc+/Min offspring were randomised to a folic acid adequate (2 mg folic acid/kg diet) or depleted (0·26 mg folic acid/kg diet) diet, creating four in utero/post-weaning dietary regimens. At 10 weeks post-weaning, mice were killed and the intestinal tumour number and size were recorded. Folic acid depletion during pregnancy and post-weaning reduced erythrocyte folate concentrations in offspring significantly. Folic acid depletion during pregnancy and lactation did not affect tumour multiplicity or size. However, female mice fed normal folic acid diets post-weaning had more, and larger, tumours when compared with depleted females and both depleted and adequate folic acid fed males. These data suggest that folate depletion post-weaning was protective against neoplasia in female Apc+/Min mice and highlights the need for further investigation of the optimal timing and dose of folic acid supplementation with regard to colorectal cancer risk.

scholarly journals Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women’s Lifestyle and Health Cohort

2020 ◽  
Vol 52 (3) ◽  
pp. 848-854 ◽  
Author(s):  
Aesun Shin ◽  
Sooyoung Cho ◽  
Sven Sandin ◽  
Marie Lof ◽  
Moon Young Oh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Intake ◽  
Colorectal Cancer Risk ◽  
Fatty Acid Intake ◽  
Omega 3 ◽  
Acid Intake

PurposeWe aimed to assess the association between the dietary intake of fish-derived omega-3 polyunsaturated fatty acids and the risk of colorectal cancer among Swedish women.Materials and MethodsA total of 48,233 women with information on dietary intake were included in the analysis. Participants were followed for incident colorectal cancer until 31 December 2012. Cox proportional hazard models were used to assess the association between baseline fatty acid intake and colorectal cancer risk. All analyses were stratified by colon and rectal cancers.ResultsDuring a median of 21.3 years of follow-up, a total of 344 colorectal cancer cases were ascertained. Although there was no overall association between omega-3 fatty acid intake and colorectal cancer risk, high intake of fish-derived docosahexaenoic acid was associated with reduced risk of rectal cancer (hazard ratios for the third and the highest quartiles were 0.59 (95% confidence interval [CI], 0.37 to 0.96) and 0.62 (95% CI, 0.39 to 0.98), respectively).ConclusionIn conclusion, we found only limited support for an association between omega-3 polyunsaturated fatty acids and colorectal cancer in a large Swedish cohort of middle-aged women.

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